DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and Agap2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_006513621.1	Gene:	Agap2 / 216439	MGIID:	3580016	Length:	1342	Species:	Mus musculus

Alignment Length:	192	Identity:	61/192 - (31%)
Similarity:	94/192 - (48%)	Gaps:	29/192 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANSV 113
            |.||||.:|:|||:|.|.|:|.:|..:||:||.|:|.|:||...:|...:...:.::....||.|
Mouse   940 CVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRV 1004

  Fly   114 WEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSAGC 178
            ||        :.|.|:     .||| :|:....:..:|:||:..|.| |.|           .|.
Mouse  1005 WE--------SDTRGR-----AKPT-RDSSREERESWIRAKYEQLLF-LAP-----------LGT 1043

  Fly   179 LEQELSRQLHASVRTSNLETSLRFLV---QGADPNYYHEDKLSTPLHMAAKFGQASQIEMLL 237
            .|:.|.|||.|:|...::...|..|.   .|.......:.:|.:|||:||:.......::||
Mouse  1044 TEEPLGRQLWAAVEAQDVAAVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLL 1105

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	41/114 (36%)
		Ank_2	187..279	CDD:289560	14/54 (26%)
		ANK	<187..270	CDD:238125	14/54 (26%)
		ANK repeat	187..213	CDD:293786	6/28 (21%)
		ANK repeat	215..247	CDD:293786	8/23 (35%)
		ANK repeat	249..279	CDD:293786
		GIT_SHD	314..342	CDD:285690
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
Agap2	XP_006513621.1	PHA03247	<52..320	CDD:223021
		Centaurin_gamma	401..560	CDD:133303
		PH_AGAP	668..908	CDD:241281
		ArfGap_AGAP	926..1033	CDD:350065	38/106 (36%)
		SelP_N	<1136..1188	CDD:368014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810