DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and Git2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_017453834.1	Gene:	Git2 / 304546	RGDID:	1359708	Length:	761	Species:	Rattus norvegicus

Alignment Length:	795	Identity:	279/795 - (35%)
Similarity:	404/795 - (50%)	Gaps:	156/795 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RLQT-EVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLN 106
            ||:: :||.||...||||||:|||.|:|.:|||||||||||||.|:.|:...|.|::|..|.:|.
  Rat     4 RLRSNDVCADCSGPDPSWASVNRGTLICDECCSVHRSLGRHISQVRHLKHTPWPPTLLQMVETLY 68

  Fly   107 AHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDD 171
            ::||||:|||.|||.::..:|.      ||..|:|.:||.|::||:||:..|.||.:...:|||
  Rat    69 SNGANSIWEHSLLDPASVMSGR------RKANPQDKVHPNKAEFIRAKYQMLAFVHRLPCRDDD- 126

  Fly   172 GNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAAKFGQASQIEML 236
                 ....::||:|||:||||.||||.||.|..||..|::|.:|.|||||:|:|.||..|.|:|
  Rat   127 -----SVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGSTPLHVASKAGQILQAELL 186

  Fly   237 LIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPDHASGRHMIIPD 301
            .:||||....|.:|.||::.||...|..:||||::..|::|||:..:|.|:||||.:|:|.|||.
  Rat   187 AVYGADPGTHDSSGKTPVDYARQGGHRELAERLVEIQYELTDRLAFYLCGRKPDHKNGQHFIIPQ 251

  Fly   302 AN----GADISEQLKIARGKLQLVPNKMFEELVMDLYDEVDRRECEAIW----STSTLNADHATV 358
            ..    ..|:||..|.|:.|||.:.|.:||||.||:||||||||.:|:|    :.|||..:...|
  Rat   252 MADRRLSLDLSELAKAAKKKLQSLSNHLFEELAMDVYDEVDRRETDAVWLATQNHSTLVTETTVV 316

  Fly   359 PFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANL-RPMDAPVAGHQSLQSL 422
            ||||.||..|:|||||||||||||..||..|:.|:|.||.|||..:.| |..|
  Rat   317 PFLPVNPEYSSTRNQGRQKLARFNAHEFATLVIDILSDAKRRQQGSPLSRSKD------------ 369

  Fly   423 PYANNSMLLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVP-------------------PMAQQ 468
               |..::|.:........:..:|:|.||.||||:| ..|.                   |:..|
  Rat   370 ---NVELILRTVSNQHSTESQDNDQPDYDSVASDED-TDVETRASRTNRQKSLDSDLSDGPVTVQ 430

  Fly   469 AIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLR 533
            ..:........|..:.:.|.|..|:...|:..::..:|.|.|||:.|:.:.::::        .:
  Rat   431 EFMEVKHALVASEAKRQQLMKVNNNLSGELRIMQKKLQTLQSENSSLRRQATASA--------CQ 487

  Fly   534 IDLSLSSPDT-EH------------EPLSLPEGGTAN------GESGSSNDS------------- 566
            :..:....|| .|            .|:|:.|.|:..      ||:....:|
  Rat   488 VQTASDHKDTVSHSSLKRRPSARGSRPMSMYETGSGQKPYLPMGEANHPEESRTRLQPFPTHIGR 552

  Fly   567 -------------------SNQSTIKRPASMYERRLVPNVAKGNTDI-------------RNTTS 599
                               |...:.:|.:.:.::...|.....||..             |..:.
  Rat   553 SALVTSSSSLPSFPSTLSWSRDESTRRASRLEKQNSTPESDYDNTAYDPEPDDTVSGRKGRQRSM 617

  Fly   600 MYQMAGDGK---------------PFGEEVKVRSDLVTRRLKELIRAMQPVPEDQKQSIAPHGEL 649
            ::|  |||.               |..|:|..:::.:|:.::||:||.|   |::..|..|..|.
  Rat   618 LWQ--GDGPLPDTAEPHAVPSPALPSTEDVIRKTEQITKNIQELLRAAQ---ENKHDSYIPCSER 677

  Fly   650 IRSAVTDLIALYANLPPNASDPSRETLKLLTRQNILIQHECENLQKAIEADDK--QAIQKNTLEV 712
            |.:|||::.||:...|  .||..|.:|:|||.....:|.||   :||:..|..  ..:|..|.:|
  Rat   678 IHAAVTEMAALFPKKP--KSDTVRTSLRLLTASAYRLQSEC---RKALPGDSSLPTDVQLVTQQV 737

  Fly   713 RDCAFHIASAIKTLV 727
            ..||:.||.|.|.||
  Rat   738 IQCAYDIAKAAKQLV 752

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	60/115 (52%)
		Ank_2	187..279	CDD:289560	47/91 (52%)
		ANK	<187..270	CDD:238125	44/82 (54%)
		ANK repeat	187..213	CDD:293786	16/25 (64%)
		ANK repeat	215..247	CDD:293786	17/31 (55%)
		ANK repeat	249..279	CDD:293786	12/29 (41%)
		GIT_SHD	314..342	CDD:285690	18/27 (67%)
		GIT	374..404	CDD:128828	19/29 (66%)
		GIT1_C	609..727	CDD:289013	42/119 (35%)
Git2	XP_017453834.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	140	1.000	Domainoid score	I4639
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41336
Inparanoid	1	1.050	450	1.000	Inparanoid score	I1563
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D175450at33208
OrthoFinder	1	1.000	-	-		FOG0003139
OrthoInspector	1	1.000	-	-		otm45726
orthoMCL	1	0.900	-	-		OOG6_104890
Panther	1	1.100	-	-	O	PTHR46097
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2107
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.830