DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and Agfg1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_001129068.1	Gene:	Agfg1 / 363266	RGDID:	1560041	Length:	561	Species:	Rattus norvegicus

Alignment Length:	653	Identity:	117/653 - (17%)
Similarity:	190/653 - (29%)	Gaps:	270/653 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 KMPRGKSRL-QTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLG-RHISIVKSLRQGNWEPSV 98
            ||.|..:.| ....|.||....|::.::..|..:|..|....|.|. .|  .|||:....:....
  Rat    15 KMLRDMTGLPHNRKCFDCDQRGPTYVNMTVGSFVCTSCSGSLRGLNPPH--RVKSISMTTFTQQE 77

  Fly    99 LNFVNSLNAHG---ANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTF 160
            :.|   |..||   ...:| ..|.|..:::     :|.:|.|       ....:|::.|:....:
  Rat    78 IEF---LQKHGNEVCKQIW-LGLFDDRSSA-----IPDFRDP-------QKVKEFLQEKYEKKRW 126

  Fly   161 VLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAA 225
            .:.|.              :.::...:|||:..|:..::                 .|||
  Rat   127 YVPPE--------------QAKVVASVHASISGSSASST-----------------SSTP----- 155

  Fly   226 KFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPD 290
               :...::.||  |....||..|..||
  Rat   156 ---EVKPLKSLL--GESAPALHLNKGTP------------------------------------- 178

  Fly   291 HASGRHMIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIWSTSTLNADH 355
                             ::...:.|.:.|....|.| :|:.||..::
  Rat   179 -----------------TQSPVVGRSQGQQQEKKQF-DLLSDLGSDI------------------ 207

  Fly   356 ATVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQ 420
                |....|..:||.|..  ..|.||              :...||.||        |...:..
  Rat   208 ----FAAPAPQSTATANFA--NFAHFN--------------SHAAQNSAN--------AEFANFD 244

  Fly   421 SLPYANNSMLLGSFEQGGHDP-----------NLSDDEPIYD--PVASDDDYAPVPPMAQQAIVH 472
            :...::.|...|.|....|.|           :::.:...:|  |.:|..|:...
  Rat   245 AFGQSSGSSNFGGFPTASHSPFQPQTTGGSAGSVNANFAHFDNFPKSSSADFGSF---------- 299

  Fly   473 TPPRSANSHNEMETLRK--------QLNDYKSEINQLKNV------------------------- 504
               .::.||....|:.|        |..|..:.:..|.|:
  Rat   300 ---STSQSHQTASTVSKVSTNKAGLQTADKYAALANLDNIFSAGQGGDQGSGFGTTGKAPVGSVV 361

  Fly   505 -VQMLSSENT-------QLKSKFSS-ASNNSVYDEPLRIDLSL-------SSPDTEHEPLS---L 550
             |...||.::       :|.|.||| |::|:.|........|:       :||.|  :|.|   .
  Rat   362 SVPSHSSASSDKYAALAELDSVFSSAATSNNAYTSTSNASSSVFGTVPVGASPQT--QPASSGPA 424

  Fly   551 PEGGT--------ANGESGSSNDSSNQSTIKRPASMYERRLVPNVAKGNTDIR-NTTSMYQMAGD 606
            |.|.|        |.|.|.:|:.:..|:.                |:|.|... .|.||...||.
  Rat   425 PFGATPSTNPFVAATGPSAASSTNPFQTN----------------ARGATAATFGTASMSMPAGF 473

  Fly   607 GKP 609
            |.|
  Rat   474 GTP 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	25/119 (21%)
		Ank_2	187..279	CDD:289560	15/91 (16%)
		ANK	<187..270	CDD:238125	15/82 (18%)
		ANK repeat	187..213	CDD:293786	4/25 (16%)
		ANK repeat	215..247	CDD:293786	7/31 (23%)
		ANK repeat	249..279	CDD:293786	3/29 (10%)
		GIT_SHD	314..342	CDD:285690	7/27 (26%)
		GIT	374..404	CDD:128828	5/29 (17%)
		GIT1_C	609..727	CDD:289013	1/1 (100%)
Agfg1	NP_001129068.1	COG5347	8..309	CDD:227651	76/466 (16%)
		ArfGap	14..135	CDD:214518	30/151 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..193		6/75 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..451		12/43 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900