Protein Alignment Git and Acap1

DIOPT Version :9

• Sequence 1: NP_610599.3
• Gene: Git / 36122
• FlyBaseID: FBgn0033539
• Length: 731
• Species: Drosophila melanogaster
• Sequence 2: NP_722483.2
• Gene: Acap1 / 216859
• MGIID: 2388270
• Length: 740
• Species: Mus musculus
• Alignment Length: 359
• Identity: 90/359 - (25%)
• Similarity: 138/359 - (38%)
• Gaps: 71/359 - (19%)

  Fly    23 HSDPATPTI----STRSKMPRGKSRLQTEV--------CGDCGAGDPSWASINRGILLCADCCSV 75
            |:..:..|:    :.|.:...|..::..:|        |.||....|.|||||.|:.||..|..:
Mouse   382 HAPGSAATLACGGAARGRESGGVGQVAAQVQSVDGNAQCCDCREPAPEWASINLGVTLCIQCSGI 446

  Fly    76 HRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPK 140
            |||||.|.|.|:||...:|||.::..:..|.....|.::|..:           .....:||.|
Mouse   447 HRSLGVHFSKVRSLTLDSWEPELVKLMCELGNVIINQIYEARV-----------EAMAVKKPGP- 499

  Fly   141 DALHPTKSDFIKAKHVNLTFVLK-PSLQDDDDGNG-----------------------SAGCLEQ 181
            ......|..:|.||:|...|:.| |.::....|.|                       .:.|...
Mouse   500 SCSRQEKEAWIHAKYVEKKFLTKLPEIRGRRGGRGPPRGHPPVPPKPPIRPHSGIVRSKSECPSD 564

  Fly   182 ELSRQLH-------ASVRTSNLETSLRFLVQGADPNYYHEDK-LSTPLHMAAKFGQASQIEMLLI 238
            ::. .||       |:....:|.|....|..|||.|:.:..: .:|||..|.........|.||.
Mouse   565 DMG-SLHPGALLFQAAGHPPSLPTMADALAHGADVNWVNVGQGNATPLIRATAANSLLACEFLLQ 628

  Fly   239 YGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPDHASGRH--MIIPD 301
            .||:||..|..|..||..|....|..:|...|....|        ||.:..:   ||.  .|..:
Mouse   629 NGANVNQADSAGRGPLHHATILGHTGLACLFLKRGAD--------LGARDTE---GRDPLTIAME 682

  Fly   302 ANGADISEQLKIAR-GKLQLVPNKMFEELVMDLY 334
            ...|||...|::|: .:.:....:..:|..:|::
Mouse   683 TTNADIVTLLRLAKMREAEAAQGQAGDETYLDIF 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	40/124 (32%)
		Ank_2	187..279	CDD:289560	30/99 (30%)
		ANK	<187..270	CDD:238125	28/90 (31%)
		ANK repeat	187..213	CDD:293786	10/32 (31%)
		ANK repeat	215..247	CDD:293786	11/32 (34%)
		ANK repeat	249..279	CDD:293786	8/29 (28%)
		GIT_SHD	314..342	CDD:285690	3/22 (14%)
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
Acap1	NP_722483.2	Required for formation of endosomal tubules when overexpressed with PIP5K1C. /evidence=ECO:0000250|UniProtKB:Q15027	1..382		90/359 (25%)
		BAR_ACAP1	18..217	CDD:153323
		PH	266..360	CDD:278594
		PH_ACAP	268..364	CDD:270070
		Required for interaction with GULP1. /evidence=ECO:0000250|UniProtKB:Q15027	405..740		86/336 (26%)
		ArfGap	406..519	CDD:279720	38/124 (31%)
		Prevents interaction with ITGB1 when S-554 is not phosphorylated. /evidence=ECO:0000250	525..566		3/40 (8%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	525..562		2/36 (6%)
		Ank_2	575..670	CDD:289560	30/102 (29%)
		ANK repeat	575..602	CDD:293786	8/26 (31%)
		ANK	<592..692	CDD:238125	33/110 (30%)
		ANK repeat	606..637	CDD:293786	11/30 (37%)
		ANK repeat	639..670	CDD:293786	10/38 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810