DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and ArfGAP3

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_001097664.2	Gene:	ArfGAP3 / 40487	FlyBaseID:	FBgn0037182	Length:	553	Species:	Drosophila melanogaster

Alignment Length:	667	Identity:	134/667 - (20%)
Similarity:	223/667 - (33%)	Gaps:	193/667 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IAPPDLDHSDPATPTISTRSK-MPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSL 79
            :|.|....|.....::.:|.: .|..||      |.||.|..|:|:|:..||.:|.||.:|||:|
  Fly     1 MASPAAGPSKQEIESVFSRLRAQPANKS------CFDCAAKAPTWSSVTYGIFICIDCSAVHRNL 59

  Fly    80 GRHISIVKSLR-QGNWEPSVLNFVN-SLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDA 142
            |.|::.|:|.. ..||....|..:. ..||:.|.....|:.   ||.....|:..| .....:|.
  Fly    60 GVHLTFVRSTNLDTNWTWLQLRQMQLGGNANAAQFFRAHNC---STTDAQVKYNSR-AAQLYRDK 120

  Fly   143 LHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSAGCLEQEL----SRQLHASVRTSNLETSLRFL 203
            |      ..:|:....|...|..|:..|...|:....|::.    ..::..:|:.:|
  Fly   121 L------CAQAQQAMKTHGTKLHLEQTDKSEGNEAAREEDFFAQCDNEVDFNVQNNN-------- 171

  Fly   204 VQGADPNYYHEDKLSTPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAER 268
            |...|||   ...::..:.:..:.|.|..:.:|            |.:.|..:.     ::|..|
  Fly   172 VSKQDPN---PPTVAPVISVETQQGGAPSVNLL------------NSVVPAAVP-----SSIGAR 216

  Fly   269 LLDAMYDVTDRIITFLGGKKPDHASGRHMIIPDANGADI------SEQLKIARGKLQLVPNKMFE 327
                      ::....||.......|........|.|||      :.::|.:.....:|..:..|
  Fly   217 ----------KVQPKKGGLGARKVGGLGATKVKTNFADIEARANAANEMKTSAAAAPVVKPQTAE 271

  Fly   328 ELVMDLYDEVDRRECEAIWSTSTLNADHATVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTD 392
            :            |.|.:.|...            |...||..:.:...||...:.|:
  Fly   272 D------------ELETVASMRL------------AYQELSMQKTREEAKLKTMDPAK------- 305

  Fly   393 VLVDAMRRQNMA-NLRPMD----------------APVAGHQSLQSLPYANNSMLLGSFEQGGHD 440
              ...|.|..|. |||..|                ||.|....|:|..:..:..|.|:...||..
  Fly   306 --AKQMERLGMGFNLRGSDMAHSALGDMETIQQSAAPKAKLSLLESENFFTDFSLYGNSSSGGGG 368

  Fly   441 PNLSD------------DEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLRKQLND 493
            ...|:            |:...|.:.    |..:.|:            ..||:.:.::..:.||
  Fly   369 GGSSEKRESSVGGTSKLDKFELDALG----YETIEPI------------GGSHSNITSMFSRSND 417

  Fly   494 Y---KSEINQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLRIDLSLSSPDTEHEPLSLPEGGT 555
            |   |:.....||      |.::|..:|..::::..:..:..                     |.
  Fly   418 YDKPKTSAPVKKN------SGSSQTHTKGGTSTDPVIAQQKF---------------------GN 455

  Fly   556 ANGESGSSNDSSNQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEVKVRS-- 618
            :.|.......:|.||:....||:       |..:|:..|  ::|.|  .|||.|.|......|
  Fly   456 SKGFGSDQYFASEQSSADVSASL-------NRFQGSRAI--SSSDY--FGDGSPGGTGGNRASSV 509

  Fly   619 -----DLVTRRLKELIR 630
                 ||....:||.:|
  Fly   510 NFSAPDLDVESVKESVR 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	35/117 (30%)
		Ank_2	187..279	CDD:289560	13/91 (14%)
		ANK	<187..270	CDD:238125	13/82 (16%)
		ANK repeat	187..213	CDD:293786	6/25 (24%)
		ANK repeat	215..247	CDD:293786	3/31 (10%)
		ANK repeat	249..279	CDD:293786	4/29 (14%)
		GIT_SHD	314..342	CDD:285690	2/27 (7%)
		GIT	374..404	CDD:128828	5/29 (17%)
		GIT1_C	609..727	CDD:289013	8/29 (28%)
ArfGAP3	NP_001097664.2	ArfGap	17..121	CDD:214518	36/113 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45464120
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.830