Protein Alignment Git and CG8243

DIOPT Version :10

• Sequence 1: NP_610599.3
• Gene: Git / 36122
• FlyBaseID: FBgn0033539
• Length: 731
• Species: Drosophila melanogaster
• Sequence 2: NP_610424.1
• Gene: CG8243 / 35890
• FlyBaseID: FBgn0033349
• Length: 517
• Species: Drosophila melanogaster
• Alignment Length: 640
• Identity: 128/640 - (20%)
• Similarity: 213/640 - (33%)
• Gaps: 189/640 - (29%)

  Fly    34 RSKMPRGKSR-LQTEV--------CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSL 89
            |:|:.:.|.: |.|::        |.||.|..|.|||.|.|:.||..|..:||:||.|||.|||:
  Fly     9 RTKLIQEKCQTLLTQMLRDEDNKYCVDCDAKGPRWASWNLGMFLCIRCAGIHRNLGVHISRVKSV 73

  Fly    90 RQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAK 154
            ....|.|..:..:..:....|.:|:|..|.||            :|:|....||    .:||:||
  Fly    74 NLDTWTPEQVISLQQMGNSRARAVYEAQLPDG------------FRRPQTDTAL----ENFIRAK 122

  Fly   155 HVNLTFVLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLST 219
            :.:..::.:..:.........|..:::||.||......|....|
  Fly   123 YEHKKYLAREWVPPSPPKVDWAKEIDEELERQKRKKKSTQAQAT--------------------- 166

  Fly   220 PLHMAAKFGQASQIEMLLIYGADVNALDGNGM-TPLELARANNHNTIAERLLDAMYDVTDRIITF 283
             |.:|...|.:....   :.|:..:||....: .||...:.|.
  Fly   167 -LGLAGVAGGSGDKR---LSGSSASALKNTPLPAPLPKPKPNQ---------------------- 205

  Fly   284 LGGKKPDHASGRHMIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIWST 348
            :||..|.......:.....:.|..|:.|.::.....:|.....::|..:.:             |
  Fly   206 VGGCSPKTTQRVQLNSSGVSSAGESDLLGLSSPTKPIVATNASQDLQNESF-------------T 257

  Fly   349 STLNADHATVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPMDAPV 413
            |.|:|:  ::...|..|..|           ..:.|...|...:.|  |...|:..|...:.|
  Fly   258 SFLSAE--SIAGQPDKPIGS-----------NGDAANLMGSKPNSL--AQEEQDFFNQGSLGA-- 305

  Fly   414 AGHQSLQSLPYANNSML-LGSFEQGGHDPNLSDDEPIYDPVASDDDYAP---VPPMAQQAIVH-- 472
            .|::..||...:.:|:| |.......|:|.::        .......||   :....||.|.|
  Fly   306 GGNEKDQSGKMSKDSILALYGSAPATHNPQMN--------FGGFTGMAPGGYMHQQQQQQIPHQF 362

  Fly   473 -TPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLRIDL 536
             |||.|.:.:|.                      .::::.|....:..|||:..|:
  Fly   363 MTPPNSVSMYNS----------------------PVMAAPNAFSNAAISSATAMSM--------- 396

  Fly   537 SLSSPDTEHEPLSLPEGGTANGESGSSNDSSNQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMY 601
                             |.::|.:|:...|:..|              |..|.|.....|.....
  Fly   397 -----------------GGSHGFTGAQFPSTGGS--------------PYAAAGQAAATNLMQTN 430

  Fly   602 QMAGDGKP-FG----EEVKVRSDLVTRRLKEL----IRAMQPVPEDQKQSIAPHG 647
            |....|.| ||    ::.:.:..|..:...:|    :..|||:|........|.|
  Fly   431 QSILSGMPLFGAVPQQQQQHQQQLQQQHHPQLGGLSMNLMQPLPSGLNIGQPPQG 485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap_GIT	39..155	CDD:350062	41/124 (33%)
		ANKYR	<187..>272	CDD:440430	11/85 (13%)
		ANK repeat	187..213	CDD:293786	2/25 (8%)
		ANK repeat	215..247	CDD:293786	5/31 (16%)
		ANK repeat	249..279	CDD:293786	3/30 (10%)
		GIT_SHD	314..342	CDD:462506	2/27 (7%)
		GIT_SHD	374..402	CDD:462506	4/27 (15%)
		GIT1_C	612..731	CDD:463492	8/40 (20%)
CG8243	NP_610424.1	COG5347	20..300	CDD:227651	77/370 (21%)
		ArfGap_SMAP	21..123	CDD:350068	39/117 (33%)