DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and Smap1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_001344324.1	Gene:	Smap1 / 98366	MGIID:	2138261	Length:	467	Species:	Mus musculus

Alignment Length:	446	Identity:	107/446 - (23%)
Similarity:	163/446 - (36%)	Gaps:	112/446 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 SKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVL 99
            ||:.|.:   ..:.|.||.|..|.|||.|.|:.:|..|..:||:||.|||.|||:....|.|..:
Mouse    22 SKLLREE---DNKYCADCEAKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTPEQI 83

  Fly   100 NFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKH--------- 155
            ..:..:....|..::|.:|.:            .:|:|....|:    ..||:.|:
Mouse    84 QCMQDMGNTKARLLYEANLPE------------NFRRPQTDQAV----EFFIRDKYEKKKYYDKN 132

  Fly   156 ----VNLT--------FVLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGAD 208
                .|::        .|..||||...|.|.    ||:|..::.....|....|...:.|.....
Mouse   133 AIAITNISSSDAPLQPLVSSPSLQAAVDKNK----LEKEKEKKKDEKKREKEPEKPAKPLTTEKL 193

  Fly   209 PNYYHEDKLSTPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAM 273
            |. ..|.:|......:.|......|::|        .|||    |.|....|.:...|..|.|.:
Mouse   194 PK-KEEQQLEPKKSTSPKNAAEPTIDLL--------GLDG----PAEAPVTNGNPATAPALSDDL 245

  Fly   274 YDVTDRIITFLGGKKPDHASGRHMIIPDANG-------ADISEQLKIARGKLQLVPNKMFEELVM 331
             |:...:|:     .|..|:    ::|.|.|       |.:|   .:..|.|.|...:..:.
Mouse   246 -DIFGPMIS-----NPLPAA----VMPPAQGTASVPAPATLS---TVTSGDLDLFTEQTTKS--- 294

  Fly   332 DLYDEVDRREC--EAIWSTSTLNADHAT--VPFLPAN-PFLS--ATRNQGRQKLARFNRAEFTGL 389
               :||.:::.  ::|.|.....|..:|  |...|.| ||.|  .|..||           |..:
Mouse   295 ---EEVAKKQLSKDSILSLYGTGAQQSTPGVFMGPTNIPFTSQAPTAFQG-----------FPSM 345

  Fly   390 LTDV-----LVDAMRRQNMANL--RPMDAPVAGHQSLQSLPYANNSMLLGSFEQGG 438
            ...|     |:..|..||...:  .||.....|:.....:|...|  ::|  .|||
Mouse   346 GVPVPAAPGLIGNMMGQNTGMMVGMPMHNGFMGNAQTGVMPLPQN--VVG--PQGG 397

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	35/136 (26%)
		Ank_2	187..279	CDD:289560	19/91 (21%)
		ANK	<187..270	CDD:238125	16/82 (20%)
		ANK repeat	187..213	CDD:293786	4/25 (16%)
		ANK repeat	215..247	CDD:293786	4/31 (13%)
		ANK repeat	249..279	CDD:293786	7/29 (24%)
		GIT_SHD	314..342	CDD:285690	5/27 (19%)
		GIT	374..404	CDD:128828	7/34 (21%)
		GIT1_C	609..727	CDD:289013
Smap1	NP_001344324.1	ArfGap	20..120	CDD:307528	34/116 (29%)
Smap1	NP_001344324.1	Med15	<343..>451	CDD:312941	14/59 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900