Protein Alignment Rab3 and RAB7A

DIOPT Version :10

• Sequence 1: NP_523687.1
• Gene: Rab3 / 36127
• FlyBaseID: FBgn0005586
• Length: 220
• Species: Drosophila melanogaster
• Sequence 2: NP_004628.4
• Gene: RAB7A / 7879
• HGNCID: 9788
• Length: 207
• Species: Homo sapiens
• Alignment Length: 162
• Identity: 58/162 - (35%)
• Similarity: 102/162 - (62%)
• Gaps: 4/162 - (2%)

  Fly    21 MFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQERYRT 85
            :.|::|:|:|.|||||.:.:|.:..|::.:.:|:|.||..|.|...|:.|.:||||||||||:::
Human     8 LLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQS 72

  Fly    86 ITTAYYRGAMGFILMYDVTNEDSFNSVQDW----VTQIKTYSWDNAQVILVGNKCDMEDQRVISF 146
            :..|:||||...:|::|||..::|.::..|    :.|......:|...:::|||.|:|:::|.:.
Human    73 LGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATK 137

  Fly   147 ERGRQLADQLGVEFFETSAKENVNVKAVFERL 178
            ........:..:.:|||||||.:||:..|:.:
Human   138 RAQAWCYSKNNIPYFETSAKEAINVEQAFQTI 169

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab3	NP_523687.1	Rab3	21..185	CDD:206657	58/162 (36%)
RAB7A	NP_004628.4	Rab7	9..179	CDD:206655	58/161 (36%)
		Switch 1. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	28..41		2/12 (17%)
		Switch 2. /evidence=ECO:0000269|PubMed:15933719, ECO:0007744|PDB:1T91, ECO:0007744|PDB:1YHN	67..82		7/14 (50%)