DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and AGAP6

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_001071133.2	Gene:	AGAP6 / 414189	HGNCID:	23466	Length:	686	Species:	Homo sapiens

Alignment Length:	236	Identity:	71/236 - (30%)
Similarity:	108/236 - (45%)	Gaps:	31/236 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSV 113
            |.||...:|.|||:|.|:|:|.:|..:|||||.|:|.|:||...:|...:...::|:....|||:
Human   479 CVDCETQNPKWASLNLGVLMCIECSGIHRSLGPHLSRVRSLELDDWPVELRKVMSSIVNDLANSI 543

  Fly   114 WEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSAGC 178
            ||        .|:.|:     .||:.| :....|..:|::|:....| |.|           ..|
Human   544 WE--------GSSQGQ-----TKPSEK-STREEKERWIRSKYEEKLF-LAP-----------LPC 582

  Fly   179 LEQELSRQLHASVRTSNLETSLRFLVQGADPNYYH---EDKLSTPLHMAAKFGQASQIEMLLIYG 240
            .|..|.:||..:....:|:|::..|..|:......   |....|.||:|.:.|.....::|:.||
Human   583 TELSLGQQLLRATADEDLQTAILLLAHGSCEEVNETCGEGDGCTALHLACRKGNVVLAQLLIWYG 647

  Fly   241 ADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRII 281
            .||.|.|.:|.|.|..||..:.......||  .|...|..:
Human   648 VDVMARDAHGNTALTYARQASSQECINVLL--QYGCPDECV 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	39/114 (34%)
		Ank_2	187..279	CDD:289560	26/94 (28%)
		ANK	<187..270	CDD:238125	23/85 (27%)
		ANK repeat	187..213	CDD:293786	5/25 (20%)
		ANK repeat	215..247	CDD:293786	11/31 (35%)
		ANK repeat	249..279	CDD:293786	8/29 (28%)
		GIT_SHD	314..342	CDD:285690
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
AGAP6	NP_001071133.2	PH_AGAP	280..447	CDD:241281
		PH	283..442	CDD:278594
		ArfGap	466..580	CDD:279720	40/126 (32%)
		Ank_2	591..681	CDD:289560	26/91 (29%)
		ANK repeat	591..621	CDD:293786	5/29 (17%)
		ANK	<594..677	CDD:238125	22/82 (27%)
		ANK repeat	623..654	CDD:293786	11/30 (37%)
		ANK repeat	656..681	CDD:293786	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910