DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Elp2 and elp2

DIOPT Version :9

Sequence 1:	NP_610600.1	Gene:	Elp2 / 36123	FlyBaseID:	FBgn0033540	Length:	794	Species:	Drosophila melanogaster
Sequence 2:	XP_012820102.2	Gene:	elp2 / 548516	XenbaseID:	XB-GENE-5752362	Length:	832	Species:	Xenopus tropicalis

Alignment Length:	855	Identity:	365/855 - (42%)
Similarity:	526/855 - (61%)	Gaps:	106/855 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 VENLHTSVACNRCTECADWGPNGWIAYGACNAIAIMDPKFQGNSAKVLFTLVEHTKRVNTVRWL- 66
            |:..|.:.:.|||..|..|...|.:|...|::||:.||  |.|  .|:.||..||.|||.|.|:
Frog    13 VQLAHAAFSVNRCPNCVSWSRTGILACATCHSIALYDP--QKN--VVISTLNGHTGRVNCVHWVQ 73

  Fly    67 --DCD---KLLSGGDDAIAILWELDETGTTKSFTLKGHTSGVNTVDGI--RQQDGSWLLATAAAD 124
              ||.   :|:|||.|...|:|.:::....:....:|||..||.|..:  ::.:...|:.:||:|
Frog    74 KNDCSAETELVSGGSDKKVIIWAIEKNKCEQPVAAEGHTEVVNAVHAVYTQRSENELLIVSAASD 138

  Fly   125 TTIKLWTFQDNNYVCFQTISLSDGFCFCLRLQLLPKSNQVLLAFSGDDETVSLWSEQVETAGEGD 189
            .|::||..::....|.||:|...||...:.:..||.|...:||...||..:.|:..|.|
Frog   139 CTVRLWLRRNVKTECLQTLSFGKGFVLDVCISFLPGSLVPVLACGADDSRIHLYVLQNE------ 197

  Fly   190 SLGRQFQRKHKLTGHEDWVRGLDFVVDGEDLLLASGSQDNFIRLWRIAPRSKEQMQENRVDLHQL 254
                ||::...|.|||||:||:::.|.|::|.|||.:||..||:|:|   .::..:||
Frog   198 ----QFEKTQVLHGHEDWIRGVEWAVTGQNLFLASCAQDCLIRIWKI---FRKTAKEN------- 248

  Fly   255 SHNDDE--IKVEEKILQLGK---EAWYAVSLESVLYGHEGWIYGVHWHKTPD------QELRLLS 308
            |..:||  ||::|.|.::.:   |..|||:||:||.|||..||.|||..:..      |.:.|||
Frog   249 SKTEDENSIKLKENIFKVKEKDTETSYAVTLETVLTGHENSIYAVHWQPSFSRDGSIVQPMSLLS 313

  Fly   309 ASIDKTVIIWAPTEE-GIWLEEVRVGEVGGNSVGFYGGKFSGDGHSIMAHSYQGGFHIWSQDPDR 372
            ||:|||:|:|.|.|| |:|||:|||||||||::||.|.:||.|...|:||::.|..|:||:.|::
Frog   314 ASMDKTMILWEPDEESGVWLEQVRVGEVGGNTLGFLGCQFSPDKSMILAHAFHGALHLWSRAPNK 378

  Fly   373 PQLWTPGVIVGGHYGEVRDLAWEHSGAYLMTASADQTTRLHAPWLQDG-ANPTWHELARPQIHGY 436
            ...|.|.||:.||:..|:|:.|:..|.:::|.||||||||..||.:.| ::.||||:||||||||
Frog   379 QNEWIPMVIISGHFDSVQDMRWDPDGQFVITVSADQTTRLFGPWKKKGQSHVTWHEIARPQIHGY 443

  Fly   437 DMQALALLSRYKFASGAEEKIVRTFQAPANFIENFRHISGIE------NDDAGDVLLDSLPKGAS 495
            |||.||::.|::|.|||:||::|.|.||.||||||.:||.|.      |:|.      :||:||:
Frog   444 DMQCLAMIGRFQFVSGADEKVLRVFAAPRNFIENFSNISCISVEKLLLNEDT------NLPEGAT 502

  Fly   496 VPSLGLSNKAVYKVDSEVESTSKTSK-----DEYPDNYFVPIALETPPQEETLMQNTLWPELQKL 555
            ||:||||||||:..:..::||.:..|     ::|....|.|:.|..||.|:.|:|||||||:|||
Frog   503 VPALGLSNKAVFHGEILIQSTQEEGKYNSVSEQYSQPNFQPLNLTEPPTEDHLLQNTLWPEVQKL 567

  Fly   556 YGHGYEIFALAATADGSLLASTCKASNAEHAQIILWNPSNWKQIQKLSGHQLTVTQLSFSPDSRY 620
            |||||||||:|..:..:::||.||||..|||.||||:.::|||:|.||.|.|||||::||||..:
Frog   568 YGHGYEIFAVACNSAKTVIASACKASKREHAAIILWSTTSWKQLQSLSYHNLTVTQMAFSPDDEF 632

  Fly   621 LLSVSRDRRWCLYERQD------SSVSYQLVASTDKSNGVHTRIIWSCDWSHDGQFFVTSSRDGK 679
            ||.|||||.|.|:::|:      :..::.|.|||||::.||:||||:|||:.|.::|||.|||.|
Frog   633 LLVVSRDRNWSLWKKQEGIPEQTAEPTFTLYASTDKNSCVHSRIIWACDWTPDSKYFVTGSRDKK 697

  Fly   680 VVVWKKEEDCKESSLNGWQANGVLEL------KNESITAVAFSNSYLSGTDDTYILALGTETGLI 738
            |:||   .||...|:|..:::.::..      ..:|||||  |.|.:...|.:||:|:|.:.|:|
Frog   698 VIVW---GDCSLPSMNEEKSSALIRPCSSLLDTGDSITAV--SVSQVLALDGSYIIAVGLDCGII 757

  Fly   739 KIYQFVRGAWK---LLSDLNKSQA-------HHLTVRRLQFRP------------GKQLQLASCG 781
            ::|:     ||   .::|..|..|       |.|||::|.:|.            |..:||||||
Frog   758 QLYK-----WKHSGTVNDWLKCLAMDQSLLSHTLTVKQLCWRSCLGRAGHDDRDNGDWIQLASCG 817

  Fly   782 EDHLVRIYDI 791
            .||.|:|:|:
Frog   818 ADHCVKIFDV 827

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Elp2	NP_610600.1	WD40	<2..236	CDD:225201	85/240 (35%)
		WD40 repeat	18..55	CDD:293791	14/36 (39%)
		WD40	50..412	CDD:295369	152/381 (40%)
		WD40 repeat	104..145	CDD:293791	12/42 (29%)
		WD40 repeat	150..202	CDD:293791	12/51 (24%)
		WD40 repeat	209..281	CDD:293791	27/76 (36%)
		WD40	237..741	CDD:225201	255/539 (47%)
		WD40 repeat	291..331	CDD:293791	23/46 (50%)
		WD40 repeat	337..382	CDD:293791	19/44 (43%)
		WD40 repeat	389..412	CDD:293791	11/22 (50%)
		WD40	552..790	CDD:295369	119/271 (44%)
		WD40 repeat	563..604	CDD:293791	21/40 (53%)
		WD40 repeat	609..652	CDD:293791	23/48 (48%)
		WD40 repeat	660..695	CDD:293791	18/34 (53%)
		WD40 repeat	702..758	CDD:293791	19/64 (30%)
		WD40 repeat	764..791	CDD:293791	14/38 (37%)
elp2	XP_012820102.2	WD40 repeat	28..61	CDD:293791	14/36 (39%)
		WD40	56..419	CDD:238121	153/382 (40%)
		WD40 repeat	67..110	CDD:293791	12/42 (29%)
		WD40 repeat	126..158	CDD:293791	10/31 (32%)
		WD40 repeat	164..206	CDD:293791	12/51 (24%)
		WD40 repeat	212..284	CDD:293791	30/81 (37%)
		WD40 repeat	290..323	CDD:293791	15/32 (47%)
		WD40 repeat	349..388	CDD:293791	15/38 (39%)
		WD40 repeat	395..419	CDD:293791	12/23 (52%)
		WD40 repeat	445..496	CDD:293791	26/56 (46%)
		WD40 repeat	504..548	CDD:293791	16/43 (37%)
		WD40	<563..826	CDD:421866	120/272 (44%)
		WD40 repeat	574..616	CDD:293791	22/41 (54%)
		WD40 repeat	622..672	CDD:293791	22/49 (45%)
		WD40 repeat	677..719	CDD:293791	20/44 (45%)
		WD40 repeat	732..765	CDD:293791	15/39 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	199	1.000	Domainoid score	I3006
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H6019
Inparanoid	1	1.050	651	1.000	Inparanoid score	I784
OMA	1	1.010	-	-		QHG55164
OrthoDB	1	1.010	-	-		D279631at33208
OrthoFinder	1	1.000	-	-		FOG0004188
OrthoInspector	1	1.000	-	-		otm48842
Panther	1	1.100	-	-	LDO	PTHR44111
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R391
SonicParanoid	1	1.000	-	-		X2935
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110