DRSC/TRiP Functional Genomics Resources

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Protein Alignment Git and ASAP3

DIOPT Version :9

Sequence 1:NP_610599.3 Gene:Git / 36122 FlyBaseID:FBgn0033539 Length:731 Species:Drosophila melanogaster
Sequence 2:XP_011540057.1 Gene:ASAP3 / 55616 HGNCID:14987 Length:926 Species:Homo sapiens


Alignment Length:657 Identity:155/657 - (23%)
Similarity:230/657 - (35%) Gaps:223/657 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 EAHRKLFIAPPDLDHSDPAT---------PTISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINR 64
            ||....|:..|.   :.|.:         |...|:..:...|||.....|.||||.||:|.|.|.
Human   397 EALSSAFLGEPS---AGPGSWGSAGHDGEPHDLTKLLIAEVKSRPGNSQCCDCGAADPTWLSTNL 458

  Fly    65 GILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGK 129
            |:|.|..|..|||.||...|.::||......||.|....::.....|.|.|..|     .|.||.
Human   459 GVLTCIQCSGVHRELGVRFSRMQSLTLDLLGPSELLLALNMGNTSFNEVMEAQL-----PSHGGP 518

  Fly   130 HVPRWRKPTPKDALHPTKSDFIKAKHV----------------------NLTFVLKPSLQDDDDG 172
                  ||:.:..: .|:.|:|.||:|                      :|..||:......|.|
Human   519 ------KPSAESDM-GTRRDYIMAKYVEHRFARRCTPEPQRLWTAICNRDLLSVLEAFANGQDFG 576

  Fly   173 N---GSAGCLEQELSRQLHASVRTSNLETSL---RFLVQ--------GADPNYYHEDKLSTPLHM 223
            .   |......:||  .||.:|:.:| :.||   .|::|        .||.|        |.||.
Human   577 QPLPGPDAQAPEEL--VLHLAVKVAN-QASLPLVDFIIQNGGHLDAKAADGN--------TALHY 630

  Fly   224 AAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAM---------YDVTDR 279
            ||.:.|...:::||...|.|..::..|.|.|::||..:|....|.|..|.         .|.:..
Human   631 AALYNQPDCLKLLLKGRALVGTVNEAGETALDIARKKHHKECEELLEQAQAGTFAFPLHVDYSWV 695

  Fly   280 IITFLG-----------GKKPDHASGRHMIIPDANG-------------ADISEQLKIARGKLQL 320
            |.|..|           |..|         :|.|:|             ..:..|...|.|:|. 
Human   696 ISTEPGSDSEEDEEEKVGPSP---------VPQASGWQKERARLGLRCLLKLPAQAHWASGRLD- 750

  Fly   321 VPNKMFEELVMDLYDEVDRRECEAIWSTSTLNADHATVPFLPANPFLSATRN--QGRQKLARFNR 383
            :.||.:|.:              |....:|...:....|  |..|..:::|.  ||..:.|..:|
Human   751 ISNKTYETV--------------ASLGAATPQGESEDCP--PPLPVKNSSRTLVQGCARHASGDR 799

  Fly   384 AEFTGLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQSL--PYANNSMLLGSFEQGGHDPNLSDD 446
            :|.:.|.:                  :||    ::.:||  | |::|.|:...|.|         
Human   800 SEVSSLSS------------------EAP----ETPESLGSP-ASSSSLMSPLEPG--------- 832

  Fly   447 EPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQMLSSE 511
                ||       :..||.:::.:...|..|..|                           |:|.
Human   833 ----DP-------SQAPPNSEEGLREPPGTSRPS---------------------------LTSG 859

  Fly   512 NT----QLKSKFSSASNNSVYDEPLRIDLSLSSPD---TEHEPL---SLPEGGTANGESGSSNDS 566
            .|    .|..:|||.|..| |....|      ||:   :..:||   ::|.|.|..  .||...|
Human   860 TTPSEMYLPVRFSSESTRS-YRRGAR------SPEDGPSARQPLPRRNVPVGITEG--DGSRTGS 915

  Fly   567 SNQSTIK 573
            ...|:::
Human   916 LPASSVQ 922

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GitNP_610599.3 ArfGap 48..164 CDD:279720 43/137 (31%)
Ank_2 187..279 CDD:289560 31/111 (28%)
ANK <187..270 CDD:238125 28/93 (30%)
ANK repeat 187..213 CDD:293786 11/36 (31%)
ANK repeat 215..247 CDD:293786 10/31 (32%)
ANK repeat 249..279 CDD:293786 10/38 (26%)
GIT_SHD 314..342 CDD:285690 6/27 (22%)
GIT 374..404 CDD:128828 5/29 (17%)
GIT1_C 609..727 CDD:289013
ASAP3XP_011540057.1 BAR_ASAP3 35..243 CDD:153324
PH_ASAP 296..402 CDD:270071 2/4 (50%)
PH 309..392 CDD:278594
ArfGap 430..545 CDD:279720 43/126 (34%)
ANK repeat 553..586 CDD:293786 6/32 (19%)
ANK repeat 588..621 CDD:293786 10/35 (29%)
ANK <592..676 CDD:238125 28/92 (30%)
Ank_5 610..664 CDD:290568 17/61 (28%)
ANK repeat 623..654 CDD:293786 12/38 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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