DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and Appl2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_660255.1	Gene:	Appl2 / 216190	MGIID:	2384914	Length:	662	Species:	Mus musculus

Alignment Length:	169	Identity:	42/169 - (24%)
Similarity:	63/169 - (37%)	Gaps:	59/169 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   373 QGRQKLARFNRAEFTGLLTDV---LVDAMRR----QNMANLRPMDAPVAGHQ-SLQSLPYANNSM 429
            |.|..|:.|.  |..|.|||.   |:.||:|    ||       :..:|..| |.|.|.|...:.
Mouse    18 QARSLLSVFE--EDAGTLTDYTNQLLQAMQRVYGAQN-------EMCLATQQLSRQLLAYEKQNF 73

  Fly   430 LLGSFEQGGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRSANSHNEMET-LRKQLND 493
            .||.          .|:|.|                   :.:|...:..:..|.:.| |.|||.|
Mouse    74 ALGK----------GDEEVI-------------------STLHYFSKVMDELNGLHTELAKQLAD 109

  Fly   494 YK------------SEINQLKNVVQMLSSENTQLKSKFS 520
            ..            :|::.||::..:.|||:....:|:|
Mouse   110 TMVLPVIQFREKDLTEVSTLKDLFGLASSEHDLSMAKYS 148

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720
		Ank_2	187..279	CDD:289560
		ANK	<187..270	CDD:238125
		ANK repeat	187..213	CDD:293786
		ANK repeat	215..247	CDD:293786
		ANK repeat	249..279	CDD:293786
		GIT_SHD	314..342	CDD:285690
		GIT	374..404	CDD:128828	14/36 (39%)
		GIT1_C	609..727	CDD:289013
Appl2	NP_660255.1	BAR_APPL2	20..234	CDD:153316	41/167 (25%)
		BAR-PH_APPL	252..376	CDD:270067
		PH	278..378	CDD:278594
		PH domain	278..376
		PTB_APPL	480..613	CDD:269980
		PTB domain	491..607
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	642..662
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900