DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12338 and Dao

DIOPT Version :9

Sequence 1:	NP_001286292.1	Gene:	CG12338 / 36128	FlyBaseID:	FBgn0033543	Length:	335	Species:	Drosophila melanogaster
Sequence 2:	NP_446078.1	Gene:	Dao / 114027	RGDID:	621138	Length:	346	Species:	Rattus norvegicus

Alignment Length:	347	Identity:	120/347 - (34%)
Similarity:	183/347 - (52%)	Gaps:	32/347 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MHFGVLGSGIIGLTTALELQKEFPTAR---VSVIADRFNEDTVSYVAAGIFRPGTSFMGPTQKIT 62
            |...|:|:|:|||:|||.:.:.:..|:   :.:.||||...|.|.||||:::|..|  .|:....
  Rat     1 MRVAVIGAGVIGLSTALCIHERYHPAQPLHMKIYADRFTPFTTSDVAAGLWQPYLS--DPSNPQE 63

  Fly    63 QQWMTDAFNYWDELRRSKEAPLAGVCQLSGYIYSRTSPSIVRNHFIEKLLPVYRRATEEELRLCN 127
            .:|....|::......|..|...|:..:|||...|..   |.:.|.:..:..:|:.|..||.:.
  Rat    64 AEWNQQTFDHLQSCLHSPNAEKMGLALISGYNLFRDE---VPDPFWKSTVLGFRKLTPSELDMF- 124

  Fly   128 GGWKYGSFFTTCLTESRLFLPYATKKFLENGGEVVRQHVNSFFEVPQ-NIDLLLNCTGMGAKELC 191
            ..:.||.|.|:.|.|.:.:|.:.|::..|.|.:.:.:.|.||.||.: .:|:::||||:.|..|.
  Rat   125 PDYSYGWFNTSLLLEGKSYLSWLTERLTERGVKFIHRKVASFEEVVRGGVDVIINCTGVWAGALQ 189

  Fly   192 GDQHLVPIRGQVLKVRAPWVK------TAFYGDYDT-YVLPGFETVTLGGCRQFDSYNTEWCKYD 249
            .|..|.|.|||:::|.|||:|      ....|.|:: |::||.:||||||..|..:::.....:|
  Rat   190 ADASLQPGRGQIIQVEAPWIKHFILTHDPSLGIYNSPYIIPGSKTVTLGGVFQLGNWSELNSVHD 254

  Fly   250 SMAIRERCYDLLPSLRKAEIVRECVGLRPHRSVVRVEPELITNPEGRRLK-------VVHNYGHG 307
            ...|.:.|..|.|:|:.|.|:.|..|.||.|..||:|.|        ||:       |:||||||
  Rat   255 HNTIWKSCCQLEPTLKNARIMGELTGFRPVRPQVRLERE--------RLRFGSSSAEVIHNYGHG 311

  Fly   308 GYGVTTAPGTAMYAVRLVRDLL 329
            |||:|...|.||.|..|...:|
  Rat   312 GYGLTIHWGCAMEAANLFGKIL 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12338	NP_001286292.1	DAO	5..324	CDD:279590	117/336 (35%)
Dao	NP_446078.1	DAO	2..328	CDD:396016	117/339 (35%)
Dao	NP_446078.1	Microbody targeting signal	344..346
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353690
Domainoid	1	1.000	200	1.000	Domainoid score	I2945
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	205	1.000	Inparanoid score	I3651
OMA	1	1.010	-	-		QHG63703
OrthoDB	1	1.010	-	-		D1363414at2759
OrthoFinder	1	1.000	-	-		FOG0001083
OrthoInspector	1	1.000	-	-		otm45899
orthoMCL	1	0.900	-	-		OOG6_100720
Panther	1	1.100	-	-	O	PTHR11530
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X916
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.910