Protein Alignment Rab3 and RAB2A

DIOPT Version :10

• Sequence 1: NP_523687.1
• Gene: Rab3 / 36127
• FlyBaseID: FBgn0005586
• Length: 220
• Species: Drosophila melanogaster
• Sequence 2: NP_002856.1
• Gene: RAB2A / 5862
• HGNCID: 9763
• Length: 212
• Species: Homo sapiens
• Alignment Length: 204
• Identity: 75/204 - (36%)
• Similarity: 117/204 - (57%)
• Gaps: 16/204 - (7%)

  Fly    18 FDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQER 82
            :.|:||.:|||::.|||:..|.::.|..|......|:|::|..:.:....|::|||||||||||.
Human     3 YAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIWDTAGQES 67

  Fly    83 YRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRVISFE 147
            :|:||.:|||||.|.:|:||:|..|:||.:..|:...:.:|..|..::|:|||.|:|.:|.:..|
Human    68 FRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNKSDLESRREVKKE 132

  Fly   148 RGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESL-----DADPTLVG--------- 198
            .|...|.:.|:.|.|||||...||:..|......|.:|:.|.:     :|:...:|
Human   133 EGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINNEANGIKIGPQHAATNAT 197

  Fly   199 --GGQKGQR 205
              |.|.||:
Human   198 HAGNQGGQQ 206

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab3	NP_523687.1	Rab3	21..185	CDD:206657	66/163 (40%)
RAB2A	NP_002856.1	PLN03108	1..188	CDD:178655	70/184 (38%)
		Required for interaction with PRKCI. /evidence=ECO:0000269|PubMed:14570876	2..19		7/15 (47%)
		Switch 1. /evidence=ECO:0000250|UniProtKB:P61106	37..42		2/4 (50%)
		Switch 2. /evidence=ECO:0000250|UniProtKB:P61106	63..72		5/8 (63%)