DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Git and AGAP1

DIOPT Version :9

Sequence 1:	NP_610599.3	Gene:	Git / 36122	FlyBaseID:	FBgn0033539	Length:	731	Species:	Drosophila melanogaster
Sequence 2:	XP_006712302.2	Gene:	AGAP1 / 116987	HGNCID:	16922	Length:	1151	Species:	Homo sapiens

Alignment Length:	289	Identity:	80/289 - (27%)
Similarity:	125/289 - (43%)	Gaps:	66/289 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 RGKSRL--QTEV--------------CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVK 87
            :.||||  |:|.              |.||...:|:|||:|.|.|:|.:|..:||:||.|:|.|:
Human   892 KNKSRLTSQSEAMALQSIRNMRGNSHCVDCETQNPNWASLNLGALMCIECSGIHRNLGTHLSRVR 956

  Fly    88 SLRQGNWEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIK 152
            ||...:|...::..::|:....||||||        .|:.|:     .||: .|:....|..:|:
Human   957 SLDLDDWPVELIKVMSSIGNELANSVWE--------ESSQGR-----TKPS-VDSTREEKERWIR 1007

  Fly   153 AKHVNLTFVLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKL 217
            ||:....| |.|           ..|.|..|.:.|..:....:|.|::..|..|:      .|::
Human  1008 AKYEQKLF-LAP-----------LPCTELSLGQHLLRATADEDLRTAILLLAHGS------RDEV 1054

  Fly   218 S---------TPLHMAAKFGQASQIEMLLIYGADVNALDGNGMTPLELARANNHNTIAERLLDAM 273
            :         |.||:|.:.|.....::|:.||.||.|.|.:|.|.|..||..:.....:.||  .
Human  1055 NETCGEGDGRTALHLACRKGNVVLAQLLIWYGVDVTARDAHGNTALAYARQASSQECIDVLL--Q 1117

  Fly   274 YDVTDRIITFLG-------GKKPDHASGR 295
            |...|.....:.       ....:::|||
Human  1118 YGCPDERFVLMATPNLSRRNNNRNNSSGR 1146

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Git	NP_610599.3	ArfGap	48..164	CDD:279720	40/129 (31%)
		Ank_2	187..279	CDD:289560	26/100 (26%)
		ANK	<187..270	CDD:238125	23/91 (25%)
		ANK repeat	187..213	CDD:293786	5/25 (20%)
		ANK repeat	215..247	CDD:293786	12/40 (30%)
		ANK repeat	249..279	CDD:293786	8/29 (28%)
		GIT_SHD	314..342	CDD:285690
		GIT	374..404	CDD:128828
		GIT1_C	609..727	CDD:289013
AGAP1	XP_006712302.2	Centaurin_gamma	337..498	CDD:133303
		RAS	338..504	CDD:214541
		PH_AGAP	613..886	CDD:241281
		PH	616..>680	CDD:278594
		PH	<830..881	CDD:278594
		ArfGap	905..1019	CDD:279720	41/139 (29%)
		Ank_2	1030..1120	CDD:289560	26/97 (27%)
		ANK	1030..>1119	CDD:238125	25/96 (26%)
		ANK repeat	1062..1093	CDD:293786	11/30 (37%)
		ANK repeat	1095..1120	CDD:293786	8/26 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5347
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810