DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and Adap1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_766311.2	Gene:	Adap1 / 231821	MGIID:	2442201	Length:	374	Species:	Mus musculus

Alignment Length:	362	Identity:	77/362 - (21%)
Similarity:	126/362 - (34%)	Gaps:	105/362 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSV 113
            |.||||.||.|||...|:.:|..|..:||::.: :|.|||:|...|:.:.:.|:.|.....|.:.
Mouse    21 CADCGAPDPDWASYTLGVFICLSCSGIHRNIPQ-VSKVKSVRLDAWDEAQVEFMASHGNEAARAT 84

  Fly   114 WEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDG------ 172
            :|            .|..|.:.:||..|. ...:..:|:||:....||.....:....|
Mouse    85 FE------------SKVPPFYYRPTFSDC-QLLREQWIRAKYERQEFVHVEKQEPYSTGYREGLL 136

  Fly   173 ------NGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKLSTPL------HMAA 225
                  ||      |.|||:...:.|...|:             |::::....|.      |:.|
Mouse   137 WKRGRDNG------QFLSRKFVLTEREGALK-------------YFNKNDAKEPKAVMKIEHLNA 182

  Fly   226 KFGQAS-------QIEML--------LIYGAD-------VNALDG----------NGMTPLELAR 258
            .|..|.       |:..|        .||..|       .|||..          .|.:..:|..
Mouse   183 TFQPAKMGHPHGLQVTYLKDNSTRNIFIYHEDGKEIVDWFNALRAARFHYLQVAFPGASDADLVP 247

  Fly   259 ANNHNTIAERLLD------------AMYDVTDRIITFLGGKKPDHASGRHMIIPDANGADISEQL 311
            ..:.|.:.|..::            ..:.:.||.:.:........|.|...|....:|..:.|.|
Mouse   248 KLSRNYLKEGYMEKTGPKQTEGFRKRWFTMDDRRLMYFKDPLDAFARGEVFIGSKESGYTVLEGL 312

  Fly   312 KIA-------RGKLQLVPNKMFEELVMDLYDEVDRRE 341
            .::       .|...:.|::.|   :.....|.|:||
Mouse   313 PLSTQGHHWPHGITIVTPDRKF---LFTCETESDQRE 346

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	35/114 (31%)
		Ank_2	187..279	CDD:289560	20/141 (14%)
		ANK	<187..270	CDD:238125	20/120 (17%)
		ANK repeat	187..213	CDD:293786	3/25 (12%)
		ANK repeat	215..247	CDD:293786	12/59 (20%)
		ANK repeat	249..279	CDD:293786	4/41 (10%)
		GIT_SHD	314..342	CDD:285690	7/35 (20%)
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
Adap1	NP_766311.2	ArfGap	10..126	CDD:214518	35/118 (30%)
		PH1_ADAP	130..238	CDD:270072	23/126 (18%)
		PH2_ADAP	252..357	CDD:241282	17/98 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810