DRSC/TRiP Functional Genomics Resources

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Protein Alignment Git and git2

DIOPT Version :10

Sequence 1:NP_610599.3 Gene:Git / 36122 FlyBaseID:FBgn0033539 Length:731 Species:Drosophila melanogaster
Sequence 2:XP_031756118.1 Gene:git2 / 549671 XenbaseID:XB-GENE-949238 Length:802 Species:Xenopus tropicalis


Alignment Length:852 Identity:284/852 - (33%)
Similarity:399/852 - (46%) Gaps:214/852 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 ISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWE 95
            :|.|.:.|        |||.||...||.|||:|||:|:|.:|||||||||||||.|:.|:..:|.
 Frog     1 MSKRLRSP--------EVCADCSVPDPRWASVNRGVLVCDECCSVHRSLGRHISQVRHLKHTSWP 57

  Fly    96 PSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTF 160
            .::|..|.:|.::||||:|||.|||.::..:|.      ||..|:|.:||.|::||:||:..|.|
 Frog    58 TTLLQMVQTLYSNGANSIWEHSLLDPASIMSGK------RKANPQDKVHPNKAEFIRAKYQMLAF 116

  Fly   161 VLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAA 225
            |.:...:|||      ....::||:|||:||||.||||.||.|..||..|:::.:|.|||||:||
 Frog   117 VHRLPCRDDD------SVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFNPEKGSTPLHVAA 175

  Fly   226 KFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPD 290
            |.||..|.|:|.:||||....|..|.||::.||...|:.:|:||::..:::|||:..:|.|:|||
 Frog   176 KAGQILQAELLAVYGADPGTPDSAGKTPIDYARQGGHHELADRLVEIQHELTDRLAFYLCGRKPD 240

  Fly   291 HASGRHMIIP---DANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIW----ST 348
            |.:|:|.|||   |....|:||..|.|:.|||.:.|.:||||.||:||||||||.:|:|    :.
 Frog   241 HKNGQHFIIPQMADRRLLDVSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNH 305

  Fly   349 STLNADHATVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPV 413
            |||..:...|||||.||..|:|||||||||||||..||..|:.|:|.||.|||       ....|
 Frog   306 STLVTETTVVPFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQ-------QGGSV 363

  Fly   414 AGHQSLQSLPYANNSMLLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSA 478
            .|.:.       |..::|.|......:.:..:|:|.||.||||          ::..:.|.....
 Frog   364 TGSKE-------NVELVLKSISNQHSNESQDNDQPDYDSVASD----------EETDLETKANKT 411

  Fly   479 NSHNEMET----------------------------LRKQLNDYKSEINQLKNVVQMLSSENTQL 515
            ||...:|.                            |.|..|:...|:..::..:|.|..|||.|
 Frog   412 NSEKSLEAELSDGSVTVQEFLELKNALVASESKIQQLMKANNNLSDELRVMQKKLQTLQCENTNL 476

  Fly   516 K-------------SKFSSASNNS--------------------------------VYDE----- 530
            :             |:::..||.|                                .|.|     
 Frog   477 RRQATTNLYQVPPGSEYTDLSNPSSLKRRPSARGSRPMSMYETGSVQKPYLPMGEITYPEESVNR 541

  Fly   531 ----PLRIDLSL---------SSPDT--------------EHEPLSLPEGGTANGESGSSNDSSN 568
                |..|..|.         |.|.|              ..:..|:||....|....|.:|.::
 Frog   542 LQPFPQHIGRSAFVTSSSSLPSFPSTLSWSRDESTRRGSKVEKQNSMPESDYDNTIHDSEHDDTS 606

  Fly   569 QSTIKRPASM--YERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEVKVRSDLVTRRLKELIRA 631
            .|...|..||  .....:|.:|..:.||....          |..|:|..:::.:|:.::||:||
 Frog   607 ASRKGRQKSMAWQTEGSIPEIADPDVDISVVL----------PSTEDVIRKTEQITKNIQELLRA 661

  Fly   632 ------------------------------------MQPVPEDQKQSIA---PHGELIRSAVTDL 657
                                                :||:...|..|.:   |..|.|..|||::
 Frog   662 AQENKHDRPFERESVRRLRHSLGCFSTLVPWSEKAPLQPLTLQQPDSTSCYIPCSERIHVAVTEM 726

  Fly   658 IALYANLPPNASDPSRETLKLLTRQNILIQHECENLQKAIEADDKQA--IQKNTLEVRDCAFHIA 720
            .||:...|  .||..|.:|:|||.....:|.||   :|.:..:..|.  ||..|.:|..||:.||
 Frog   727 AALFPKKP--KSDMVRTSLRLLTSSAYRLQSEC---KKTLPMESSQTTDIQLVTQQVIQCAYDIA 786

  Fly   721 SAIKTLV 727
            .|.|.||
 Frog   787 KAAKQLV 793

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GitNP_610599.3 ArfGap_GIT 39..155 CDD:350062 55/115 (48%)
ANKYR <187..>272 CDD:440430 44/84 (52%)
ANK repeat 187..213 CDD:293786 16/25 (64%)
ANK repeat 215..247 CDD:293786 18/31 (58%)
ANK repeat 249..279 CDD:293786 10/29 (34%)
GIT_SHD 314..342 CDD:462506 18/27 (67%)
GIT_SHD 374..402 CDD:462506 18/27 (67%)
GIT1_C 612..731 CDD:463492 44/157 (28%)
git2XP_031756118.1 ArfGap_GIT2 1..111 CDD:350072 58/123 (47%)
ANKYR <123..269 CDD:440430 70/151 (46%)
ANK repeat 137..163 CDD:293786 16/25 (64%)
ANK repeat 165..197 CDD:293786 18/31 (58%)
GIT_SHD 267..295 CDD:462506 18/27 (67%)
GIT_SHD 331..359 CDD:462506 19/34 (56%)
GIT_CC 415..479 CDD:465174 11/63 (17%)
GIT1_C 642..797 CDD:463492 44/157 (28%)

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