DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and ACAP1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_055531.1	Gene:	ACAP1 / 9744	HGNCID:	16467	Length:	740	Species:	Homo sapiens

Alignment Length:	346	Identity:	89/346 - (25%)
Similarity:	129/346 - (37%)	Gaps:	71/346 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 RSKMPRGKSRLQTEV--------CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLR 90
            |.:.|.|...:..:|        |.||....|.|||||.|:.||..|..:|||||.|.|.|:||.
Human   397 RGREPGGVGHVVAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGIHRSLGVHFSKVRSLT 461

  Fly    91 QGNWEPSVLNFVNSLNAHGANSVWEHHL---------------------------------LDGS 122
            ..:|||.::..:..|.....|.::|..:                                 |...
Human   462 LDSWEPELVKLMCELGNVIINQIYEARVEAMAVKKPGPSCSRQEKEAWIHAKYVEKKFLTKLPEI 526

  Fly   123 TNSTGGKHVPRWRKPT-PKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSAGCLEQELSRQ 186
            ....||:..||.:.|. ||.::.|.......          ||....:|.|:...|.|      .
Human   527 RGRRGGRGRPRGQPPVPPKPSIRPRPGSLRS----------KPEPPSEDLGSLHPGAL------L 575

  Fly   187 LHASVRTSNLETSLRFLVQGADPNYYH--EDKLSTPLHMAAKFGQASQIEMLLIYGADVNALDGN 249
            ..||....:|.|....|..|||.|:.:  :|. :|||..|.........|.||..||:||..|..
Human   576 FRASGHPPSLPTMADALAHGADVNWVNGGQDN-ATPLIQATAANSLLACEFLLQNGANVNQADSA 639

  Fly   250 GMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPDHASGRHMIIPDANGADISEQLKIA 314
            |..||..|....|..:|...|....|        ||.:..:......:.:..|| |||...|::|
Human   640 GRGPLHHATILGHTGLACLFLKRGAD--------LGARDSEGRDPLTIAMETAN-ADIVTLLRLA 695

  Fly   315 R-GKLQLVPNKMFEELVMDLY 334
            : .:.:....:..:|..:|::
Human   696 KMREAEAAQGQAGDETYLDIF 716

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	39/157 (25%)
		Ank_2	187..279	CDD:289560	30/93 (32%)
		ANK	<187..270	CDD:238125	28/84 (33%)
		ANK repeat	187..213	CDD:293786	9/25 (36%)
		ANK repeat	215..247	CDD:293786	12/31 (39%)
		ANK repeat	249..279	CDD:293786	8/29 (28%)
		GIT_SHD	314..342	CDD:285690	3/22 (14%)
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
ACAP1	NP_055531.1	Required for formation of endosomal tubules when overexpressed with PIP5K1C	1..382
		BAR	18..217	CDD:299863
		PH	266..360	CDD:278594
		PH_ACAP	268..364	CDD:270070
		Required for interaction with GULP1	405..740		86/338 (25%)
		ArfGap	406..519	CDD:279720	30/112 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..581		16/71 (23%)
		Prevents interaction with ITGB1 when S-554 is not phosphorylated	525..566		10/50 (20%)
		ANK	<592..692	CDD:238125	33/109 (30%)
		ANK repeat	606..637	CDD:293786	12/31 (39%)
		Ank_5	626..680	CDD:290568	17/61 (28%)
		ANK repeat	639..670	CDD:293786	10/38 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810