Protein Alignment Rab3 and RAB35

DIOPT Version :10

• Sequence 1: NP_523687.1
• Gene: Rab3 / 36127
• FlyBaseID: FBgn0005586
• Length: 220
• Species: Drosophila melanogaster
• Sequence 2: NP_006852.1
• Gene: RAB35 / 11021
• HGNCID: 9774
• Length: 201
• Species: Homo sapiens
• Alignment Length: 201
• Identity: 88/201 - (43%)
• Similarity: 142/201 - (70%)
• Gaps: 9/201 - (4%)

  Fly    16 QNFDYMFKLLIIGNSSVGKTSFLFRYADDSFTSAFVSTVGIDFKVKTVFRHDKRVKLQIWDTAGQ 80
            :::|::|||||||:|.|||:|.|.|:||::|:.::::|:|:|||::||..:.::|||||||||||
Human     3 RDYDHLFKLLIIGDSGVGKSSLLLRFADNTFSGSYITTIGVDFKIRTVEINGEKVKLQIWDTAGQ 67

  Fly    81 ERYRTITTAYYRGAMGFILMYDVTNEDSFNSVQDWVTQIKTYSWDNAQVILVGNKCDMEDQRVIS 145
            ||:||||:.||||..|.|::||||:.:||.:|:.|:.:| ..:.|:...||||||.|..:::|:.
Human    68 ERFRTITSTYYRGTHGVIVVYDVTSAESFVNVKRWLHEI-NQNCDDVCRILVGNKNDDPERKVVE 131

  Fly   146 FERGRQLADQLGVEFFETSAKENVNVKAVFERLVDIICDKMSESLDADPTLVGGGQKGQRLTDQP 210
            .|...:.|.|:|::.|||||||||||:.:|..:.:::.....::|        ..|:.|:..|..
Human   132 TEDAYKFAGQMGIQLFETSAKENVNVEEMFNCITELVLRAKKDNL--------AKQQQQQQNDVV 188

  Fly   211 QGTPNA 216
            :.|.|:
Human   189 KLTKNS 194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rab3	NP_523687.1	Rab3	21..185	CDD:206657	81/163 (50%)
RAB35	NP_006852.1	Rab35	3..201	CDD:133310	88/201 (44%)
		Switch 1. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	30..42		3/11 (27%)
		Switch 2. /evidence=ECO:0000269|PubMed:30905672, ECO:0007744|PDB:6IF2, ECO:0007744|PDB:6IF3	64..80		12/15 (80%)