DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elp2 and ELP2

DIOPT Version :9

Sequence 1:	NP_610600.1	Gene:	Elp2 / 36123	FlyBaseID:	FBgn0033540	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_001185180.1	Gene:	ELP2 / 841378	AraportID:	AT1G49540	Length:	840	Species:	Arabidopsis thaliana

Alignment Length:	871	Identity:	294/871 - (33%)
Similarity:	436/871 - (50%)	Gaps:	117/871 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQVENLHTSVACNRCTECADWGPNGWIAYGACNAIAIMDPKFQGNSAKVLFTLVEHTKRVNTVRW 65
            ::.:.:.....|||......||.:|.:::||.||:|:..||    :|::|.||..|...||...|
plant     7 VEAKRVFIGAGCNRVVNNVSWGASGLVSFGAQNAVAVFCPK----TAQILTTLPGHKASVNCTHW 67

  Fly    66 LDCDK------------LLSGGDDAIAILWELDETGTTKSF--TLK---GHTSGVNTVDGIRQQD 113
            |...|            ||||..|.|.|||||......:.:  .|:   .|..||..:......:
plant    68 LPTSKFAFKAKKLDRQYLLSGDSDGIIILWELSTLNNDQQWRHVLQLPLSHKKGVTCITAYMVSE 132

  Fly   114 GSWLLATAAADTTIKLWTF-------QDNNYVCFQTISLSDGFCFCLRLQLLPKS-NQVLLAFSG 170
            ...:.|:|::|..:.:|..       ::...||..:|.:.......|.|..||:: .:..||..|
plant   133 TDAMFASASSDGVVNVWDVSFPSQPSEECKVVCLDSICVDTKAIVTLSLAELPQNPGRFALALGG 197

  Fly   171 DDETVSLWSEQVETAGEGDSLGRQFQRKHKLTGHEDWVRGLDFVVD-------GEDLLLASGSQD 228
            .|..:.|:|        |:..|: |....:|.||.||:|.|||.:.       ...::|.|.|||
plant   198 LDNKIKLYS--------GERTGK-FTSVCELKGHTDWIRSLDFSLPLHTTEEIPNSIMLVSSSQD 253

  Fly   229 NFIRLWRIAPRSKEQMQENRVDLHQLSHNDDEIKVEEKILQLGKEAWYAVSLESVLYGHEGWIYG 293
            ..||:|::............:.|...        :|..:...|... |.:|:||||.|||.|:|.
plant   254 KVIRIWKLVLVGDVGSWRREITLASY--------IEGPVFVSGTFT-YQISVESVLIGHEDWVYS 309

  Fly   294 VHWHK----------TPDQELRLLSASIDKTVIIWAPTEE-GIWLEEVRVGEVGGNSVGFYGGKF 347
            |.|..          ...|.|.:||||:|||::||.|.:: |:|:..|.|||:...::|||||.:
plant   310 VEWQPPVIDFIDGRLVNHQPLSILSASMDKTMMIWRPEKKTGVWVNVVCVGELSHCALGFYGGHW 374

  Fly   348 SGDGHSIMAHSYQGGFHIW-----SQDPDRPQLWTPGVIVGGHYGEVRDLAWEHSGAYLMTASAD 407
            |.:..||:||.|.|.||:|     |::.:.   |....:..||:..|.|:.|..:|.||::.|.|
plant   375 SPNSLSILAHGYGGAFHLWRNVSSSKESEN---WQMQKVPSGHFAAVTDVTWARTGEYLLSVSQD 436

  Fly   408 QTTRLHAPWLQDGANPT----WHELARPQIHGYDMQALALL---SRYKFASGAEEKIVRTFQAPA 465
            ||||:.:.|..|..|..    ||||||||:||:|:..:|::   ..::|.||||||:||.|:||.
plant   437 QTTRVFSAWKNDEGNEAEDEHWHELARPQVHGHDINCVAMVQGKGNHRFVSGAEEKVVRVFEAPL 501

  Fly   466 NFIENFRH-ISGIENDDAGDVLLDSLPKGASVPSLGLSNKAVYKVDSEVESTSKTSKDEYPDNY- 528
            :|::...| .:|.|.....|:..|....||::.:||||.|.:| :.|..|...:....|..|.:
plant   502 SFLKTLNHTCAGGEGSFPEDLQADVQVLGANMSALGLSQKPIY-LHSSSEPLERNGGGEGLDTFE 565

  Fly   529 ----FVPIALETPPQEETLMQNTLWPELQKLYGHGYEIFALAATADGSLLASTCKASNAEHAQII 589
                ..|..|:.||.|:.|..:|||||..||||||.|:|:|.:...|:|:||:|||.:|..|:|.
plant   566 TVPEAAPAELKEPPIEDQLAFHTLWPESHKLYGHGNELFSLCSDHKGNLVASSCKAQSASMAEIW 630

  Fly   590 LWNPSNWKQIQKLSGHQLTVTQLSFSPDSRYLLSVSRDRRWCLY--ERQDS-SVSYQLVASTDKS 651
            ||....||.:.:|..|.||||.|.||.|...||||||||.:.::  :|.|: .||::|:|..:
plant   631 LWEVGTWKAVGRLQSHSLTVTHLEFSYDDTLLLSVSRDRHFSVFSIQRTDNGEVSHKLMAKVE-- 693

  Fly   652 NGVHTRIIWSCDWSHDGQFFVTSSRDGKVVVWKKEEDCKESSLNGWQANGVLELKNESITAVAFS 716
              .|.||||:|.|:..|..|.|||||..|.:|..|.|.:...:.      ||.....|:||||::
plant   694 --AHKRIIWACSWNPFGHQFATSSRDKTVKIWSVENDARIKQIL------VLPPFGSSVTAVAWT 750

  Fly   717 NSYLSGTDDTYILALGTETGLI-----KIYQFVRGAW---KLLSDLNKSQAHHLTVRRLQFRPGK 773
            .  |...:.:..:|:|.|:|||     ||.:...|..   .|...|.....|...|.||.:||.:
plant   751 G--LDRNEKSGCVAVGMESGLIELSNVKIIETEEGTTATAALALRLEPFMCHVSAVNRLAWRPTE 813

  Fly   774 QLQ-------LASCGEDHLVRIYDIK 792
            :.:       |.|||:|:.||:::.|
plant   814 KCESNQSLRWLTSCGDDNCVRVFNFK 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elp2	NP_610600.1	WD40	<2..236	CDD:225201	75/265 (28%)
		WD40 repeat	18..55	CDD:293791	14/36 (39%)
		WD40	50..412	CDD:295369	125/409 (31%)
		WD40 repeat	104..145	CDD:293791	7/47 (15%)
		WD40 repeat	150..202	CDD:293791	13/52 (25%)
		WD40 repeat	209..281	CDD:293791	17/78 (22%)
		WD40	237..741	CDD:225201	201/540 (37%)
		WD40 repeat	291..331	CDD:293791	17/50 (34%)
		WD40 repeat	337..382	CDD:293791	17/49 (35%)
		WD40 repeat	389..412	CDD:293791	11/22 (50%)
		WD40	552..790	CDD:295369	97/255 (38%)
		WD40 repeat	563..604	CDD:293791	17/40 (43%)
		WD40 repeat	609..652	CDD:293791	20/45 (44%)
		WD40 repeat	660..695	CDD:293791	14/34 (41%)
		WD40 repeat	702..758	CDD:293791	19/63 (30%)
		WD40 repeat	764..791	CDD:293791	12/33 (36%)
ELP2	NP_001185180.1	WD40	54..443	CDD:295369	125/409 (31%)
		WD40 repeat	63..116	CDD:293791	16/52 (31%)
		WD40	69..>502	CDD:225201	145/453 (32%)
		WD40 repeat	122..154	CDD:293791	5/31 (16%)
		WD40 repeat	162..220	CDD:293791	16/66 (24%)
		WD40 repeat	226..266	CDD:293791	12/39 (31%)
		WD40 repeat	274..301	CDD:293791	8/35 (23%)
		WD40	299..724	CDD:295369	176/432 (41%)
		WD40 repeat	307..344	CDD:293791	12/36 (33%)
		WD40 repeat	354..406	CDD:293791	20/54 (37%)
		WD40 repeat	414..465	CDD:293791	22/50 (44%)
		WD40 repeat	471..497	CDD:293791	10/25 (40%)
		WD40	<588..>839	CDD:225201	102/262 (39%)
		WD40 repeat	651..694	CDD:293791	19/46 (41%)
		WD40 repeat	699..742	CDD:293791	17/48 (35%)
		WD40 repeat	750..781	CDD:293791	9/32 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	138	1.000	Domainoid score	I1572
eggNOG	1	0.900	-	-		E1_KOG1063
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6019
Inparanoid	1	1.050	448	1.000	Inparanoid score	I392
OMA	1	1.010	-	-		QHG55164
OrthoDB	1	1.010	-	-		D461632at2759
OrthoFinder	1	1.000	-	-		FOG0004188
OrthoInspector	1	1.000	-	-		oto3173
orthoMCL	1	0.900	-	-		OOG6_103229
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2935
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740