DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Git and Smap2

DIOPT Version :9

Sequence 1:NP_610599.3 Gene:Git / 36122 FlyBaseID:FBgn0033539 Length:731 Species:Drosophila melanogaster
Sequence 2:NP_001094139.1 Gene:Smap2 / 298500 RGDID:1308418 Length:428 Species:Rattus norvegicus


Alignment Length:449 Identity:93/449 - (20%)
Similarity:157/449 - (34%) Gaps:120/449 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSV 113
            |.||.:..|.|||.|.|:.:|..|..:||:||.|||.|||:....|....:..:..:....||.:
  Rat    28 CADCQSKGPRWASWNIGVFICIRCAGIHRNLGVHISRVKSVNLDQWTQEQIQCMQEMGNGKANRL 92

  Fly   114 WEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTF--------VLKPSLQDDD 170
            :|.:|.:            .:|:|    .:.|....||:.|:....:        ||:.. :||.
  Rat    93 YEAYLPE------------TFRRP----QIDPAVEGFIRDKYEKKKYMDRSLDINVLRKE-KDDK 140

  Fly   171 DGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAAKFGQASQIEM 235
            ...||....|:::...:...|:....:...: |.:.:.|      |.:.|:              
  Rat   141 WKRGSEPAPEKKMEPVVFEKVKMPQKKEDAQ-LPRKSSP------KSAAPV-------------- 184

  Fly   236 LLIYGADVNALDGNGMTPLELARANNHNTIA-ERLLDAMYDVTDRIITFLGGKKPDHASGRHM-I 298
                 .|:..||    .|:..:.||:..:.| |:.||.:..|          ..|...|.:.: .
  Rat   185 -----MDLLGLD----APVACSIANSKTSNALEKDLDLLASV----------PSPSSVSRKAVGS 230

  Fly   299 IPDANGA-DISEQLKI---------ARGKLQLVPNKMFEELVMDLY-DEVDRRECEAIWSTSTLN 352
            :|.|..| .:.|.|.:         ..||.||     .::.::.|| .:..:...:|::......
  Rat   231 MPTAGSAGSVPENLNLFPEPGSKSEETGKKQL-----SKDSILSLYGSQTPQMPAQAMFMAPAQM 290

  Fly   353 ADHATVPFLP-ANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDA-----------------MR 399
            |.....|..| ..|..|...:.....:........:|::|.:.:.|                 |.
  Rat   291 AYPTAYPSFPGVTPPNSIMGSMMPPPVGMVAHPGASGMVTPMAMPAGYMGGMQASMAGVPSGMMT 355

  Fly   400 RQN---MANLRPMDAPVAGHQSLQSLPY----------------ANNSMLLGSFEQGGH 439
            .|.   ||::..|...|.|.|..|.|.:                ||..|..|....||:
  Rat   356 TQQAGYMASMAAMPQTVYGVQPAQQLQWNLTQMTQQMAGMNFYGANGMMSYGQSMGGGN 414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GitNP_610599.3 ArfGap 48..164 CDD:279720 34/122 (28%)
Ank_2 187..279 CDD:289560 16/92 (17%)
ANK <187..270 CDD:238125 13/83 (16%)
ANK repeat 187..213 CDD:293786 3/25 (12%)
ANK repeat 215..247 CDD:293786 3/31 (10%)
ANK repeat 249..279 CDD:293786 8/30 (27%)
GIT_SHD 314..342 CDD:285690 6/28 (21%)
GIT 374..404 CDD:128828 5/49 (10%)
GIT1_C 609..727 CDD:289013
Smap2NP_001094139.1 ArfGap_SMAP2 16..122 CDD:350083 32/109 (29%)
PBP1 <102..419 CDD:227507 67/363 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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