DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and arfgap2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_005159305.1	Gene:	arfgap2 / 641490	ZFINID:	ZDB-GENE-051120-177	Length:	551	Species:	Danio rerio

Alignment Length:	634	Identity:	124/634 - (19%)
Similarity:	200/634 - (31%)	Gaps:	231/634 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SDPATPTISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKS 88
            |:|....|.|..|  |.:|....:.|.||.|.:||||||:.|:.||.||..:|||||.|:|.::|
Zfish     3 SEPNKTEIHTIFK--RLRSIPTNKACFDCAAKNPSWASISYGVFLCIDCSGIHRSLGVHLSFIRS 65

  Fly    89 LR-QGNWEPSVL---------NFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPR---------- 133
            .. ..||....|         |.:.....||.           :||.|..|:..|
Zfish    66 TELDSNWNWFQLRCMQVGGNANAMGFFRQHGC-----------TTNDTNAKYNSRAAQMYREKIR 119

  Fly   134 --------------W------RKPTPKDALHPTKSDFIKAKHVNLTF---VLKPSLQDDDDGNGS 175
                          |      .:|:|   :...::||.. :|.....   :..|||.|.   ||:
Zfish   120 QLANAALSKYGTDLWIDSSSCAQPSP---VEKRETDFFD-EHTQPAISWDMASPSLTDQ---NGA 177

  Fly   176 AGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAAKFGQASQIEMLLIYG 240
                 :.::.|| |.....|.||          ||...|:                        |
Zfish   178 -----ENVNPQL-AQSNPKNSET----------PNTQPEE------------------------G 202

  Fly   241 ADVNALDGNGMTPLELARANNHNTIAERLLDAM----------YDVTDRIITFLGGKKPDHASGR 295
            ..:..|..:....:|               |:|          .||...||    |||...|:.:
Zfish   203 PSIEGLSTSPKATIE---------------DSMRLTSEEPQSPKDVKPSII----GKKKPVAAKK 248

  Fly   296 HMIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIWSTSTLNADHATVPF 360
            .:......||             |.|.:|.|.|:..........||.:|
Zfish   249 GLGAKKGLGA-------------QKVSSKSFSEVEKQAQVAEKMREEQA---------------- 284

  Fly   361 LPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPVAG---------- 415
                   :..:.|..:.:....|..:..|..|..::..:.||:...:...|...|
Zfish   285 -------AEAKKQADESIVASMRLAYKELEIDRKMEEKKMQNLEGKKKEQAERLGMGFGNRSAVS 342

  Fly   416 HQSL-------QSLPY---ANNSMLLGSFEQGGHDPNLSDDEPIY--DPVASDDDYAPVPPMAQQ 468
            |..:       |..|.   :::...|..||    :|..:...|.|  :|..|.|.:..
Zfish   343 HSVMAEMQVIEQETPVGVKSSSRSKLDMFE----EPGFASGPPKYKDNPFTSGDSFGS------- 396

  Fly   469 AIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQMLS-----------SENTQLKSKFSSA 522
               .......:|.:.....:::..|.:..|:.::.:.:.|.           ||:::.:.||::|
Zfish   397 ---RWDNDGGSSFSSWALEKEEPKDSEVTISSIQPIGERLPSRRKPEVSVPVSESSEARQKFANA 458

  Fly   523 -----------SNNSVYDEPLRID-----LSLSSPDTEHEPLSLPEGGT 555
                       .:|..|:...|::     .|:||.|...:....|.|.|
Zfish   459 KAISSDMFFGRESNPEYEAKTRLEGMSGSTSISSADLFGDGSVRPSGST 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	40/158 (25%)
		Ank_2	187..279	CDD:289560	15/101 (15%)
		ANK	<187..270	CDD:238125	11/82 (13%)
		ANK repeat	187..213	CDD:293786	7/25 (28%)
		ANK repeat	215..247	CDD:293786	1/31 (3%)
		ANK repeat	249..279	CDD:293786	5/39 (13%)
		GIT_SHD	314..342	CDD:285690	6/27 (22%)
		GIT	374..404	CDD:128828	5/29 (17%)
		GIT1_C	609..727	CDD:289013
arfgap2	XP_005159305.1	PLN03114	1..498	CDD:178661	121/623 (19%)
		ArfGap	13..117	CDD:279720	37/116 (32%)
		TMF_DNA_bd	270..331	CDD:289127	10/83 (12%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900