DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and git2a

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_005165241.1	Gene:	git2a / 793882	ZFINID:	ZDB-GENE-060526-267	Length:	804	Species:	Danio rerio

Alignment Length:	853	Identity:	296/853 - (34%)
Similarity:	411/853 - (48%)	Gaps:	214/853 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 PTISTRSKMPRGKSRLQ-TEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQG 92
            ||: |.::|.:   ||: :|||.||...||.|||:|||:|:|.:|||||||||||.|.|:.|...
Zfish     4 PTL-TETRMSK---RLRNSEVCADCSTSDPRWASVNRGVLICDECCSVHRSLGRHNSQVRHLSNT 64

  Fly    93 NWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVN 157
            :|.|:.|..|.:|..:|||::|||.|||.|:..:..      |||..:|.|||.|:||||||:..
Zfish    65 SWPPTQLQMVQTLYNNGANAIWEHTLLDPSSIMSSK------RKPNHQDKLHPNKADFIKAKYQM 123

  Fly   158 LTFVLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLH 222
            |.:|.:...:|||....:      :||:|||:||||.||||.||.|..||..||:|.:|.:||||
Zfish   124 LAYVHRLPCRDDDSTAAA------DLSKQLHSSVRTGNLETCLRLLSLGAQANYFHPEKGNTPLH 182

  Fly   223 MAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGK 287
            :|||.||..|.|:|.:||||..|.|.:|.||:..||...|..:|:||::..|::|||:..:|.|:
Zfish   183 IAAKAGQVCQAELLCVYGADPGAPDSSGKTPINYARQAGHQDLADRLVEIQYELTDRLAFYLCGR 247

  Fly   288 KPDHASGRHMIIP---DAN-GADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIW-- 346
            ||||.||:|.|||   |.| ..:::|..|.|:.|||.:.:.:||||.||:||||||||.:|:|
Zfish   248 KPDHKSGQHFIIPQMADRNVSVELTEFAKAAKRKLQSLSDHLFEELAMDVYDEVDRRETDAVWLA 312

  Fly   347 --STSTLNADHATVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPM 409
              :.|||..:...|||||.||..|:|||||||||||||..||..|:.|:|.||.|||
Zfish   313 TQNHSTLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQ-------- 369

  Fly   410 DAPVAGHQSLQSLPYANNSMLLGSFEQGG--HDPNLSD-DEPIYDPVASDDDY------------ 459
                  |.:....|..|..:.   |:.||  |.....: |:|.||.||||:|.
Zfish   370 ------HGNPVPSPKDNVDVF---FKSGGSRHGSESQEIDQPDYDSVASDEDTDTDLRMGKADRT 425

  Fly   460 ------APVPPMAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQMLSSENTQLKSK 518
                  ....|::.|..:......:.|..:::.|.|..::...|:..::..:|.|.|||:.|:.:
Zfish   426 KSLDSDLSDGPVSVQEFLEVKNALSASEAKIQELMKANSNLNEELRLMQKKLQSLQSENSSLRRQ 490

  Fly   519 FSSASNNSVYDEPLRIDLSLSSPDTEHEPLSLPEGGTANGESGSSNDSSNQSTIK--------RP 575
            .|:   ...|..|       ..||  |...|.|        |..|:.||:.|.:|        ||
Zfish   491 VSA---QQPYQAP-------GGPD--HPNPSSP--------SSCSSSSSSSSALKRHLSARASRP 535

  Fly   576 ASMYE--RRLVPNVAKGNT-----------------------------DIRNTTSMYQMAGDGKP 609
            .||||  ..|.|.:.||.|                             |..||.:...:  |...
Zfish   536 MSMYETGSGLKPFLPKGETPYPEETFPTLQPFPAYASKFDKQSSVSDGDYDNTVNESDL--DDSG 598

  Fly   610 FGEEVKVRS----------------------------------DLVTRRLKELIRAMQ-----PV 635
            ||...::||                                  :.:|:.::||:||.|     ..
Zfish   599 FGRRCRLRSSGWMGESGSIPELEDHECELDPSLPSTEDVIRKTEQITKNIQELLRAAQENKHESA 663

  Fly   636 PEDQKQSI------------------------------APH--------------GELIRSAVTD 656
            |.:|::|:                              |||              .|.|..||.:
Zfish   664 PCEQRESVRRLRHSLGCFSTLVPWADKPPSPMQPLGLRAPHPANPNNPASCFVPCAERIHVAVNE 728

  Fly   657 LIALYANLPPNASDPSRETLKLLTRQNILIQHECENLQKAIEADDKQA--IQKNTLEVRDCAFHI 719
            :.||:...|  .|:..|.:|:|||.....:|.||   :||...:..||  :|..|.:|..||:.|
Zfish   729 MAALFPKRP--RSETVRNSLRLLTSSANRLQTEC---KKASPLESSQASDMQLVTQQVIQCAYDI 788

  Fly   720 ASAIKTLV 727
            |.|.|.||
Zfish   789 AKAAKQLV 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	59/115 (51%)
		Ank_2	187..279	CDD:289560	48/91 (53%)
		ANK	<187..270	CDD:238125	45/82 (55%)
		ANK repeat	187..213	CDD:293786	17/25 (68%)
		ANK repeat	215..247	CDD:293786	18/31 (58%)
		ANK repeat	249..279	CDD:293786	11/29 (38%)
		GIT_SHD	314..342	CDD:285690	17/27 (63%)
		GIT	374..404	CDD:128828	19/29 (66%)
		GIT1_C	609..727	CDD:289013	45/202 (22%)
git2a	XP_005165241.1	ArfGap	12..134	CDD:214518	62/130 (48%)
		Ank_2	147..239	CDD:289560	48/91 (53%)
		ANK	<147..230	CDD:238125	45/82 (55%)
		ANK repeat	147..175	CDD:293786	18/27 (67%)
		ANK repeat	177..207	CDD:293786	17/29 (59%)
		GIT_SHD	278..306	CDD:285690	17/27 (63%)
		GIT_SHD	342..369	CDD:285690	17/26 (65%)
		GIT_CC	426..490	CDD:293167	12/63 (19%)
		GIT1_C	632..798	CDD:289013	43/170 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	148	1.000	Domainoid score	I4416
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41336
Inparanoid	1	1.050	414	1.000	Inparanoid score	I1809
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D175450at33208
OrthoFinder	1	1.000	-	-		FOG0003139
OrthoInspector	1	1.000	-	-		otm25285
orthoMCL	1	0.900	-	-		OOG6_104890
Panther	1	1.100	-	-	O	PTHR46097
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3769
SonicParanoid	1	1.000	-	-		X2107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860