DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elp2 and Elp2

DIOPT Version :9

Sequence 1:	NP_610600.1	Gene:	Elp2 / 36123	FlyBaseID:	FBgn0033540	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	NP_067423.2	Gene:	Elp2 / 58523	MGIID:	1889642	Length:	831	Species:	Mus musculus

Alignment Length:	862	Identity:	357/862 - (41%)
Similarity:	499/862 - (57%)	Gaps:	114/862 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VENLHTSVACNRCTECADW--GPNGWIAYGACNAIAIMDPKFQGNSAKVLFT-LVEHTKRVNTVR 64
            :|..|.....||......|  ||.|.:|:|...::.:.||:     .||:.| |..||.|||.::
Mouse     6 LEVSHVFCCPNRVRGALSWNTGPGGLLAFGTSCSVVLYDPQ-----KKVVITNLNGHTARVNCLQ 65

  Fly    65 WL------DCDKLLSGGDDAIAILWELDETGTTKSFTLKGHTSGVNTVDGIRQQDGS-----WLL 118
            |:      ..::|:|||.|...|.|||:.....||..|:||...|..|..|.|...|     .|:
Mouse    66 WIRTEDGSPSNELVSGGSDNRVIHWELENNQVLKSVRLQGHEGPVCAVHAIYQSGPSEGEQHALI 130

  Fly   119 ATAAADTTIKLWTFQDNNYVCFQTISLSDGFCFCLRLQLLPKSNQVLLAFSGDDETVSLWSEQVE 183
            |:||:|:|:::|:.:.:.....||:|..|||...:.|.:||.:|..:||...||..:.|:.:|.:
Mouse   131 ASAASDSTVRIWSKKGSEVKYLQTLSFRDGFVLSVCLAILPGTNVPVLACGDDDCRIHLYIQQDD 195

  Fly   184 TAGEGDSLGRQFQRKHKLTGHEDWVRGLDFVVDGEDLLLASGSQDNFIRLWRI--APRSKEQMQE 246
                      |||:...|.|||||:||:::...|.||.|||.|||..||:||:  .|.|.|.
Mouse   196 ----------QFQKALSLCGHEDWIRGVEWATFGRDLFLASCSQDCLIRIWRLYMKPASFET--- 247

  Fly   247 NRVDLHQLSHNDDEIKVEEKILQL---GKEAWYAVSLESVLYGHEGWIYGVHWHKT------PDQ 302
                      .|..::::|....:   |.....||:||:||.|||.|:..|||..:      ..|
Mouse   248 ----------KDGSLRLKENTFTIKDGGVRTTVAVTLETVLAGHENWVNAVHWQPSFYKDGVLQQ 302

  Fly   303 ELRLLSASIDKTVIIWAPTEE-GIWLEEVRVGEVGGNSVGFYGGKFSGDGHSIMAHSYQGGFHIW 366
            .:||||||:|||:|:|||.|| |:|||:|||||||||::|||..:|..:|..|:||::.|..|:|
Mouse   303 PVRLLSASMDKTMILWAPDEESGVWLEQVRVGEVGGNTLGFYDCQFGENGTMIIAHAFHGALHLW 367

  Fly   367 SQDPDRPQLWTPGVIVGGHYGEVRDLAWEHSGAYLMTASADQTTRLHAPW----LQDGANPTWHE 427
            .|....|:.|.|.:::.||:..|:||.|:..|.:::|.|.||||||.|||    .:|.:..||||
Mouse   368 KQSTVNPRQWAPEIVISGHFDGVQDLMWDPEGEFIITTSTDQTTRLFAPWKKKDQKDRSQVTWHE 432

  Fly   428 LARPQIHGYDMQALALLSRYKFASGAEEKIVRTFQAPANFIENFRHISGIENDDAGDVLLD--SL 490
            :||||||||:::.||::.|::|.|||:||::|.|.||.||:|||   |.|.......:|.|  .|
Mouse   433 IARPQIHGYNIKCLAMIDRFQFVSGADEKVLRVFSAPRNFVENF---SVISRQSLSHMLCDDQDL 494

  Fly   491 PKGASVPSLGLSNKAVYKVDSEVESTSKTSKDEY-------PDNYFVPIALETPPQEETLMQNTL 548
            |:||:||:|||||||:::.|.   ::....:||.       |...|.|..|..||.|:.|:||||
Mouse   495 PEGATVPALGLSNKALFQGDI---ASQPFEEDELISPAFGSPQVTFQPAVLNEPPTEDHLLQNTL 556

  Fly   549 WPELQKLYGHGYEIFALAATADGSLLASTCKASNAEHAQIILWNPSNWKQIQKLSGHQLTVTQLS 613
            |||:||||||||||..:|.....:||||.||||..|||.||||:.::|||:|.|:.|.|||||::
Mouse   557 WPEIQKLYGHGYEIVCVACNNSKTLLASACKASQKEHAAIILWSTASWKQVQSLAFHTLTVTQMT 621

  Fly   614 FSPDSRYLLSVSRDRRWCLYERQDSSVS-----YQLVASTDKSNGVHTRIIWSCDWSHDGQFFVT 673
            ||||.::||:|||||.|.|::|||::.|     :.|.|.|:|...||:|||||||||.|.::|.|
Mouse   622 FSPDDKFLLAVSRDRTWSLWKRQDATSSEFDPFFSLFAFTNKITSVHSRIIWSCDWSPDNKYFFT 686

  Fly   674 SSRDGKVVVWKKEEDCKESSLNGWQ-----ANGVLELKNESITAVAFSNSYLSGTDDTYILALGT 733
            .|||.|||||   .:|| ||.|..:     .:.:|:: ..|:|||  |...:......||:|:|.
Mouse   687 GSRDKKVVVW---GECK-SSHNPMEHPIRPCSSILDV-GSSVTAV--SVCPVLNPAQRYIVAIGL 744

  Fly   734 ETGLIKIYQFVR-----GAWKLLSDLNKSQAHHLTVRRL------------------QFRPGKQ- 774
            |:|.|.||.:.:     ..|....:.|.||:|.|.:|||                  |...|.:
Mouse   745 ESGKICIYSWNKTNQEINDWTSCVETNPSQSHSLGIRRLCWKSCSDDDDDDDDDDTEQSEEGPEW 809

  Fly   775 LQLASCGEDHLVRIYDI 791
            |..|||||||.|:||.:
Mouse   810 LHFASCGEDHTVKIYRV 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elp2	NP_610600.1	WD40	<2..236	CDD:225201	87/246 (35%)
		WD40 repeat	18..55	CDD:293791	12/39 (31%)
		WD40	50..412	CDD:295369	150/385 (39%)
		WD40 repeat	104..145	CDD:293791	13/45 (29%)
		WD40 repeat	150..202	CDD:293791	13/51 (25%)
		WD40 repeat	209..281	CDD:293791	23/76 (30%)
		WD40	237..741	CDD:225201	245/536 (46%)
		WD40 repeat	291..331	CDD:293791	23/46 (50%)
		WD40 repeat	337..382	CDD:293791	17/44 (39%)
		WD40 repeat	389..412	CDD:293791	11/22 (50%)
		WD40	552..790	CDD:295369	121/271 (45%)
		WD40 repeat	563..604	CDD:293791	21/40 (53%)
		WD40 repeat	609..652	CDD:293791	24/47 (51%)
		WD40 repeat	660..695	CDD:293791	21/34 (62%)
		WD40 repeat	702..758	CDD:293791	17/60 (28%)
		WD40 repeat	764..791	CDD:293791	16/45 (36%)
Elp2	NP_067423.2	WD40	54..415	CDD:238121	150/384 (39%)
		WD 1	56..100		18/49 (37%)
		WD40 repeat	61..104	CDD:293791	18/48 (38%)
		WD40	94..>467	CDD:225201	162/393 (41%)
		WD 2	105..152		16/51 (31%)
		WD40 repeat	112..156	CDD:293791	16/48 (33%)
		WD 3	158..200		12/41 (29%)
		WD40 repeat	162..204	CDD:293791	11/41 (27%)
		WD 4	205..246		22/42 (52%)
		WD40 repeat	210..279	CDD:293791	22/73 (30%)
		WD 5	280..328		29/54 (54%)
		WD40 repeat	285..318	CDD:293791	18/38 (47%)
		WD 6	338..377		16/38 (42%)
		WD40 repeat	344..383	CDD:293791	15/38 (39%)
		WD 7	385..424		19/42 (45%)
		WD40 repeat	390..414	CDD:293791	10/23 (43%)
		WD 8	438..476		20/37 (54%)
		WD40 repeat	443..543	CDD:293791	44/108 (41%)
		WD40	<554..827	CDD:225201	123/275 (45%)
		WD40	<559..825	CDD:295369	119/270 (44%)
		WD 9	565..609		22/43 (51%)
		WD40 repeat	570..612	CDD:293791	22/41 (54%)
		WD 10	612..651		22/43 (51%)
		WD 11	667..706		18/43 (42%)
		WD40 repeat	673..704	CDD:293791	15/35 (43%)
		WD40 repeat	713..772	CDD:293791	22/81 (27%)
		WD 12	718..762		13/48 (27%)
		WD 13	775..831		12/21 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831062
Domainoid	1	1.000	181	1.000	Domainoid score	I3471
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6019
Inparanoid	1	1.050	605	1.000	Inparanoid score	I929
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55164
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004188
OrthoInspector	1	1.000	-	-		oto94102
orthoMCL	1	0.900	-	-		OOG6_103229
Panther	1	1.100	-	-	LDO	PTHR44111
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R391
SonicParanoid	1	1.000	-	-		X2935
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.930