DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12338 and DDO

DIOPT Version :9

Sequence 1:	NP_001286292.1	Gene:	CG12338 / 36128	FlyBaseID:	FBgn0033543	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_001359037.1	Gene:	DDO / 8528	HGNCID:	2727	Length:	341	Species:	Homo sapiens

Alignment Length:	327	Identity:	128/327 - (39%)
Similarity:	195/327 - (59%)	Gaps:	11/327 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VLGSGIIGLTTALELQKEFPTARVSVIADRFNEDTVSYVAAGIFRPGTSFMGP--TQKITQQWMT 67
            |:|:|::||:||:.:.|..|...|::|:|:|..||.|.||||:..|.|....|  |||   ||..
Human     8 VVGAGVVGLSTAVCISKLVPRCSVTIISDKFTPDTTSDVAAGMLIPHTYPDTPIHTQK---QWFR 69

  Fly    68 DAFNYWDELRRSKEAPLAGVCQLSGYIYSRTSPSIVRNHFIEKLLPVYRRATEEELRLCNGGWKY 132
            :.||:...:..|.||..|||..:||:...:::|:.....:.:.:|. :|:.||.||:.. ..:.:
Human    70 ETFNHLFAIANSAEAGDAGVHLVSGWQIFQSTPTEEVPFWADVVLG-FRKMTEAELKKF-PQYVF 132

  Fly   133 GSFFTTCLTESRLFLPYATKKFLENGGEVVRQHVNSFFEVPQNIDLLLNCTGMGAKELCGDQHLV 197
            |..|||...|...:||:..|:...:||..:.:.:...:|:..:.|:::||:|:|:::|.||..:.
Human   133 GQAFTTLKCECPAYLPWLEKRIKGSGGWTLTRRIEDLWELHPSFDIVVNCSGLGSRQLAGDSKIF 197

  Fly   198 PIRGQVLKVRAPWVKTAFYGDYD--TYVLPGFETVTLGGCRQFDSYNTEWCKYDSMAIRERCYDL 260
            |:|||||:|:||||: .|..|..  ||:.||...|||||.||...:|......:|..|..||..|
Human   198 PVRGQVLQVQAPWVE-HFIRDGSGLTYIYPGTSHVTLGGTRQKGDWNLSPDAENSREILSRCCAL 261

  Fly   261 LPSLRKAEIVRECVGLRPHRSVVRVEPELITNPEGRRLKVVHNYGHGGYGVTTAPGTAMYAVRLV 325
            .|||..|..:||.|||||:|..||::.||:.. :|:||.|||:||||..|::...|||:.|.|||
Human   262 EPSLHGACNIREKVGLRPYRPGVRLQTELLAR-DGQRLPVVHHYGHGSGGISVHWGTALEAARLV 325

  Fly   326 RD 327
            .:
Human   326 SE 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12338	NP_001286292.1	DAO	5..324	CDD:279590	125/322 (39%)
DDO	NP_001359037.1	DAO	30..324	CDD:334462	116/300 (39%)
DDO	NP_001359037.1	Microbody targeting signal. /evidence=ECO:0000255	339..341
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159639
Domainoid	1	1.000	205	1.000	Domainoid score	I2930
eggNOG	1	0.900	-	-		E1_COG0665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H101531
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3686
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63703
OrthoDB	1	1.010	-	-		D1363414at2759
OrthoFinder	1	1.000	-	-		FOG0001083
OrthoInspector	1	1.000	-	-		otm41767
orthoMCL	1	0.900	-	-		OOG6_100720
Panther	1	1.100	-	-	O	PTHR11530
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R881
SonicParanoid	1	1.000	-	-		X916
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800