DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and Agap1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_835220.1	Gene:	Agap1 / 347722	MGIID:	2653690	Length:	857	Species:	Mus musculus

Alignment Length:	289	Identity:	82/289 - (28%)
Similarity:	125/289 - (43%)	Gaps:	66/289 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RGKSRL--QTEV--------------CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVK 87
            :.||||  |:|.              |.||...:|:|||:|.|.|:|.:|..:||:||.|:|.|:
Mouse   598 KNKSRLTSQSEAMALQSIRNMRGNSHCVDCDTQNPNWASLNLGALMCIECSGIHRNLGTHLSRVR 662

  Fly    88 SLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIK 152
            ||...:|...::..::|:....||||||    :||...|         ||: .|:....|..:|:
Mouse   663 SLDLDDWPMELIKVMSSIGNELANSVWE----EGSQGRT---------KPS-LDSTREEKERWIR 713

  Fly   153 AKHVNLTFVLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKL 217
            ||:....| |.|           ..|.|..|.:||..:....:|.|.:..|..|:      .|::
Mouse   714 AKYEQKLF-LAP-----------LPCTEFSLGQQLLRATAEEDLRTVILLLAHGS------RDEV 760

  Fly   218 S---------TPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAM 273
            :         |.||:|.:.|.....::|:.||.||.|.|.:|.|.|..||..:.....:.||  .
Mouse   761 NETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVMARDAHGNTALAYARQASSQECIDVLL--Q 823

  Fly   274 YDVTDRIITFLG-------GKKPDHASGR 295
            |...|.....:.       ....:::|||
Mouse   824 YGCPDERFVLMATPNLSRKSNSRNNSSGR 852

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	41/129 (32%)
		Ank_2	187..279	CDD:289560	26/100 (26%)
		ANK	<187..270	CDD:238125	23/91 (25%)
		ANK repeat	187..213	CDD:293786	5/25 (20%)
		ANK repeat	215..247	CDD:293786	12/40 (30%)
		ANK repeat	249..279	CDD:293786	8/29 (28%)
		GIT_SHD	314..342	CDD:285690
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
Agap1	NP_835220.1	Small GTPase-like	66..276
		Centaurin_gamma	72..229	CDD:133303
		RAS	73..235	CDD:214541
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..342
		PH_AGAP	344..592	CDD:241281
		PH	347..>411	CDD:278594
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..431
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	497..547
		ArfGap	611..725	CDD:279720	42/139 (30%)
		Ank_2	736..826	CDD:289560	26/97 (27%)
		ANK	736..>825	CDD:238125	25/96 (26%)
		ANK repeat	768..799	CDD:293786	11/30 (37%)
		ANK 1	768..797		10/28 (36%)
		ANK 2	801..830		9/30 (30%)
		ANK repeat	801..826	CDD:293786	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810