DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Git and F07F6.4

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	NP_495029.2	Gene:	F07F6.4 / 173927	WormBaseID:	WBGene00017217	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	655	Identity:	129/655 - (19%)
Similarity:	208/655 - (31%)	Gaps:	226/655 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 SDPATPT-ISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVK 87
            ||...|: :..::.|.:.::....::|.||||.:|:|.::..|:.||.||.:|||:||.|
Worm     2 SDENGPSKVDLQTAMRKMRALPPNKLCFDCGARNPTWCTVTYGVFLCIDCSAVHRNLGVH----- 61

  Fly    88 SLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIK 152
                       |.||.|.|            ||  ||.|       |.:              ::
Worm    62 -----------LTFVRSTN------------LD--TNWT-------WLQ--------------LR 80

  Fly   153 AKHVNLTFVLKPSLQDDDDGNGSA-------GCLEQELSRQLHASVRTSNLETSLRFLVQGADPN 210
            |..:.              |||:|       ||...| ::|.:.|.........|..|.|.|...
Worm    81 AMQLG--------------GNGNANQFFKAHGCNTTE-AQQKYKSRAAQMYRDKLSTLCQEAQRK 130

  Fly   211 YYHEDKLSTPLH-----------MAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNT 264
            :..:..:.|..|           .|..||..|         |...:|..:.......:..:.|
Worm   131 FGTQLIIDTVTHAEEKPAEEEDFFAQDFGHTS---------ASATSLSSDAYIADHKSEDSTH-- 184

  Fly   265 IAERLLDAMYDVTDRIITFLGGKKPDHASGRHMIIPDANGADISEQLK--IARGKLQLVPNKMFE 327
                                 |...||... .:.:|  ..|.:|..||  |.:..|....|.:..
Worm   185 ---------------------GPSVDHLDS-SVAVP--TSAPVSVILKKPIKKATLGAKKNALGA 225

  Fly   328 ELVMDLYDEVDRRECEAIWSTSTLNADHATVPFLPANPFLSATRNQGRQK---LARFNRAEFTGL 389
            :.|...:||:::|..|         .:..|...:.||.....|...|::|   .|...:......
Worm   226 QKVRINFDEIEQRAAE---------KERQTAAEVAANKLAYQTELDGKKKSDDAAALQKLSAKFA 281

  Fly   390 LTDVLVDAMRRQNMANL---------------------RPMDAPVAGHQSLQ----------SLP 423
            :.|  :||.|:|..|.:                     |...:...|.:|::          |.|
Worm   282 MQD--IDAQRKQMEAKVAKDPTKAASVDRLGMGGVGRSRAAHSVAGGIRSIKQDDVLTFKKPSQP 344

  Fly   424 YANNSMLLGSFEQGGHDPNLSDDEPIYDPVAS--------DDDYAPVPPMAQQAIVHTPPRSANS 480
            ..::...:...:.|....|..||....|..:|        ||.:........|...:|...|::|
Worm   345 KEDDDWEVIDDKYGKKSTNNEDDFFSKDYTSSSSKKTTKEDDFFDSFETQPVQKSRYTASSSSSS 409

  Fly   481 HNEMETLRKQLNDYKSEINQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLRIDLSLSSPDTEH 545
            .:...|.|  |....|.|:            :..|:.||.:|       :.:..|:...:|:.:.
Worm   410 TSRAPTTR--LTAGASPIS------------DVDLQKKFGNA-------KAISSDMYFGTPEMDC 453

  Fly   546 E---PLSLPEGGTANGE-----SGSSNDSSNQ----------------------STIKRPASMYE 580
            |   .|:..||.|:.|.     :||....|:|                      ||:....|.|.
Worm   454 ETRSALTKCEGQTSFGSEDLWGNGSQQRQSSQVPDMSDLKDSFRAGASKVAEKWSTLSSSFSTYM 518

  Fly   581 RRLVP 585
            .|..|
Worm   519 SRAPP 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	30/115 (26%)
		Ank_2	187..279	CDD:289560	14/102 (14%)
		ANK	<187..270	CDD:238125	14/93 (15%)
		ANK repeat	187..213	CDD:293786	5/25 (20%)
		ANK repeat	215..247	CDD:293786	7/42 (17%)
		ANK repeat	249..279	CDD:293786	1/29 (3%)
		GIT_SHD	314..342	CDD:285690	6/27 (22%)
		GIT	374..404	CDD:128828	8/32 (25%)
		GIT1_C	609..727	CDD:289013
F07F6.4	NP_495029.2	ArfGap	16..129	CDD:214518	44/178 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900