DRSC/TRiP Functional Genomics Resources

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Protein Alignment Git and ARFGAP3

DIOPT Version :9

Sequence 1:NP_610599.3 Gene:Git / 36122 FlyBaseID:FBgn0033539 Length:731 Species:Drosophila melanogaster
Sequence 2:NP_055385.3 Gene:ARFGAP3 / 26286 HGNCID:661 Length:516 Species:Homo sapiens


Alignment Length:694 Identity:144/694 - (20%)
Similarity:221/694 - (31%) Gaps:260/694 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 DPATPTISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSL 89
            ||:...|.|..|  |.:|....:||.||||.:||||||..|:.||.||...|||||.|:|.::|.
Human     3 DPSKQDILTIFK--RLRSVPTNKVCFDCGAKNPSWASITYGVFLCIDCSGSHRSLGVHLSFIRST 65

  Fly    90 R-QGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKA 153
            . ..||....|..:.......|:|.:..|  ..|||.|..|:                       
Human    66 ELDSNWSWFQLRCMQVGGNASASSFFHQH--GCSTNDTNAKY----------------------- 105

  Fly   154 KHVNLTFVLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSL---RFLVQGADPNYYHED 215
                               |..|..|.:|..:.| ||..|....|.|   ..:|....|....||
Human   106 -------------------NSRAAQLYREKIKSL-ASQATRKHGTDLWLDSCVVPPLSPPPKEED 150

  Fly   216 KLSTPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRI 280
            ..::  |::.:....:....:    |:.::|...   |:|....||.                  
Human   151 FFAS--HVSPEVSDTAWASAI----AEPSSLTSR---PVETTLENNE------------------ 188

  Fly   281 ITFLGGKKPDHASGRHMIIPDANGADIS-----EQLKIARGKLQLVPNKMFEELVMDLYDEVDRR 340
                ||::..         |...|.::.     |...|.:.|    ||:                
Human   189 ----GGQEQG---------PSVEGLNVPTKATLEVSSIIKKK----PNQ---------------- 220

  Fly   341 ECEAIWSTSTLNADHATVPFLPANPFLSATRNQ-GRQKLAR--FNRAEFTGLLTDVLVDAMRRQN 402
                                  |...|.|.:.. |.||||.  ||..|......|.:.:   :::
Human   221 ----------------------AKKGLGAKKGSLGAQKLANTCFNEIEKQAQAADKMKE---QED 260

  Fly   403 MANLRPMDAPVAGHQSLQS---LPYANNSMLLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVPP 464
            :|.:      |:..:|:.|   |.|.:..:.:...|:    .|:|..:.:      |.|      
Human   261 LAKV------VSKEESIVSSLRLAYKDLEIQMKKDEK----MNISGKKNV------DSD------ 303

  Fly   465 MAQQAIVHTPPRSANSH---NEMETL----------RKQLNDYKSEINQLKNVVQMLSSENTQLK 516
              :..:.....||..||   ::|:|:          ||:.||...:                   
Human   304 --RLGMGFGNCRSVISHSVTSDMQTIEQESPIMAKPRKKYNDDSDD------------------- 347

  Fly   517 SKFSSASNNSVYDEPLRIDLSLSSPDTEHEPLSLPEGGTANGESGSSNDSSNQSTIKRPASM--- 578
            |.|:|:|  |.:|||:.:                      ...|.||.|.|:.|..|:..|.   
Human   348 SYFTSSS--SYFDEPVEL----------------------RSSSFSSWDDSSDSYWKKETSKDTE 388

  Fly   579 -------YERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEV----KVRSDLVTRRLKELIRAM 632
                   |..|...........:.||....:..|:.|....::    :.::|..||...|.:.|.
Human   389 TVLKTTGYSDRPTARRKPDYEPVENTDEAQKKFGNVKAISSDMYFGRQSQADYETRARLERLSAS 453

  Fly   633 QPV------PEDQKQSIAPHGELIRSAVTDLIALYANLPPNASD 670
            ..:      .|.:||   |.|....|:|.          |||.|
Human   454 SSISSADLFEEPRKQ---PAGNYSLSSVL----------PNAPD 484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GitNP_610599.3 ArfGap 48..164 CDD:279720 36/116 (31%)
Ank_2 187..279 CDD:289560 17/94 (18%)
ANK <187..270 CDD:238125 17/85 (20%)
ANK repeat 187..213 CDD:293786 8/28 (29%)
ANK repeat 215..247 CDD:293786 3/31 (10%)
ANK repeat 249..279 CDD:293786 4/29 (14%)
GIT_SHD 314..342 CDD:285690 3/27 (11%)
GIT 374..404 CDD:128828 9/31 (29%)
GIT1_C 609..727 CDD:289013 16/72 (22%)
ARFGAP3NP_055385.3 PLN03114 1..464 CDD:178661 133/659 (20%)
ArfGap 12..116 CDD:279720 42/149 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 170..199 9/62 (15%)
TMF_DNA_bd 246..301 CDD:289127 11/73 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 322..346 6/23 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 390..414 2/23 (9%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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