DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12338 and Dao

DIOPT Version :9

Sequence 1:	NP_001286292.1	Gene:	CG12338 / 36128	FlyBaseID:	FBgn0033543	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_001273325.1	Gene:	Dao / 13142	MGIID:	94859	Length:	345	Species:	Mus musculus

Alignment Length:	339	Identity:	121/339 - (35%)
Similarity:	183/339 - (53%)	Gaps:	17/339 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHFGVLGSGIIGLTTALELQKEF-PT--ARVSVIADRFNEDTVSYVAAGIFRPGTSFMGPTQKIT 62
            |...|:|:|:|||:|||.:.:.: ||  ..:.:.||||...|.|.||||:::|..|  .|:....
Mouse     1 MRVAVIGAGVIGLSTALCIHERYHPTQPLHMKIYADRFTPFTTSDVAAGLWQPYLS--DPSNPQE 63

  Fly    63 QQWMTDAFNYWDELRRSKEAPLAGVCQLSGYIYSRTSPSIVRNHFIEKLLPVYRRATEEELRLCN 127
            .:|....|:|......|..|...|:..:|||...|..   |.:.|.:..:..:|:.|..|:.|.
Mouse    64 AEWSQQTFDYLLSCLHSPNAEKMGLALISGYNLFRDE---VPDPFWKNAVLGFRKLTPSEMDLF- 124

  Fly   128 GGWKYGSFFTTCLTESRLFLPYATKKFLENGGEVVRQHVNSFFEVPQNIDLLLNCTGMGAKELCG 192
            ..:.||.|.|:.|.|.:.:||:.|::..|.|.:::.:.|.|..||.:.:|:::||||:.|..|..
Mouse   125 PDYGYGWFNTSLLLEGKSYLPWLTERLTERGVKLIHRKVESLEEVARGVDVIINCTGVWAGALQA 189

  Fly   193 DQHLVPIRGQVLKVRAPWVK------TAFYGDYDT-YVLPGFETVTLGGCRQFDSYNTEWCKYDS 250
            |..|.|.|||:::|.|||:|      ....|.|:: |::||.:||||||..|..:::......|.
Mouse   190 DASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGIFQLGNWSGLNSVRDH 254

  Fly   251 MAIRERCYDLLPSLRKAEIVRECVGLRPHRSVVRVEPELITNPEGRRLKVVHNYGHGGYGVTTAP 315
            ..|.:.|..|.|:|:.|.||.|..|.||.|..||:|.|.: :......:|:|||||||||:|...
Mouse   255 NTIWKSCCKLEPTLKNARIVGELTGFRPVRPQVRLEREWL-HFGSSSAEVIHNYGHGGYGLTIHW 318

  Fly   316 GTAMYAVRLVRDLL 329
            |.||.|..|...:|
Mouse   319 GCAMEAANLFGKIL 332

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12338	NP_001286292.1	DAO	5..324	CDD:279590	118/328 (36%)
Dao	NP_001273325.1	NADB_Rossmann	1..>24	CDD:389744	10/22 (45%)
		DAO	35..327	CDD:334462	107/298 (36%)
		Microbody targeting signal	343..345
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850009
Domainoid	1	1.000	199	1.000	Domainoid score	I3062
eggNOG	1	0.900	-	-		E1_COG0665
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3723
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63703
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001083
OrthoInspector	1	1.000	-	-		otm43819
orthoMCL	1	0.900	-	-		OOG6_100720
Panther	1	1.100	-	-	O	PTHR11530
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R881
SonicParanoid	1	1.000	-	-		X916
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.830