DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and Adap2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_742145.1	Gene:	Adap2 / 216991	MGIID:	2663075	Length:	381	Species:	Mus musculus

Alignment Length:	232	Identity:	62/232 - (26%)
Similarity:	95/232 - (40%)	Gaps:	40/232 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSV 113
            |.||||.||.|||...||.:|..|..|||:. ..||.|||:|...|:.|::.|:.
Mouse    25 CADCGAADPDWASYKLGIFICLHCSGVHRNF-PDISKVKSVRLDFWDDSMVEFMT---------- 78

  Fly   114 WEHHLLDGSTN--STGGKHVPR-WRKPTPKDALHPTKSDFIKAKHVNLTF------VLKPSLQDD 169
              ||   |:.|  :.....||. :..|...|.| ..|..:|:||:....|      |..|..::.
Mouse    79 --HH---GNLNVKAKFEARVPAFYYVPQANDCL-VLKEQWIRAKYERQEFTAIDKAVSHPGNREG 137

  Fly   170 ---DDGNGSAGCLEQE---LSRQLHASVRTSNLETSLRFLVQGADPN-YYHEDKLSTPLHMAAKF 227
               ..|..:|..|.:.   |||:......|.....:.:.::...|.| .:..:|:..|..:...:
Mouse   138 FLWKRGRDNAQFLRRRFVLLSREGLLKYYTKEEGKAPKAVISIKDLNATFQTEKIGHPHGLQITY 202

  Fly   228 GQASQIEMLLIY---GADV----NALDGNGMTPLELA 257
            .:......|.:|   |.::    |||....:..|:||
Mouse   203 RKEGHTRNLFVYHDSGKEIVDWFNALRAARLQYLKLA 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	41/123 (33%)
		Ank_2	187..279	CDD:289560	14/79 (18%)
		ANK	<187..270	CDD:238125	14/79 (18%)
		ANK repeat	187..213	CDD:293786	3/26 (12%)
		ANK repeat	215..247	CDD:293786	7/38 (18%)
		ANK repeat	249..279	CDD:293786	3/9 (33%)
		GIT_SHD	314..342	CDD:285690
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
Adap2	NP_742145.1	ArfGap	9..123	CDD:279720	39/114 (34%)
		PH1_ADAP	133..241	CDD:270072	20/107 (19%)
		PH	135..231	CDD:278594	17/95 (18%)
		PH2_ADAP	255..362	CDD:241282
		PH	258..361	CDD:278594
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810