DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rab3 and RAB8B

DIOPT Version :9

Sequence 1:	NP_001356961.1	Gene:	Rab3 / 36127	FlyBaseID:	FBgn0005586	Length:	220	Species:	Drosophila melanogaster
Sequence 2:	NP_057614.1	Gene:	RAB8B / 51762	HGNCID:	30273	Length:	207	Species:	Homo sapiens

Alignment Length:	185	Identity:	93/185 - (50%)
Similarity:	139/185 - (75%)	Gaps:	1/185 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 QNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQ 80
            :.:||:||||:||:|.||||..|||:::|:|.:.|:||:|||||::|:....|::||||||||||
Human     3 KTYDYLFKLLLIGDSGVGKTCLLFRFSEDAFNTTFISTIGIDFKIRTIELDGKKIKLQIWDTAGQ 67

  Fly    81 ERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRVIS 145
            ||:|||||||||||||.:|:||:|||.||:::::|:..|:.::..:.:.:::||||||.|:|.:|
Human    68 ERFRTITTAYYRGAMGIMLVYDITNEKSFDNIKNWIRNIEEHASSDVERMILGNKCDMNDKRQVS 132

  Fly   146 FERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESLDADPTLVGGG 200
            .|||.:||...|::|.|||||.:.||:..|..|...|..|::..:: |....|.|
Human   133 KERGEKLAIDYGIKFLETSAKSSANVEEAFFTLARDIMTKLNRKMN-DSNSAGAG 186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rab3	NP_001356961.1	Rab3	21..185	CDD:206657	87/163 (53%)
RAB8B	NP_057614.1	Rab8_Rab10_Rab13_like	6..172	CDD:206659	89/165 (54%)
RAB8B	NP_057614.1	Effector region. /evidence=ECO:0000250	37..45		5/7 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910