DRSC/TRiP Functional Genomics Resources

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Protein Alignment Git and Appl1

DIOPT Version :9

Sequence 1:NP_610599.3 Gene:Git / 36122 FlyBaseID:FBgn0033539 Length:731 Species:Drosophila melanogaster
Sequence 2:NP_660256.1 Gene:Appl1 / 72993 MGIID:1920243 Length:707 Species:Mus musculus


Alignment Length:640 Identity:120/640 - (18%)
Similarity:182/640 - (28%) Gaps:277/640 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   150 FIKAKHVNLTFVLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHE 214
            |.|....||...|:..|       .:.|...|.:.|::...|.|  ::.::..|...:||.|..:
Mouse   210 FFKMGSENLNGQLEEFL-------ANIGTSVQNVRREMDGDVET--MQQTIEDLEVASDPLYLPD 265

  Fly   215 -DKLSTPL--HMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDV 276
             |....|:  ::..|.|..:                           |.|...:.....|..:..
Mouse   266 PDPTKFPINRNLTRKAGYLN---------------------------ARNKTGLVSSTWDRQFYF 303

  Fly   277 TDRIITFLGGKKPDHASGRHMIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDL-------Y 334
            |.      ||.....|.|                 .:|.|            |.||:       .
Mouse   304 TQ------GGNLMSQARG-----------------DVAGG------------LAMDIDNCSVMAV 333

  Fly   335 DEVDRRECEAIWS-----TSTLNA----DH----ATVPFLPANPFLSATRNQGRQKLARFNRAEF 386
            |..|||.|..|.|     :|.|.|    ||    .|:..:....:||   ....:..||.|::  
Mouse   334 DCEDRRYCFQITSFDGKKSSILQAESKKDHEEWICTINNISKQIYLS---ENPEETAARVNQS-- 393

  Fly   387 TGLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQSLPYANNSMLLGSFEQGGHDPNLSDDEPIYD 451
              .|..|......:|...:|||      |.||.                                
Mouse   394 --ALEAVTPSPSFQQRHESLRP------GGQSR-------------------------------- 418

  Fly   452 PVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQMLSSENTQLK 516
                       ||.|         |:::|.:                         |.||:|.| 
Mouse   419 -----------PPTA---------RTSSSGS-------------------------LGSESTNL- 437

  Fly   517 SKFSSASNNSVY--DEPLRIDLSLSSPDTEHEP---LSLPEGGTAN---GESGSSNDSSNQSTIK 573
               ::.|.:|:.  |.|::.|  :.||..|.:|   .:..:||...   ||||.|..|..:.:|.
Mouse   438 ---AALSLDSLVAPDTPIQFD--IISPVCEDQPGQAKAFGQGGRRTNPFGESGGSTKSETEDSIL 497

  Fly   574 RPASMYERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEVKVRSDLVTRRLKELIRAMQ----- 633
            ....:               :|...|| ::..|..|......:|..|..|.:..:.|..:     
Mouse   498 HQLFI---------------VRFLGSM-EVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLV 546

  Fly   634 -------------------PVP--------------------------EDQKQSIA------PHG 647
                               |:|                          |....|:.      ..|
Mouse   547 TCDCLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSGGRSESNLSSVCYIFESNNEG 611

  Fly   648 ELIRSAV--TDLIALYANLPPNASDPSRETLKLLTRQNILIQHECENLQKAIEAD 700
            |.|..:|  ...|||:|.|...||:..:|..::..:|    |.|... ||.||.|
Mouse   612 EKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQ----QKELSK-QKQIEKD 661

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GitNP_610599.3 ArfGap 48..164 CDD:279720 5/13 (38%)
Ank_2 187..279 CDD:289560 14/94 (15%)
ANK <187..270 CDD:238125 12/85 (14%)
ANK repeat 187..213 CDD:293786 6/25 (24%)
ANK repeat 215..247 CDD:293786 4/33 (12%)
ANK repeat 249..279 CDD:293786 4/29 (14%)
GIT_SHD 314..342 CDD:285690 9/34 (26%)
GIT 374..404 CDD:128828 6/29 (21%)
GIT1_C 609..727 CDD:289013 29/150 (19%)
Appl1NP_660256.1 Required for RAB5A binding. /evidence=ECO:0000250 1..428 63/353 (18%)
BAR_APPL1 20..234 CDD:153315 7/30 (23%)
BAR-PH_APPL 252..376 CDD:270067 34/185 (18%)
PH 280..375 CDD:278594 28/156 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 397..433 14/118 (12%)
F&H. /evidence=ECO:0000250 403..414 4/16 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 466..490 7/23 (30%)
PTB_APPL 489..624 CDD:269980 19/150 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 636..707 9/31 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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