DRSC/TRiP Functional Genomics Resources

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Protein Alignment Elp2 and CIAO1

DIOPT Version :9

Sequence 1:NP_610600.1 Gene:Elp2 / 36123 FlyBaseID:FBgn0033540 Length:794 Species:Drosophila melanogaster
Sequence 2:XP_024309015.1 Gene:CIAO1 / 9391 HGNCID:14280 Length:372 Species:Homo sapiens


Alignment Length:358 Identity:89/358 - (24%)
Similarity:141/358 - (39%) Gaps:76/358 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   117 LLATAAADTTIKLWTFQDNNYVCFQTISLSDGFCFCLR-LQLLPKSNQVLLAFSGDDETVSLWSE 180
            |||:...|..|::|..:.::::|...  ||:|....:| :...|..|  .||.:..|.|..:|.:
Human    30 LLASCGGDRRIRIWGTEGDSWICKSV--LSEGHQRTVRKVAWSPCGN--YLASASFDATTCIWKK 90

  Fly   181 QVETAGEGDSLGRQFQRKHKLTGHEDWVRGLDFVVDGEDLLLASGSQDNFIRLWRIAPRSKEQMQ 245
            ..:          .|:....|.|||:.|:.:.:...|.  |||:.|:|..:.:|....||.:   
Human    91 NQD----------DFECVTTLEGHENEVKSVAWAPSGN--LLATCSRDKSVWVWEGEARSLQ--- 140

  Fly   246 ENRVDLHQLSHNDDEIKVEEKILQLGKEAW---YAVSLE--------SVLYGHEGWIYGVHWHKT 299
               ||...   .|..:.|.:::     .:|   ::.:::        |||..|...:..|.||  
Human   141 ---VDWEP---PDSPLCVPDRV-----GSWVPFFSPTVDEEDEYECVSVLNSHTQDVKHVVWH-- 192

  Fly   300 PDQELRLLSASIDKTVIIWAPTEEGIWLEEVRVGEVGGNSVGFYGGKFSGDGHSIMAHSYQGGFH 364
            |.||| |.|||.|.||.::. .||..|   |....:.|:....:...|...|..:.:.|......
Human   193 PSQEL-LASASYDDTVKLYR-EEEDDW---VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVR 252

  Fly   365 IWSQ--------------DPDRPQLWTPGVIVGGHYGEVRDLAWEHSGAYLMTASADQTTRLHAP 415
            ||.|              ||....:.|   :.|.|...:.|:||......|.||..|...|:   
Human   253 IWRQYLPGNEQGVACSGSDPSWKCICT---LSGFHSRTIYDIAWCQLTGALATACGDDAIRV--- 311

  Fly   416 WLQDGAN-----PTWHELAR-PQIHGYDMQALA 442
             .|:..|     ||:...|. .|.|..|:..:|
Human   312 -FQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVA 343

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Elp2NP_610600.1 WD40 <2..236 CDD:225201 31/119 (26%)
WD40 repeat 18..55 CDD:293791
WD40 50..412 CDD:295369 79/320 (25%)
WD40 repeat 104..145 CDD:293791 7/27 (26%)
WD40 repeat 150..202 CDD:293791 9/52 (17%)
WD40 repeat 209..281 CDD:293791 14/74 (19%)
WD40 237..741 CDD:225201 58/237 (24%)
WD40 repeat 291..331 CDD:293791 17/39 (44%)
WD40 repeat 337..382 CDD:293791 10/58 (17%)
WD40 repeat 389..412 CDD:293791 7/22 (32%)
WD40 552..790 CDD:295369
WD40 repeat 563..604 CDD:293791
WD40 repeat 609..652 CDD:293791
WD40 repeat 660..695 CDD:293791
WD40 repeat 702..758 CDD:293791
WD40 repeat 764..791 CDD:293791
CIAO1XP_024309015.1 WD40 17..365 CDD:238121 89/358 (25%)
WD40 repeat 19..58 CDD:293791 8/29 (28%)
WD40 repeat 65..103 CDD:293791 10/49 (20%)
WD40 repeat 108..180 CDD:293791 17/87 (20%)
WD40 repeat 187..224 CDD:293791 18/43 (42%)
WD40 repeat 230..281 CDD:293791 9/53 (17%)
WD40 repeat 288..332 CDD:293791 13/47 (28%)
WD40 repeat 339..364 CDD:293791 1/5 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0645
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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