DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and Acap2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_017453554.1	Gene:	Acap2 / 619382	RGDID:	1562939	Length:	816	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	121/458 - (26%)
Similarity:	158/458 - (34%)	Gaps:	162/458 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSIIEAHRKLFIAPPDLD-HSDPATPTI----STRSKMPRGKSRLQ-------TEVCGDCGAGDP 57
            :||..|:|:.......|| .|.|:|.::    .::.|:.:|:|.||       ...|.|||..||
  Rat   369 TSIATAYREKGDESEKLDKKSSPSTGSLDSGSESKEKLLKGESALQRVQCIPGNTSCCDCGLADP 433

  Fly    58 SWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGS 122
            .|||||.||.||.:|..:|||||.|.|.|:||....|||.:|..:..|.....|.|:|..|
  Rat   434 RWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYEAKL---- 494

  Fly   123 TNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFV------LKPSLQD------------- 168
             ...|.|      ||.|  .....|..:|:||:|...||      |.||.|:
  Rat   495 -EKMGVK------KPQP--GQRQEKEAYIRAKYVERKFVDKYSTLLSPSEQEKRIISKSCEDQRL 550

  Fly   169 --------------------------------------------------------DDDGNG--- 174
                                                                    .|||..
  Rat   551 SHTRVSVHTPVAAVNSDEARRESLFCPDELDSLFSYFDTSSKLRSIKSNDSGIQQCSDDGRESLP 615

  Fly   175 ---SAGCL------EQELS-----------RQLHASVRTSNLETSLRFLVQGADPNYYHEDK-LS 218
               ||..|      .||.|           .||:.:....||......|..|||.|:.:.|: .:
  Rat   616 STVSANSLYEPEGERQESSVFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNWANSDENQA 680

  Fly   219 TPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITF 283
            |||..|...|.....|.||..||:||..|..|..||..|....|              |.::..|
  Rat   681 TPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGH--------------TGQVCLF 731

  Fly   284 LGGKKPDHASGRH-----MIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECE 343
            |......||:...     .|..:|..|||...|::||         |.||:          ||.|
  Rat   732 LKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLAR---------MNEEM----------RESE 777

  Fly   344 AIW 346
            .::
  Rat   778 GLY 780

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	48/121 (40%)
		Ank_2	187..279	CDD:289560	28/92 (30%)
		ANK	<187..270	CDD:238125	27/83 (33%)
		ANK repeat	187..213	CDD:293786	8/25 (32%)
		ANK repeat	215..247	CDD:293786	13/32 (41%)
		ANK repeat	249..279	CDD:293786	6/29 (21%)
		GIT_SHD	314..342	CDD:285690	6/27 (22%)
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
Acap2	XP_017453554.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810