Protein Alignment Rab3 and RAB6C

DIOPT Version :10

• Sequence 1: NP_523687.1
• Gene: Rab3 / 36127
• FlyBaseID: FBgn0005586
• Length: 220
• Species: Drosophila melanogaster
• Sequence 2: NP_115520.2
• Gene: RAB6C / 84084
• HGNCID: 16525
• Length: 254
• Species: Homo sapiens
• Alignment Length: 231
• Identity: 77/231 - (33%)
• Similarity: 117/231 - (50%)
• Gaps: 34/231 - (14%)

  Fly     1 MASGGD---PKWQKDAADQNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKT 62
            |::|||   |..:           |||:.:|..||.|||.:.|:..|||.:.:.:.:||||..||
Human     1 MSAGGDFGNPLRK-----------FKLVFLGEQSVAKTSLITRFRYDSFDNTYQAIIGIDFLSKT 54

  Fly    63 VFRHDKRVKLQIWDTAGQERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNA 127
            ::..|..:.|::||||||||.|::...|.|.:...:::||:||.:||.....|:..::|....:.
Human    55 MYLEDGTIGLRLWDTAGQERLRSLIPRYIRDSAAAVVVYDITNVNSFQQTTKWIDDVRTERGSDV 119

  Fly   128 QVILVGNKCDMEDQRVISFERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESLDA 192
            .:.||||:.|:.|:|.:|.|.|.:.|..|.|.|.||.||...|||.:|.|:...:....|.
Human   120 IITLVGNRTDLADKRQVSVEEGERKAKGLNVTFIETRAKAGYNVKQLFRRVAAALPGMEST---- 180

  Fly   193 DPTLVGGGQKGQR--LTD------QPQGTPNANCNC 220
                    |.|.|  ::|      |.|......|:|
Human   181 --------QDGSREDMSDIKLEKPQEQTVSEGGCSC 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab3	NP_523687.1	Rab3	21..185	CDD:206657	63/163 (39%)
RAB6C	NP_115520.2	Required for centrosome localization	1..174		68/183 (37%)
		Rab6	14..174	CDD:206654	63/159 (40%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P20340	32..50		6/17 (35%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P20340	69..88		9/18 (50%)