DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG12338 and DAO

DIOPT Version :9

Sequence 1:	NP_001286292.1	Gene:	CG12338 / 36128	FlyBaseID:	FBgn0033543	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_001908.3	Gene:	DAO / 1610	HGNCID:	2671	Length:	347	Species:	Homo sapiens

Alignment Length:	359	Identity:	121/359 - (33%)
Similarity:	178/359 - (49%)	Gaps:	55/359 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHFGVLGSGIIGLTTALELQKEFPTA----RVSVIADRFNEDTVSYVAAGIFRPGTSFMGPTQKI 61
            |...|:|:|:|||:|||.:.:.:.:.    .:.|.||||...|.:.||||:::|..|  .|....
Human     1 MRVVVIGAGVIGLSTALCIHERYHSVLQPLDIKVYADRFTPLTTTDVAAGLWQPYLS--DPNNPQ 63

  Fly    62 TQQWMTDAFNYWDELRRSKEAPLAGVCQLSGYIYSRTSPSIVRNHFIEKL--------LPVYRRA 118
            ...|....|:|......|..|...|:..:|||           |.|.|.:        :..:|:.
Human    64 EADWSQQTFDYLLSHVHSPNAENLGLFLISGY-----------NLFHEAIPDPSWKDTVLGFRKL 117

  Fly   119 TEEELRLCNGGWKYGSFFTTCLTESRLFLPYATKKFLENGGEVVRQHVNSFFEVP-QNIDLLLNC 182
            |..||.:. ..:.||.|.|:.:.|.:.:|.:.|::..|.|.:..::.|.||.||. :..|:::||
Human   118 TPRELDMF-PDYGYGWFHTSLILEGKNYLQWLTERLTERGVKFFQRKVESFEEVAREGADVIVNC 181

  Fly   183 TGMGAKELCGDQHLVPIRGQVLKVRAPWVKTAFY------GDYDT-YVLPGFETVTLGGCRQ--- 237
            ||:.|..|..|..|.|.|||::||.|||:|....      |.|:: |::||.:||||||..|
Human   182 TGVWAGALQRDPLLQPGRGQIMKVDAPWMKHFILTHDPERGIYNSPYIIPGTQTVTLGGIFQLGN 246

  Fly   238 ------FDSYNTEWCKYDSMAIRERCYDLLPSLRKAEIVRECVGLRPHRSVVRVEPE-LITNPEG 295
                  ...:||.|         |.|..|.|:|:.|.|:.|..|.||.|..:|:|.| |.|.|.
Human   247 WSELNNIQDHNTIW---------EGCCRLEPTLKNARIIGERTGFRPVRPQIRLEREQLRTGPS- 301

  Fly   296 RRLKVVHNYGHGGYGVTTAPGTAMYAVRLVRDLL 329
             ..:|:|||||||||:|...|.|:.|.:|...:|
Human   302 -NTEVIHNYGHGGYGLTIHWGCALEAAKLFGRIL 334

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12338	NP_001286292.1	DAO	5..324	CDD:279590	118/348 (34%)
DAO	NP_001908.3	DAO	2..329	CDD:396016	118/351 (34%)
DAO	NP_001908.3	Microbody targeting signal	345..347
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159638
Domainoid	1	1.000	205	1.000	Domainoid score	I2930
eggNOG	1	0.900	-	-		E1_COG0665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	209	1.000	Inparanoid score	I3686
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63703
OrthoDB	1	1.010	-	-		D1363414at2759
OrthoFinder	1	1.000	-	-		FOG0001083
OrthoInspector	1	1.000	-	-		otm41767
orthoMCL	1	0.900	-	-		OOG6_100720
Panther	1	1.100	-	-	O	PTHR11530
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R881
SonicParanoid	1	1.000	-	-		X916
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.840