DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elp2 and ELP2

DIOPT Version :9

Sequence 1:	NP_610600.1	Gene:	Elp2 / 36123	FlyBaseID:	FBgn0033540	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_011716.3	Gene:	ELP2 / 853114	SGDID:	S000003432	Length:	788	Species:	Saccharomyces cerevisiae

Alignment Length:	831	Identity:	261/831 - (31%)
Similarity:	414/831 - (49%)	Gaps:	141/831 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IAYGACNAIAIMDPKFQGNSAKVLFTLVEHTKRVNTVRWL-DCDKLLSGGDDAIAILWELDETGT 90
            :|:||...||:.|| .:.|:..|..||..|...|..||:: |.|.::|..:|....:|:
Yeast    30 VAFGAGKTIALWDP-IEPNNKGVYATLKGHEAEVTCVRFVPDSDFMVSASEDHHVKIWK------ 87

  Fly    91 TKSFTLKGHTSGVNTVDGIRQQDGSWLLATAA---------ADTTIKLW--TFQDNNYVCFQTIS 144
               ||...|...:.|:    |.....::|.:|         ||.||.:|  ..|::.:......:
Yeast    88 ---FTDYSHLQCIQTI----QHYSKTIVALSALPSLISVGCADGTISIWRQNIQNDEFGLAHEFT 145

  Fly   145 LSDGFCF--CLRLQLLPKSNQVLLAFSGDDETVSLWS--------EQVETAGEGDSLGRQFQRKH 199
            :..||.:  ||.|..: :..:.|||..|.:..|.:.|        |:.....|
Yeast   146 IKKGFFYPLCLSLSKV-EEKKYLLAIGGTNVNVFIASFILSDSGIEKCRVVAE------------ 197

  Fly   200 KLTGHEDWVRGLDF---VVDGEDLLLASGSQDNFIRLWRIAPRSKEQMQENRVDLHQLS------ 255
             |.||||||:.|.|   ...| |.||.|||||.:||||||  |..:.:.::..|..:|:
Yeast   198 -LEGHEDWVKSLAFRHQETPG-DYLLCSGSQDRYIRLWRI--RINDLIDDSEEDSKKLTLLSNKQ 258

  Fly   256 ---HNDDEIKVEEKILQLGKEAWYAVSLESVLYGHEGWIYGVHWHKTPDQELRLLSASIDKTVII 317
               ..|||::|             .::.|:::.||:.||..:.||   :..|:||:|:.|.::::
Yeast   259 YKFQIDDELRV-------------GINFEALIMGHDDWISSLQWH---ESRLQLLAATADTSLMV 307

  Fly   318 WAPTE-EGIWLEEVRVGEVG--------GNSVGFYGGK-FSGDGHS-IMAHSYQGGFHIWSQDPD 371
            |.|.| .|||:..:|:||:.        |:|.||:... |:.:... .:.:...|.:.:|:...:
Yeast   308 WEPDETSGIWVCSLRLGEMSSKGASTATGSSGGFWSCLWFTHERMDFFLTNGKTGSWRMWATKDN 372

  Fly   372 RPQLWTPGVI------VGGHYGEVRDLAWEHSGAYLMTASADQTTRLHAPWLQDGAN-----PTW 425
                    :|      :.|...:|.|:||..||.||:..|.||||||.|||:.|.:.     .||
Yeast   373 --------IICDQRLGISGATKDVTDIAWSPSGEYLLATSLDQTTRLFAPWIYDASGRKREIATW 429

  Fly   426 HELARPQIHGYDMQALALLSRYKFASGAEEKIVRTFQAPANFIENFRHISGIENDDAGDVLLDSL 490
            ||.:|||||||||..:..::..:|.||.:|||:|:|..|.......:...||:.::..:     :
Yeast   430 HEFSRPQIHGYDMICVETVTDTRFVSGGDEKILRSFDLPKGVAGMLQKFVGIQFEEKSE-----M 489

  Fly   491 PKGASVPSLGLSNKAVYKVDSEVESTSKTSKDEYPDNYFVPIALETPPQEETLMQNTLWPELQKL 555
            |..|:||.|||||||.....:|.:...:....|.||.......||.||.|:.|.::.||||::||
Yeast   490 PDSATVPVLGLSNKAGEDDANEDDEEEEGGNKETPDITDPLSLLECPPMEDQLQRHLLWPEVEKL 554

  Fly   556 YGHGYEIFALAATADGSLLASTCKASNAEHAQIILWNPSNWKQIQ-KLSGHQLTVTQLSFSPDSR 619
            ||||:||..|..:.|..|:||.|:::|.::|.|.:::..||.:|: .|..|.||:|:|.||.|.:
Yeast   555 YGHGFEITCLDISPDQKLIASACRSNNVQNAVIRIFSTENWLEIKPALPFHSLTITRLKFSKDGK 619

  Fly   620 YLLSVSRDRRWCLYERQDSSVSYQLVASTDKSNGVHTRIIWSCDWS--HDGQFFVTSSRDGKVVV 682
            :||||.|||:|.|:||.....:::|....:|.   ||||||..||:  ..|..|||:|||..|.|
Yeast   620 FLLSVCRDRKWALWERNMEDNTFELRFKNEKP---HTRIIWDADWAPLEFGNVFVTASRDKTVKV 681

  Fly   683 WKKEEDCKESSLNGWQANGVLELK---NESITAVAFSNSYLSGTDDTYILALGTETGLIKIYQFV 744
            |:.:::..:        :.|||..   .:::||::..:|.:.   :..::::|.|.|.|.:|.:.
Yeast   682 WRHQKEPAD--------DYVLEASIKHTKAVTAISIHDSMIR---EKILISVGLENGEIYLYSYT 735

  Fly   745 RGAWKLLSDLNKSQAHHLTVRRLQF----RPGKQLQLASCGEDHLVRIYDI 791
            .|.::|::.||:.......:.||::    |.|| |.|.....|...|||.:
Yeast   736 LGKFELITQLNEDITPADKITRLRWSHLKRNGK-LFLGVGSSDLSTRIYSL 785

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elp2	NP_610600.1	WD40	<2..236	CDD:225201	68/233 (29%)
		WD40 repeat	18..55	CDD:293791	11/27 (41%)
		WD40	50..412	CDD:295369	111/412 (27%)
		WD40 repeat	104..145	CDD:293791	10/51 (20%)
		WD40 repeat	150..202	CDD:293791	11/61 (18%)
		WD40 repeat	209..281	CDD:293791	24/83 (29%)
		WD40	237..741	CDD:225201	175/540 (32%)
		WD40 repeat	291..331	CDD:293791	14/40 (35%)
		WD40 repeat	337..382	CDD:293791	8/52 (15%)
		WD40 repeat	389..412	CDD:293791	13/22 (59%)
		WD40	552..790	CDD:295369	85/247 (34%)
		WD40 repeat	563..604	CDD:293791	13/41 (32%)
		WD40 repeat	609..652	CDD:293791	18/42 (43%)
		WD40 repeat	660..695	CDD:293791	13/36 (36%)
		WD40 repeat	702..758	CDD:293791	15/58 (26%)
		WD40 repeat	764..791	CDD:293791	11/30 (37%)
ELP2	NP_011716.3	WD40	52..413	CDD:238121	113/414 (27%)
		WD40 repeat	62..102	CDD:293791	12/52 (23%)
		WD40 repeat	108..144	CDD:293791	8/35 (23%)
		WD40 repeat	153..199	CDD:293791	11/59 (19%)
		WD40 repeat	206..264	CDD:293791	20/60 (33%)
		WD40 repeat	284..322	CDD:293791	14/40 (35%)
		WD40 repeat	341..382	CDD:293791	5/48 (10%)
		WD40 repeat	388..412	CDD:293791	14/23 (61%)
		WD40 repeat	443..534	CDD:293791	26/95 (27%)
		WD40	554..>786	CDD:421866	85/247 (34%)
		WD40 repeat	561..604	CDD:293791	14/42 (33%)
		WD40 repeat	610..651	CDD:293791	17/40 (43%)
		WD40 repeat	656..698	CDD:293791	17/49 (35%)
		WD40 repeat	705..746	CDD:293791	10/43 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	97	1.000	Domainoid score	I1626
eggNOG	1	0.900	-	-		E1_KOG1063
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6019
Inparanoid	1	1.050	366	1.000	Inparanoid score	I372
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55164
OrthoFinder	1	1.000	-	-		FOG0004188
OrthoInspector	1	1.000	-	-		oto99850
orthoMCL	1	0.900	-	-		OOG6_103229
Panther	1	1.100	-	-	LDO	PTHR44111
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R391
SonicParanoid	1	1.000	-	-		X2935
TreeFam	1	0.960	-	-
	14	13.860