DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and git2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_031756118.1	Gene:	git2 / 549671	XenbaseID:	XB-GENE-949238	Length:	802	Species:	Xenopus tropicalis

Alignment Length:	852	Identity:	284/852 - (33%)
Similarity:	399/852 - (46%)	Gaps:	214/852 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWE 95
            :|.|.:.|        |||.||...||.|||:|||:|:|.:|||||||||||||.|:.|:..:|.
Frog     1 MSKRLRSP--------EVCADCSVPDPRWASVNRGVLVCDECCSVHRSLGRHISQVRHLKHTSWP 57

  Fly    96 PSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTF 160
            .::|..|.:|.::||||:|||.|||.::..:|.      ||..|:|.:||.|::||:||:..|.|
Frog    58 TTLLQMVQTLYSNGANSIWEHSLLDPASIMSGK------RKANPQDKVHPNKAEFIRAKYQMLAF 116

  Fly   161 VLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAA 225
            |.:...:|||      ....::||:|||:||||.||||.||.|..||..|:::.:|.|||||:||
Frog   117 VHRLPCRDDD------SVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFNPEKGSTPLHVAA 175

  Fly   226 KFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPD 290
            |.||..|.|:|.:||||....|..|.||::.||...|:.:|:||::..:::|||:..:|.|:|||
Frog   176 KAGQILQAELLAVYGADPGTPDSAGKTPIDYARQGGHHELADRLVEIQHELTDRLAFYLCGRKPD 240

  Fly   291 HASGRHMIIP---DANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIW----ST 348
            |.:|:|.|||   |....|:||..|.|:.|||.:.|.:||||.||:||||||||.:|:|    :.
Frog   241 HKNGQHFIIPQMADRRLLDVSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNH 305

  Fly   349 STLNADHATVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPV 413
            |||..:...|||||.||..|:|||||||||||||..||..|:.|:|.||.|||       ....|
Frog   306 STLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQ-------QGGSV 363

  Fly   414 AGHQSLQSLPYANNSMLLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSA 478
            .|.:.       |..::|.|......:.:..:|:|.||.||||          ::..:.|.....
Frog   364 TGSKE-------NVELVLKSISNQHSNESQDNDQPDYDSVASD----------EETDLETKANKT 411

  Fly   479 NSHNEMET----------------------------LRKQLNDYKSEINQLKNVVQMLSSENTQL 515
            ||...:|.                            |.|..|:...|:..::..:|.|..|||.|
Frog   412 NSEKSLEAELSDGSVTVQEFLELKNALVASESKIQQLMKANNNLSDELRVMQKKLQTLQCENTNL 476

  Fly   516 K-------------SKFSSASNNS--------------------------------VYDE----- 530
            :             |:::..||.|                                .|.|
Frog   477 RRQATTNLYQVPPGSEYTDLSNPSSLKRRPSARGSRPMSMYETGSVQKPYLPMGEITYPEESVNR 541

  Fly   531 ----PLRIDLSL---------SSPDT--------------EHEPLSLPEGGTANGESGSSNDSSN 568
                |..|..|.         |.|.|              ..:..|:||....|....|.:|.::
Frog   542 LQPFPQHIGRSAFVTSSSSLPSFPSTLSWSRDESTRRGSKVEKQNSMPESDYDNTIHDSEHDDTS 606

  Fly   569 QSTIKRPASM--YERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEVKVRSDLVTRRLKELIRA 631
            .|...|..||  .....:|.:|..:.||....          |..|:|..:::.:|:.::||:||
Frog   607 ASRKGRQKSMAWQTEGSIPEIADPDVDISVVL----------PSTEDVIRKTEQITKNIQELLRA 661

  Fly   632 ------------------------------------MQPVPEDQKQSIA---PHGELIRSAVTDL 657
                                                :||:...|..|.:   |..|.|..|||::
Frog   662 AQENKHDRPFERESVRRLRHSLGCFSTLVPWSEKAPLQPLTLQQPDSTSCYIPCSERIHVAVTEM 726

  Fly   658 IALYANLPPNASDPSRETLKLLTRQNILIQHECENLQKAIEADDKQA--IQKNTLEVRDCAFHIA 720
            .||:...|  .||..|.:|:|||.....:|.||   :|.:..:..|.  ||..|.:|..||:.||
Frog   727 AALFPKKP--KSDMVRTSLRLLTSSAYRLQSEC---KKTLPMESSQTTDIQLVTQQVIQCAYDIA 786

  Fly   721 SAIKTLV 727
            .|.|.||
Frog   787 KAAKQLV 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	58/115 (50%)
		Ank_2	187..279	CDD:289560	45/91 (49%)
		ANK	<187..270	CDD:238125	43/82 (52%)
		ANK repeat	187..213	CDD:293786	16/25 (64%)
		ANK repeat	215..247	CDD:293786	18/31 (58%)
		ANK repeat	249..279	CDD:293786	10/29 (34%)
		GIT_SHD	314..342	CDD:285690	18/27 (67%)
		GIT	374..404	CDD:128828	19/29 (66%)
		GIT1_C	609..727	CDD:289013	43/158 (27%)
git2	XP_031756118.1	ArfGap_GIT2	1..111	CDD:350072	58/123 (47%)
		Ank_2	137..229	CDD:403870	45/91 (49%)
		ANK repeat	137..163	CDD:293786	16/25 (64%)
		ANK repeat	165..197	CDD:293786	18/31 (58%)
		GIT_SHD	267..295	CDD:400702	18/27 (67%)
		GIT_SHD	331..359	CDD:400702	19/34 (56%)
		GIT_CC	415..479	CDD:406863	11/63 (17%)
		GIT1_C	638..795	CDD:403431	45/171 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	131	1.000	Domainoid score	I5101
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H41336
Inparanoid	1	1.050	415	1.000	Inparanoid score	I1784
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D175450at33208
OrthoFinder	1	1.000	-	-		FOG0003139
OrthoInspector	1	1.000	-	-		otm48820
Panther	1	1.100	-	-	O	PTHR46097
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2107
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160