DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and ARFGAP1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_011527203.1	Gene:	ARFGAP1 / 55738	HGNCID:	15852	Length:	416	Species:	Homo sapiens

Alignment Length:	474	Identity:	94/474 - (19%)
Similarity:	154/474 - (32%)	Gaps:	173/474 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 STRSKMPRGKSRLQTE--VCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNW 94
            |.|::....:.|:|.|  ||.:|||.:|.|.|:..||.:|.:|...||.||.|:|.|:|:....|
Human     3 SPRTRKVLKEVRVQDENNVCFECGAFNPQWVSVTYGIWICLECSGRHRGLGVHLSFVRSVTMDKW 67

  Fly    95 EPSVLNFVNSLNAHGAN-----------------SVWEHH--------------LLDGSTNSTGG 128
            :...|..:.:    |.|                 |:.|.:              |.:|...|...
Human    68 KDIELEKMKA----GGNAKFREFLESQEDYDPCWSLQEKYNSRAAALFRDKVVALAEGREWSLES 128

  Fly   129 KHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQD---DDDGNGSAGCLEQELSRQLHAS 190
            .....|..|.|:..  |:....:..:..::|.....:.:|   ||.|:
Human   129 SPAQNWTPPQPRTL--PSMVHRVSGQPQSVTASSDKAFEDWLNDDLGS----------------- 174

  Fly   191 VRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAAKFG-----QASQIEMLLIYGADVNALDGNG 250
                         .|||..|.|            ..||     |..:.:.|           .|.
Human   175 -------------YQGAQGNRY------------VGFGNTPPPQKKEDDFL-----------NNA 203

  Fly   251 MTPLELARANNHNTIAERLLDAMYDVTDRIIT-----FLGGK-KPDHASGRHMIIPDANGADISE 309
            |:.| .:..::..|.|.|...|..:...:..:     |.|.| :|:.||        ..|..::|
Human   204 MSSL-YSGWSSFTTGASRFASAAKEGATKFGSQASQKFWGHKQQPEPAS--------ELGHSLNE 259

  Fly   310 Q-LKIARGKLQLVPNKMFEEL---VMDLYDEVDRRECEAIWSTSTLNADHATVPFLPANPFLSAT 370
            . ||.|:.|::  ..|:|:::   |..|..:|                              ...
Human   260 NVLKPAQEKVK--EGKIFDDVSSGVSQLASKV------------------------------QGV 292

  Fly   371 RNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQS-LPYANNSMLLGSF 434
            .::|.:.:..|...:..|                   |:|:|..||....| |.:..||.:..||
Human   293 GSKGWRDVTTFFSGKAEG-------------------PLDSPSEGHSYQNSGLDHFQNSNIDQSF 338

  Fly   435 EQ--GGHDPNLSDDEPIYD 451
            .:  |..:|..:...|..|
Human   339 WETFGSAEPTKTRKSPSSD 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	34/146 (23%)
		Ank_2	187..279	CDD:289560	16/96 (17%)
		ANK	<187..270	CDD:238125	15/87 (17%)
		ANK repeat	187..213	CDD:293786	4/25 (16%)
		ANK repeat	215..247	CDD:293786	4/36 (11%)
		ANK repeat	249..279	CDD:293786	7/29 (24%)
		GIT_SHD	314..342	CDD:285690	7/30 (23%)
		GIT	374..404	CDD:128828	3/29 (10%)
		GIT1_C	609..727	CDD:289013
ARFGAP1	XP_011527203.1	ArfGap	7..114	CDD:279720	29/110 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900