DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and APPL1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_036228.1	Gene:	APPL1 / 26060	HGNCID:	24035	Length:	709	Species:	Homo sapiens

Alignment Length:	711	Identity:	127/711 - (17%)
Similarity:	224/711 - (31%)	Gaps:	229/711 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 LKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPLHMAAK 226
            ::.:|:|........|..|::          .:.:...:..|.|.....|..:::||...|:.:|
Human     9 IEETLEDSPQTRSLLGVFEED----------ATAISNYMNQLYQAMHRIYDAQNELSAATHLTSK 63

  Fly   227 FGQASQIEMLLIYGAD---VNALDGNGMTPLELARANNHNTIAERLLDAM--------------- 273
            ..:..:.:...:.|.|   .:.|........||:..  |..::.:|.|||
Human    64 LLKEYEKQRFPLGGDDEVMSSTLQQFSKVIDELSSC--HAVLSTQLADAMMFPITQFKERDLKEI 126

  Fly   274 ----------------------------------YDVTDRIITFLGGKKPDHASGRHMIIPDANG 304
                                              |:||:.:.|   .:|..|.:..|.... .|.
Human   127 LTLKEVFQIASNDHDAAINRYSRLSKKRENDKVKYEVTEDVYT---SRKKQHQTMMHYFCA-LNT 187

  Fly   305 ADISEQLKIARGKLQLVP-------------NKMFEELVMDLYDEVD--RRECEAIWST--STL- 351
            ....:::.:....|..:.             |:..||.:.::...|.  |||.::...|  .|:
Human   188 LQYKKKIALLEPLLGYMQAQISFFKMGSENLNEQLEEFLANIGTSVQNVRREMDSDIETMQQTIE 252

  Fly   352 NADHATVPFLPANP----------------FLSATRNQGRQKLARFNRAEFT------------- 387
            :.:.|:.|....:|                :|:|....|........:..||
Human   253 DLEVASDPLYVPDPDPTKFPVNRNLTRKAGYLNARNKTGLVSSTWDRQFYFTQGGNLMSQARGDV 317

  Fly   388 --GLLTDV------LVDAMRRQNMANLRPMDAPVAGHQSLQSLPYANNSMLLGSFEQGGHDP--- 441
              ||..|:      .||...|:....:...|              ...|.:|.:..:..|:.
Human   318 AGGLAMDIDNCSVMAVDCEDRRYCFQITSFD--------------GKKSSILQAESKKDHEEWIC 368

  Fly   442 ---NLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKN 503
               |:|  :.||.....::..|.|...|.:|:..:|    :.....|:||......:....:..:
Human   369 TINNIS--KQIYLSENPEETAARVNQSALEAVTPSP----SFQQRHESLRPAAGQSRPPTARTSS 427

  Fly   504 VVQMLSSENTQLKSKFSSASNNSVY--DEPLRIDLSLSSPDTEHEP---LSLPEGGTAN---GES 560
             ...|.||:|.|    ::.|.:|:.  |.|::.|  :.||..|.:|   .:..:||...   |||
Human   428 -SGSLGSESTNL----AALSLDSLVAPDTPIQFD--IISPVCEDQPGQAKAFGQGGRRTNPFGES 485

  Fly   561 GSSNDSSNQSTI------------------KRPASMYE-------RRLVPNVAK----------- 589
            |.|..|..:.:|                  ..|..:||       .|.:.|:.:
Human   486 GGSTKSETEDSILHQLFIVRFLGSMEVKSDDHPDVVYETMRQILAARAIHNIFRMTESHLLVTCD 550

  Fly   590 ------GNTDIRNTT------SMYQMAGDGKP-FGEEVKVRSDLVTRRLKELIRAMQPVPEDQKQ 641
                  ..|.:...|      .:|....:.|. ||..::..|......|..:....:...|
Human   551 CLKLIDPQTQVTRLTFPLPCVVLYATHQENKRLFGFVLRTSSGRSESNLSSVCYIFESNNE---- 611

  Fly   642 SIAPHGELIRSAV--TDLIALYANLPPNASDPSRETLKLLTRQNILIQHECENLQKAIEAD 700
                 ||.|..:|  ...|||:|.|...||:..:|..::..:|    |.|. |.||.||.|
Human   612 -----GEKICDSVGLAKQIALHAELDRRASEKQKEIERVKEKQ----QKEL-NKQKQIEKD 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	0/1 (0%)
		Ank_2	187..279	CDD:289560	20/143 (14%)
		ANK	<187..270	CDD:238125	13/85 (15%)
		ANK repeat	187..213	CDD:293786	3/25 (12%)
		ANK repeat	215..247	CDD:293786	6/34 (18%)
		ANK repeat	249..279	CDD:293786	10/78 (13%)
		GIT_SHD	314..342	CDD:285690	7/42 (17%)
		GIT	374..404	CDD:128828	9/50 (18%)
		GIT1_C	609..727	CDD:289013	26/95 (27%)
APPL1	NP_036228.1	Required for RAB5A binding	1..428		69/455 (15%)
		BAR_APPL1	20..234	CDD:153315	31/229 (14%)
		BAR-PH_APPL	252..376	CDD:270067	20/139 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	397..434		6/41 (15%)
		F&H	403..414		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	467..491		7/23 (30%)
		PTB_APPL	490..625	CDD:269980	20/143 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	645..709		9/23 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810