DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mat1 and MNAT1

DIOPT Version :9

Sequence 1:	NP_610605.1	Gene:	Mat1 / 36130	FlyBaseID:	FBgn0024956	Length:	320	Species:	Drosophila melanogaster
Sequence 2:	NP_002422.1	Gene:	MNAT1 / 4331	HGNCID:	7181	Length:	309	Species:	Homo sapiens

Alignment Length:	312	Identity:	168/312 - (53%)
Similarity:	229/312 - (73%)	Gaps:	8/312 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDDQACPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFLKGSGACPECMVPLRRNNFRVQLFED 65
            ||||.||||||||||||||||||||||||||||||||||::|:|.||||..|||::|||||||||
Human     1 MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFED 65

  Fly    66 PMVEKEVDIRRRILRDYNKREEDFASLAEYNDYLEEIEDIVYNLCNNIDIIETNKRIEAYKRDNR 130
            |.|:|||:||:::|:.||||||||.||.||||:|||:|:||:||.||:|:..|.|::|.|:::|:
Human    66 PTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKKKMEIYQKENK 130

  Fly   131 EVIQRNKTRVGRDEYALEEMLELEKVQEEARRKELEELENEHKKKKARDKQALIEELMYSGKDAA 195
            :|||:||.::.|::..|||.||:|:.:.|.||..:::.|...:..|.::|||.::||..|....|
Human   131 DVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVA 195

  Fly   196 QIVTEFAEKAEKQREEEKQLPPPKPAN--EFSTGIKFGQTADPSLLPVPKSEEGPLFVYEPLVPF 258
            .::   |:..::..:.|.||..|||..  .||||||.||..  ||.|:.|.||. |:.|:||...
Human   196 LLL---AQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHI--SLAPIHKLEEA-LYEYQPLQIE 254

  Fly   259 SEGPAMPPTNEIVSRGYIAHIRAETPQENAGGFTSALACERALQEALQGLYY 310
            :.||.:|....:...||:.|:||.:||:.|||:||:|||.||||:|..||::
Human   255 TYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFW 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mat1	NP_610605.1	cdk7	1..313	CDD:129661	168/312 (54%)
		RING	3..47	CDD:302633	38/43 (88%)
		CDC37_N	66..175	CDD:296150	54/108 (50%)
		Seryl_tRNA_N	127..215	CDD:299883	27/87 (31%)
MNAT1	NP_002422.1	cdk7	1..309	CDD:129661	168/312 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159372
Domainoid	1	1.000	183	1.000	Domainoid score	I3444
eggNOG	1	0.900	-	-		E1_COG5220
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1821
Inparanoid	1	1.050	337	1.000	Inparanoid score	I2398
Isobase	1	0.950	-	0	Normalized mean entropy	S1402
OMA	1	1.010	-	-		QHG55364
OrthoDB	1	1.010	-	-		D1454155at2759
OrthoFinder	1	1.000	-	-		FOG0005635
OrthoInspector	1	1.000	-	-		oto88824
orthoMCL	1	0.900	-	-		OOG6_103797
Panther	1	1.100	-	-	LDO	PTHR12683
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1502
SonicParanoid	1	1.000	-	-		X5285
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750