DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and ACAP2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_016861535.1	Gene:	ACAP2 / 23527	HGNCID:	16469	Length:	848	Species:	Homo sapiens

Alignment Length:	466	Identity:	119/466 - (25%)
Similarity:	157/466 - (33%)	Gaps:	170/466 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 SSIIEAHRKLFIAPPDLD-HSDPATPTI----STRSKMPRGKSRLQ-------TEVCGDCGAGDP 57
            :||..|:|:.......|| .|.|:|.::    .::.|:.:|:|.||       ...|.|||..||
Human   393 TSIATAYREKGDESEKLDKKSSPSTGSLDSGNESKEKLLKGESALQRVQCIPGNASCCDCGLADP 457

  Fly    58 SWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGS 122
            .|||||.||.||.:|..:|||||.|.|.|:||....|||.:|..:..|.....|.|:|     .:
Human   458 RWASINLGITLCIECSGIHRSLGVHFSKVRSLTLDTWEPELLKLMCELGNDVINRVYE-----AN 517

  Fly   123 TNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSL--------------------- 166
            ....|.|      ||.|  .....|..:|:||:|...||.|.|:
Human   518 VEKMGIK------KPQP--GQRQEKEAYIRAKYVERKFVDKYSISLSPPEQQKKFVSKSSEEKRL 574

  Fly   167 --------------------------------------------------------------QDD 169
                                                                          |..
Human   575 SISKFGPGDQVRASAQSSVIAVNSDEARRESLFCPDELDSLFSYFDTSSKLRSIRSNDSGIQQSS 639

  Fly   170 DDGNG------SAGCL-EQELSR----------------QLHASVRTSNLETSLRFLVQGADPNY 211
            |||..      ||..| |.|..|                ||:.:....||......|..|||.|:
Human   640 DDGRESLPSTVSANSLYEPEGERQDSSMFLDSKHLNPGLQLYRASYEKNLPKMAEALAHGADVNW 704

  Fly   212 YH-EDKLSTPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYD 275
            .: |:..:|||..|...|.....|.||..||:||..|..|..||..|....|
Human   705 ANSEENKATPLIQAVLGGSLVTCEFLLQNGANVNQRDVQGRGPLHHATVLGH------------- 756

  Fly   276 VTDRIITFLGGKKPDHASGRH-----MIIPDANGADISEQLKIARGKLQLVPNKMFEELVMDLYD 335
             |.::..||......||:...     .|..:|..|||...|::||         |.||:
Human   757 -TGQVCLFLKRGANQHATDEEGKDPLSIAVEAANADIVTLLRLAR---------MNEEM------ 805

  Fly   336 EVDRRECEAIW 346
                ||.|.::
Human   806 ----RESEGLY 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	46/115 (40%)
		Ank_2	187..279	CDD:289560	28/92 (30%)
		ANK	<187..270	CDD:238125	27/83 (33%)
		ANK repeat	187..213	CDD:293786	8/25 (32%)
		ANK repeat	215..247	CDD:293786	12/31 (39%)
		ANK repeat	249..279	CDD:293786	6/29 (21%)
		GIT_SHD	314..342	CDD:285690	6/27 (22%)
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
ACAP2	XP_016861535.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810