DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and appl1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_021335332.1	Gene:	appl1 / 571540	ZFINID:	ZDB-GENE-081016-1	Length:	708	Species:	Danio rerio

Alignment Length:	724	Identity:	134/724 - (18%)
Similarity:	238/724 - (32%)	Gaps:	257/724 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAAK 226
            ::.:|:|........|..|::          .:.:.:....|.:.....|..:::||...|:.:|
Zfish     9 IEETLEDSPQTRSLLGVFEED----------AAAISSYFNQLFKAMQRIYDAQNELSAATHLTSK 63

  Fly   227 FGQASQIEMLLIYGADVNALDGNGMTPLELAR-----ANNHNTIAERLLDA-MYDVTD------R 279
            ..:..:.:...:.|.|    :....|..:.|:     ::.|..::.:|.|| |:.:|.      |
Zfish    64 LLKDYEKQRFPLGGDD----EVMSSTLQQFAKVIDELSSCHAVLSTQLADAMMFPITQFQERDLR 124

  Fly   280 IITFLGGKKPDHASGRHMIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEA 344
            .|..|        .....:..|.:.|.:....::::.|..   .|:..|::.|:|....::....
Zfish   125 EILIL--------KEVFQLASDDHDAAVHRYSRLSKRKEN---EKVKNEVMEDVYTSRKKQHETT 178

  Fly   345 IWSTSTLNADHATVPFLPANPFLSATRNQ------GRQKLARFNRAEFTGLLTDV--LVDAMRRQ 401
            :...::||............|.|...:.|      |.:.|.:    ::...||::  .|..:||:
Zfish   179 MHYFASLNMLQYKKKIALLEPLLGYMQAQISFFKLGSENLTQ----QWEDFLTNIGTSVQNVRRE 239

  Fly   402 NMANLRPMDAPVAGHQSLQSLPYA------------------------------NNSMLLGS--- 433
            ..::...|:      |::|.|..|                              |.:.|:.|
Zfish   240 MDSDAEAME------QTIQDLKEASDPLYMPDPDPNRIPVNRNLTRKAGYLNTRNKTGLVSSSWE 298

  Fly   434 ----FEQGGHDPNLSDDE--PIYDPVASDDDYAPVPPM---------------AQQAIVHTPPRS 477
                |.|||   ||....  .:...:..|.|...|..:               .::|.|    ..
Zfish   299 RQYFFTQGG---NLMSQSRGAVAGGLVMDIDNCSVMAVDCEDRRFCFQITAFDGKKAAV----LQ 356

  Fly   478 ANSHNEMETLRKQLND-----YKSE--------INQ--LKNVVQMLSSE--------NTQLKSKF 519
            |:|..:.|.....:|:     |.||        :||  |:.|....|.:        |||.|.|.
Zfish   357 ADSRKDCEEWIATINNISKRIYLSENPEEIAARVNQSALEAVTPSPSFQQRHESFRPNTQGKVKA 421

  Fly   520 S-SASNNSVYDE-PLRIDLSLSS---PDT------------EH--EPLSLPEGGTAN--GESGSS 563
            | |.|..||..| |....|||.|   |||            ||  :..|..:|...|  ||||.|
Zfish   422 SRSGSQCSVGSESPALSSLSLDSLVAPDTPIQFDIISPVSEEHTSQTKSSAQGRRTNPFGESGGS 486

  Fly   564 NDSSNQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEVKVRSDLVTRRLKEL 628
            ....::.:|     :::..:|..:  |:.:::.|.|                  ||::...::::
Zfish   487 QSEESEDSI-----LHQLFIVRFL--GSMEVKATES------------------SDVIYETMRQI 526

  Fly   629 I--RAMQPV-------------------PEDQKQSI----------APH---------------- 646
            :  ||:..:                   |:.|...:          |.|
Zfish   527 LAARAIHNIFRMTESHLLVTCECLKLIDPQTQVTRLRFPLSSVVLCASHQENKRLFGFVLQTAGG 591

  Fly   647 ------------------GELIRSAV--TDLIALYANLPPNASDPSRETLKLLTRQNILIQHECE 691
                              ||.|..::  ...|||::.:...||...||..|...:|    |.|..
Zfish   592 RADGQPVTVCYIFESNNDGEKICDSIGLAKQIALHSEMDRKASQKQRELDKAKEKQ----QEELH 652

  Fly   692 NLQKAIEAD 700
            . ||.||.|
Zfish   653 K-QKQIEKD 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	0/1 (0%)
		Ank_2	187..279	CDD:289560	16/103 (16%)
		ANK	<187..270	CDD:238125	11/87 (13%)
		ANK repeat	187..213	CDD:293786	2/25 (8%)
		ANK repeat	215..247	CDD:293786	6/31 (19%)
		ANK repeat	249..279	CDD:293786	8/41 (20%)
		GIT_SHD	314..342	CDD:285690	5/27 (19%)
		GIT	374..404	CDD:128828	7/31 (23%)
		GIT1_C	609..727	CDD:289013	27/159 (17%)
appl1	XP_021335332.1	BAR_APPL1	20..234	CDD:153315	37/242 (15%)
		BAR-PH_APPL	252..376	CDD:270067	21/130 (16%)
		PTB_APPL	488..623	CDD:269980	16/159 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900