DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and ADAP2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_024306599.1	Gene:	ADAP2 / 55803	HGNCID:	16487	Length:	403	Species:	Homo sapiens

Alignment Length:	492	Identity:	102/492 - (20%)
Similarity:	155/492 - (31%)	Gaps:	185/492 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSV 113
            |.||||.||.|||...||.:|.:||.|||:. ..||.|||:|...|:.|::.|:    .|..|.
Human    25 CADCGAADPDWASYKLGIFICLNCCGVHRNF-PDISRVKSVRLDFWDDSIVEFM----IHNGNL- 83

  Fly   114 WEHHLLDGSTNSTGGKHVPR-WRKPTPKDALHPTKSDFIKAKHVNLTFVLKP---SLQDDDDG-- 172
                    ...:.....||. :..|...|.| ..|..:|:||:....|:...   ||..:.:|
Human    84 --------RVKAKFEARVPAFYYIPQANDCL-VLKEQWIRAKYERREFMADGETISLPGNREGFL 139

  Fly   173 --NGSAGCLEQELSRQLHASVRTSNLETSLRFLV--QGADPN----------YYHEDKLSTPLHM 223
              .|...  .|.|.|:.....|    |..|::..  ||..|.          .:..:|:..|..:
Human   140 WKRGRDN--SQFLRRKFVLLAR----EGLLKYFTKEQGKSPKAVISIKDLNATFQTEKIGHPHGL 198

  Fly   224 AAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKK 288
            ...:.:......|.:|
Human   199 QITYRRDGHTRNLFVY------------------------------------------------- 214

  Fly   289 PDHASGRHMIIPDANGADISEQLKIARGKLQLVPNKM-FEELVMDLYDEVDRRECEAIWSTSTLN 352
              |.||:.::       |....|:.||  ||.:  || |.||
Human   215 --HESGKEIV-------DWFNALRAAR--LQYL--KMAFPEL----------------------- 243

  Fly   353 ADHATVPFLPAN----PFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPV 413
            .:...||||..|    .|:..|   |.::...|.:..|.       :|...|:.:....|:||
Human   244 PESELVPFLTRNYLKQGFMEKT---GPKQKEPFKKRWFA-------LDCHERRLLYYKNPLDA-- 296

  Fly   414 AGHQSLQSLPYANNSMLLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVPP-------------- 464
                      :....:.||:.|||            |:.      |..:|.
Human   297 ----------FEQGQVFLGNKEQG------------YEA------YEDLPKGIRGNRWKAGLTIV 333

  Fly   465 MAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQL 501
            ..::..|.|.|........:|:||..|:...:.:|:|
Human   334 TPERRFVLTCPSEKEQQEWLESLRGVLSSPLTPLNRL 370

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	39/115 (34%)
		Ank_2	187..279	CDD:289560	10/103 (10%)
		ANK	<187..270	CDD:238125	10/94 (11%)
		ANK repeat	187..213	CDD:293786	6/37 (16%)
		ANK repeat	215..247	CDD:293786	4/31 (13%)
		ANK repeat	249..279	CDD:293786	0/29 (0%)
		GIT_SHD	314..342	CDD:285690	9/28 (32%)
		GIT	374..404	CDD:128828	5/29 (17%)
		GIT1_C	609..727	CDD:289013
ADAP2	XP_024306599.1	ArfGap	8..126	CDD:307528	39/115 (34%)
		PH1_ADAP	133..241	CDD:270072	26/175 (15%)
		PH2_ADAP	255..362	CDD:241282	26/146 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810