DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and SPA2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_013079.1	Gene:	SPA2 / 850639	SGDID:	S000003944	Length:	1466	Species:	Saccharomyces cerevisiae

Alignment Length:	460	Identity:	104/460 - (22%)
Similarity:	172/460 - (37%)	Gaps:	78/460 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   308 SEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIWSTSTLNADHATVPFLPANPFLSATRN 372
            |.:.:.||.||..:.:..|.||..|:.||:.||          :..|.....:|.........||
Yeast    38 STRAQKARAKLLKLSSSQFYELSTDVSDELQRR----------IGEDANQPDYLLPKANFHMKRN 92

  Fly   373 QGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANL----RPMDAPVAGHQSLQSLPYANNSMLLGS 433
            |.|||||..::..|..||.|:|.:..||....:|    .|:..|:....|..|...|..|....|
Yeast    93 QARQKLANLSQTRFNDLLDDILFEIKRRGFDKDLDAPRPPLPQPMKQEVSKDSDDTARTSTNSSS 157

  Fly   434 FEQGGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEI 498
            ..|..  ||:|....:..|..:..|::......:|  |...|      ||.|..:..:::.|...
Yeast   158 VTQVA--PNVSVQPSLVIPKMASIDWSSEEEEEEQ--VKEKP------NEPEGKQTSMDEKKEAK 212

  Fly   499 NQLKNVV--------QMLSSENTQLKSKFSSASNN--SVYDEP-LRIDLSLSSPDTEHEPLSLPE 552
            ..|..:|        |:|:.:.|.:....::...|  .|.|.| :::|..:   |.|..|..|..
Yeast   213 PALNPIVTDSDLPDSQVLARDITSMARTPTTTHKNYWDVNDSPIIKVDKDI---DNEKGPEQLKS 274

  Fly   553 GGTANGESGSSNDSSNQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEE---- 613
            ......|:.:.| |..:..:|....: ...|...:...|..:.:.||  :...:.|...||
Yeast   275 PEVQRAENNNPN-SEMEDKVKELTDL-NSDLHLQIEDLNAKLASLTS--EKEKEKKEEKEEKEKE 335

  Fly   614 --VKVRSDLVTRRLKELIRAMQPV------PEDQKQSIAP----------HGELIRSAVTD-LIA 659
              :|:...:.....|||:.....:      .|:.||.|:.          |.:|   .:|| .|:
Yeast   336 KNLKINYTIDESFQKELLSLNSQIGELSIENENLKQKISEFELHQKKNDNHNDL---KITDGFIS 397

  Fly   660 LYANLPPNASDPSRETLKLLTRQNILIQHECENLQKAIEADDKQAIQKNTLEVRDCAFHIASAIK 724
            .|     :::|.......:|...|::||....  ..|:...|..||..   ::.:..|.|.|.:.
Yeast   398 KY-----SSADGLIPAQYILNANNLIIQFTTR--LSAVPIGDSTAISH---QIGEELFQILSQLS 452

  Fly   725 TLVLQ 729
            .|:.|
Yeast   453 NLISQ 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720
		Ank_2	187..279	CDD:289560
		ANK	<187..270	CDD:238125
		ANK repeat	187..213	CDD:293786
		ANK repeat	215..247	CDD:293786
		ANK repeat	249..279	CDD:293786
		GIT_SHD	314..342	CDD:285690	12/27 (44%)
		GIT	374..404	CDD:128828	12/29 (41%)
		GIT1_C	609..727	CDD:289013	28/140 (20%)
SPA2	NP_013079.1	GIT_SHD	44..71	CDD:400702	12/36 (33%)
		GIT_SHD	94..122	CDD:400702	12/27 (44%)
		DUF4573	876..1042	CDD:405774
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3377
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950