Protein Alignment Git and Arfgap3

DIOPT Version :9

• Sequence 1: NP_610599.3
• Gene: Git / 36122
• FlyBaseID: FBgn0033539
• Length: 731
• Species: Drosophila melanogaster
• Sequence 2: NP_001344685.1
• Gene: Arfgap3 / 66251
• MGIID: 1913501
• Length: 525
• Species: Mus musculus
• Alignment Length: 717
• Identity: 143/717 - (19%)
• Similarity: 220/717 - (30%)
• Gaps: 297/717 - (41%)

  Fly    25 DPATPTISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSL 89
            ||:...|....|  |.:|....:||.||||.:||||||:.|:.||.||...|||||.|:|.::|.
Mouse     3 DPSKQDILAIFK--RLRSVPTNKVCFDCGAKNPSWASISYGVFLCIDCSGSHRSLGVHLSFIRST 65

  Fly    90 R-QGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPR-------------------- 133
            . ..||....|..:.......|:|.:..|  ..:|..|..|:..|
Mouse    66 ELDSNWSWFQLRCMQVGGNSNASSFFHQH--GCATKDTNAKYNSRAAQLYREKIKTLATQATRRH 128

  Fly   134 ----WR--------KPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSAGCLEQELSRQ 186
                |.        .|.||:      .||. |.|.:|                       |:|..
Mouse   129 GTDLWLDSCAAPPVSPPPKE------EDFF-ASHASL-----------------------EVSGA 163

  Fly   187 LHASVRTSN-------LETSLRFLVQGADPNYYHEDKLSTPLHMAAKFGQASQIEMLLIYGADVN 244
            :.||.:..:       |||                    ||.......||...:|.|
Mouse   164 MQASAQPESASSTPWGLET--------------------TPEKHEGGPGQGPSVEGL-------- 200

  Fly   245 ALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPDHASGRHMIIPDANGADISE 309
                  .||.:.|.|...:.|.                    |||:.|               .:
Mouse   201 ------NTPGKAAPAEVSSIIK--------------------KKPNQA---------------KK 224

  Fly   310 QLKIARGKL--QLVPNKMFEELVMDLYDEVDRRECEAIWSTSTLNADHATVPFLPANPFLSATRN 372
            .|...:|.|  |.:.|..|.|:         .::.:|:                        .:.
Mouse   225 GLGAKKGSLGAQKLTNTSFTEI---------EKQAQAV------------------------DKR 256

  Fly   373 QGRQKLARFNRAEFTGLLTDVLVDAMR--------------RQNMANLRPMDAPVAGHQSLQSLP 423
            :.::.|||....|      :.:|.::|              |.|::..:.::|...|
Mouse   257 KEQEDLARGAPKE------ESIVSSLRLAYKDLEISRKKDERLNLSGQKKVEAERLG-------- 307

  Fly   424 YANNSMLLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLR 488
                 |..||...|           |...|.||          .|.|          ..|..||.
Mouse   308 -----MGFGSCRSG-----------ISHSVTSD----------MQTI----------EQESPTLA 336

  Fly   489 KQLNDYKSEINQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLRI-DLSLSSPDTEHEPLSLPE 552
            |....|:.:...     ...||     .||:|..|::..:|:|:.: ..|.||.|         :
Mouse   337 KPRRKYQEDPED-----SYFSS-----SSKWSEQSSSRYFDDPMELRSSSFSSWD---------D 382

  Fly   553 GGTANGESGSSNDSS----NQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEE 613
            |..:..:..||.|..    :..:..||::..:....|        |.:|....:..|:.|....:
Mouse   383 GADSYWKKDSSRDPEPAMRSTGSSDRPSARRKPEYEP--------IGSTDEAQKKFGNVKAISSD 439

  Fly   614 ----VKVRSDLVTR-RLKEL-----IRAMQPVPEDQKQSIAPHGELIRSAVTDLIALYANLPPNA 668
                ::.::|..|| ||:.|     |.:.....|.:||:...:.             .:|:.|||
Mouse   440 MYFGIQAQTDFETRARLERLSTSSSISSADLFDEQRKQTAGNYN-------------LSNVLPNA 491

  Fly   669 SD 670
            .|
Mouse   492 PD 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	44/148 (30%)
		Ank_2	187..279	CDD:289560	16/98 (16%)
		ANK	<187..270	CDD:238125	16/89 (18%)
		ANK repeat	187..213	CDD:293786	5/32 (16%)
		ANK repeat	215..247	CDD:293786	6/31 (19%)
		ANK repeat	249..279	CDD:293786	5/29 (17%)
		GIT_SHD	314..342	CDD:285690	6/29 (21%)
		GIT	374..404	CDD:128828	8/43 (19%)
		GIT1_C	609..727	CDD:289013	15/72 (21%)
Arfgap3	NP_001344685.1	ArfGap	13..116	CDD:214518	38/106 (36%)
		CDC27	<134..>292	CDD:312868	44/295 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..206		13/77 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	249..271		5/51 (10%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900