Protein Alignment Elp2 and elpc-2

DIOPT Version :10

• Sequence 1: NP_610600.1
• Gene: Elp2 / 36123
• FlyBaseID: FBgn0033540
• Length: 794
• Species: Drosophila melanogaster
• Sequence 2: NP_499648.3
• Gene: elpc-2 / 176687
• WormBaseID: WBGene00013738
• Length: 778
• Species: Caenorhabditis elegans
• Alignment Length: 838
• Identity: 274/838 - (32%)
• Similarity: 426/838 - (50%)
• Gaps: 109/838 - (13%)

  Fly     1 MQVENLHTSVACN---RCTECADWGPNGWIAYGACNAIAIMDPKFQGNSAKVLFTLVE--HTKRV 60
            |::|....|.:.|   .|.......|  .:||.:...||:.......:...|:.:..|  |.|.:
 Worm     1 MKIEEEFISASVNPRSHCLTACKTAP--LVAYASSLQIAVQTIPKDDSEVGVIKSTSERRHQKPI 63

  Fly    61 NTVRWLD-----CDKLLSGGDDAIAILWELDETGTTKSFTLKGHTSGVNTVDGIRQQDGSWLLAT 120
            ..::.|.     .|:.::||.|:..:||:|..........|.|....|.:|.|. .:||..::|.
 Worm    64 TVLKRLKSSEIVADEFVTGGVDSRVVLWKLRGEHVEYVADLTGCDGSVGSVCGC-VEDGRKVVAA 127

  Fly   121 AAADTTIKLWTFQDNNYVCFQTISLSD------------GFCFCLRLQLLPKSNQVLLAFSGDDE 173
            |....|       .|.:..:.|.|:.|            .|..|  |..:...|.||||......
 Worm   128 AWVSET-------SNGFHAWWTSSIGDLLNSTEIKLDHKAFALC--LDAISIQNSVLLAVGTSKR 183

  Fly   174 TVSLWSEQVETAGEGDSLGRQFQRKHKLTGHEDWVRGLDFVVDGEDLLLASGSQDNFIRLWRIAP 238
            .|.|:.|..:.        :.|.|...:.||.||:..:.|..:.:.||:||..||.::|||.|.|
 Worm   184 FVELYGESADK--------KSFSRLISVAGHTDWIHSIAFNDNPDHLLVASAGQDTYVRLWAIEP 240

  Fly   239 RSKEQMQENRVDLHQLSHNDDEIKVEEKILQLGKEAWYAVSLESVLYGHEGWIYGVHWHKTPDQE 303
            .:.|:.:..|.|  ..:...||:.....:..:.... |..|..:|:.||:.|::...|  :.|..
 Worm   241 ETDEKSENIRED--SSTTPPDELTSSANLFSINYTP-YRCSSHAVMQGHDDWVHSTVW--SNDGR 300

  Fly   304 LRLLSASIDKTVIIWAPTEEGIWLEEVRVGEV-GGNSVGFYGGKF--------SGDGHS---IMA 356
            : ||:||.|||.|||... :.:|.::||:|.| ||.:.||:...|        ||:.::   :::
 Worm   301 V-LLTASSDKTCIIWKEI-DNLWRDDVRLGIVGGGQAAGFFAAVFSSSLDLKDSGEKNAENVVIS 363

  Fly   357 HSYQGGFHIWSQDPDRPQLWTPGVIVGGHYGEVRDLAWEHS----GAYLMTASADQTTRLHAPWL 417
            .||.||.|.|....::...||...:.|||.|||||:.|..|    ..:||:...|||||:.|
 Worm   364 SSYFGGLHCWKSTDEQKTFWTALPMTGGHVGEVRDVDWHRSDDGDSGFLMSVGQDQTTRVFA--- 425

  Fly   418 QDGANPTWHELARPQIHGYDMQALALLSRYKFASGAEEKIVRTFQAPANFIENFRHISGIENDDA 482
            ::|...::.|:||||:||:|||.|:.::...|.||||||:.|.|:||.:|:::...|||:..:.:
 Worm   426 KNGRQQSYVEIARPQVHGHDMQCLSFVNPSIFVSGAEEKVFRAFRAPKSFVKSLEAISGVPTEKS 490

  Fly   483 -GDVLLDSLPKGASVPSLGLSNKAVYKVDSEVESTSKTSKDEYPDNYFVPIALETPPQEETLMQN 546
             ||  .|....||.||:||||||.:  |:.|........:|.:   ...|:.|.:||.|:||.||
 Worm   491 FGD--SDLAEFGACVPALGLSNKPM--VEGETVDGEHWEEDAF---RAAPVVLTSPPTEDTLQQN 548

  Fly   547 TLWPELQKLYGHGYEIFALAATADGSLLASTCKASNAEHAQIILWNPSNWKQIQKLSGHQLTVTQ 611
            |||||..||||||||::|:.|...|::||:.||:|:.||:.::||:.|||.:..::.||||||||
 Worm   549 TLWPEQHKLYGHGYEVYAVTANPTGNVLATACKSSHVEHSVVMLWSTSNWSKKSEIIGHQLTVTQ 613

  Fly   612 LSFSPDSRYLLSVSRDRRWCLYERQDSSV---SYQLVASTDKSNGVHTRIIWSCDWSHDGQFFVT 673
            ::::|....||:|||||...||..::..|   .|..|.::.|.   ||||||:|||. |.:.|||
 Worm   614 IAWNPSGTRLLTVSRDRTAKLYTEKNGEVDGFDYDCVWTSGKQ---HTRIIWACDWI-DDEHFVT 674

  Fly   674 SSRDGKVVVWKKEEDCKESSLNGWQANGVLELKNESITAVAFSNSYLSGTDDTYILALGTETGLI 738
            :|||.||:||      .||:  |..|.......:|.:||:|      :.:.|  ::..|.:||.:
 Worm   675 ASRDQKVIVW------AESA--GQTAPKATVKLDEPVTAIA------AVSKD--VIVAGLQTGEL 723

  Fly   739 KIYQFVRGAWKLLSDLNKSQAHHL----TVRRLQF-RPGKQLQLASCGEDHLVRIYDI 791
            .:.:|....   |..:.|..|:.:    .|.||:| :.|::|.:|:  .|..:||:::
 Worm   724 IVLRFDSEG---LHVIEKIGANRIPIDSAVLRLRFSKNGRKLAVAT--TDAKLRIFNV 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Elp2	NP_610600.1	WD40 repeat	18..55	CDD:293791	6/36 (17%)
		WD40	50..412	CDD:475233	113/396 (29%)
		WD40 repeat	104..145	CDD:293791	9/40 (23%)
		WD40 repeat	150..202	CDD:293791	12/51 (24%)
		WD40 repeat	209..281	CDD:293791	19/71 (27%)
		WD40 repeat	291..331	CDD:293791	13/39 (33%)
		WD40 repeat	337..382	CDD:293791	14/55 (25%)
		WD40 repeat	389..412	CDD:293791	11/26 (42%)
		WD40	<548..792	CDD:441893	95/252 (38%)
		WD40 repeat	563..604	CDD:293791	15/40 (38%)
		WD40 repeat	609..652	CDD:293791	17/45 (38%)
		WD40 repeat	660..695	CDD:293791	17/34 (50%)
		WD40 repeat	702..758	CDD:293791	11/55 (20%)
		WD40 repeat	764..791	CDD:293791	10/27 (37%)
elpc-2	NP_499648.3	WD40 repeat	19..53	CDD:293791	6/35 (17%)
		WD40 repeat	64..106	CDD:293791	9/41 (22%)
		WD40	<80..314	CDD:441893	70/257 (27%)
		WD40 repeat	163..205	CDD:293791	12/51 (24%)
		WD40	<199..635	CDD:441893	174/452 (38%)
		WD40 repeat	210..250	CDD:293791	13/39 (33%)
		WD40 repeat	290..330	CDD:293791	16/43 (37%)
		WD40 repeat	338..389	CDD:293791	12/50 (24%)
		WD40 repeat	396..424	CDD:293791	12/27 (44%)
		WD40	<528..>777	CDD:441893	105/277 (38%)
		WD40 repeat	565..606	CDD:293791	15/40 (38%)
		WD40 repeat	611..654	CDD:293791	16/42 (38%)
		WD40 repeat	694..729	CDD:293791	8/42 (19%)
		WD40 repeat	750..776	CDD:293791	10/27 (37%)