DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and Arap2

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_848494.2	Gene:	Arap2 / 212285	MGIID:	2684416	Length:	1703	Species:	Mus musculus

Alignment Length:	814	Identity:	159/814 - (19%)
Similarity:	277/814 - (34%)	Gaps:	228/814 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQ--GNWEPSVLNFVNSLNAHGAN 111
            |.||.|.||.|||||..:::|..|...|||||...|.|:||:.  ..|...::.....:....||
Mouse   698 CADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRAN 762

  Fly   112 SVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSA 176
            ..|..:|.........        .|..|      :.:||..|:....|  :.:|        .|
Mouse   763 DFWAGNLQKDEELQVD--------SPVEK------RKNFITQKYKEGKF--RKTL--------LA 803

  Fly   177 GCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKL-STPLHMAAKFGQASQIEMLLIY- 239
            ...::||::.|.|:|...::..::..|..|||......|.: |||..:|.|.||:.|:|.|  |
Mouse   804 SLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFL--YH 866

  Fly   240 ---------------GADVNALDGNGMTPL--ELARANNHNTIAERLLDAMYDVTDRIITFLGGK 287
                           |:..:|...:.:...  :.|.|.:..:..::||:   |...:.....||.
Mouse   867 NKFSDFPQYDAHFEGGSSQDAAQSSFLCDFLYQTAAAASRVSSEKKLLE---DTNKKWCVLEGGF 928

  Fly   288 KPDHASGRHMIIPDANGA-DISEQLKIARGK----LQLVPNKMFE-------------------- 327
            ...:.:.|   ....||. :|||.:.:|..|    |...|..:||
Mouse   929 LSYYENDR---CTTPNGTINISEVICLAVHKEDFYLNTGPIFVFEIYLPSERVFLFGAETSQIQR 990

  Fly   328 -------------------ELVMDLYDEVDRRECEAI--WSTSTLNADHATVPFLPANPFLSATR 371
                               |...||..::..::|.|:  |.......|.:::.|.    ..:...
Mouse   991 KWTETIAKRFVPFVAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLCFC----LQTQEA 1051

  Fly   372 NQGRQKLARFNRAEFT-----GLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQSLPYANNSMLL 431
            .:.|..|.|......:     |...|||:...:.:.:.        :.||..|....:..
Mouse  1052 QEERMNLRRLQELTISTMVQNGEKVDVLLLVEKGRTLY--------IHGHTKLDFTVWHT----- 1103

  Fly   432 GSFEQ-GGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRS-------------ANSHN 482
             :.|: .|.|.|...|:.:    ..:|    ||.:....|.......             .:...
Mouse  1104 -AIEKAAGTDGNALQDQQL----CKND----VPIIVNSCIAFVTQYGLGCKYIYQKDGDPLHISE 1159

  Fly   483 EMETLRKQLNDYKSEI--NQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLRIDLSLSSPDTEH 545
            .:|:.:|.....|...  :||::|..:|.|        |.|..::::..:.| ....:|:.||:.
Mouse  1160 LLESFKKDARSVKLRAGKHQLEDVTGVLKS--------FLSDIDDALLTKEL-YPYWVSALDTQD 1215

  Fly   546 EP----------LSLPEGGTANGESGSSNDSSNQSTIKRPASMYERRL-------VPNVAKGNTD 593
            |.          .|||              ..|::|:   |::.|...       :.::...|..
Mouse  1216 EKERTSKYRAFIRSLP--------------GVNRATL---AALIEHLYRVQKCSEINHMNAHNLA 1263

  Fly   594 IRNTTSMYQMAGDGKPFGEEVKVRSDLVTRRLKELIRAMQPVPEDQKQSIAPHGELIR------- 651
            :..::.::|..|.   ..|||.|..||:...::     :..|.|||.:.:......|.
Mouse  1264 MVFSSCLFQTKGQ---TSEEVNVIEDLINNYVE-----IFEVKEDQVKQMDIENSFITKWKDTQV 1320

  Fly   652 SAVTDLI--ALYANLPPNAS-----DPSRE----TLKLLTRQNILIQH----------ECENLQK 695
            |...||:  .......|:.|     .|..|    |..:|..:||:...          |.|.|::
Mouse  1321 SQAGDLLIEVFVERKEPDCSIIIRISPVMEAEELTNDILAIKNIIPMKGDIWATFEVIENEELER 1385

  Fly   696 AIEADD---KQAIQKNTLEVRDCAFHIASAIKTL 726
            .:...:   :|.:|.::|.....|:.:.....|:
Mouse  1386 PLHYTENVLEQVLQWSSLAEPGSAYLVVKRFLTI 1419

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	33/116 (28%)
		Ank_2	187..279	CDD:289560	26/110 (24%)
		ANK	<187..270	CDD:238125	23/101 (23%)
		ANK repeat	187..213	CDD:293786	7/25 (28%)
		ANK repeat	215..247	CDD:293786	14/48 (29%)
		ANK repeat	249..279	CDD:293786	5/31 (16%)
		GIT_SHD	314..342	CDD:285690	9/70 (13%)
		GIT	374..404	CDD:128828	7/34 (21%)
		GIT1_C	609..727	CDD:289013	30/149 (20%)
Arap2	NP_848494.2	SAM_Arap1,2,3	6..68	CDD:188889
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	84..132
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..232
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..319
		PH1_ARAP	482..573	CDD:270073
		PH2_ARAP	583..673	CDD:270074
		ArfGap_ARAP2	678..798	CDD:350081	33/115 (29%)
		PH3_ARAP	890..1000	CDD:270076	19/115 (17%)
		PH-like	1013..1108	CDD:388408	18/112 (16%)
		RhoGAP_ARAP	1112..1291	CDD:239850	38/215 (18%)
		RA_ARAP2	1323..1420	CDD:340747	18/97 (19%)
		PH-like	1426..1537	CDD:388408
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1633..1670
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1684..1703
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810