DRSC/TRiP Functional Genomics Resources

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Protein Alignment Git and AGAP2

DIOPT Version :9

Sequence 1:NP_610599.3 Gene:Git / 36122 FlyBaseID:FBgn0033539 Length:731 Species:Drosophila melanogaster
Sequence 2:NP_001116244.1 Gene:AGAP2 / 116986 HGNCID:16921 Length:1192 Species:Homo sapiens


Alignment Length:226 Identity:74/226 - (32%)
Similarity:112/226 - (49%) Gaps:29/226 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly    48 VCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGNWEPSVLNFVNSLNAHGANS 112
            :|.||||.:|:|||:|.|.|:|.:|..:||:||.|:|.|:||...:|...:...:.::....||.
Human   945 ICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANR 1009

  Fly   113 VWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSAG 177
            |||        :.|.|:     .||: :|:....:..:|:||:..|.|:...|..          
Human  1010 VWE--------SDTRGR-----AKPS-RDSSREERESWIRAKYEQLLFLAPLSTS---------- 1050

  Fly   178 CLEQELSRQLHASVRTSNLETSLRFLV---QGADPNYYHEDKLSTPLHMAAKFGQASQIEMLLIY 239
              |:.|.|||.|:|:..::.|.|..|.   .|.......:.:|.:|||:||:.......::||.|
Human  1051 --EEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWY 1113

  Fly   240 GADVNALDGNGMTPLELARANNHNTIAERLL 270
            ||||.|.|..|.|.|..||.......|:.||
Human  1114 GADVAARDAQGRTALFYARQAGSQLCADILL 1144

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GitNP_610599.3 ArfGap 48..164 CDD:279720 39/115 (34%)
Ank_2 187..279 CDD:289560 30/87 (34%)
ANK <187..270 CDD:238125 28/85 (33%)
ANK repeat 187..213 CDD:293786 7/28 (25%)
ANK repeat 215..247 CDD:293786 14/31 (45%)
ANK repeat 249..279 CDD:293786 8/22 (36%)
GIT_SHD 314..342 CDD:285690
GIT 374..404 CDD:128828
GIT1_C 609..727 CDD:289013
AGAP2NP_001116244.1 Interaction with EPB41L1. /evidence=ECO:0000250 1..23
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 24..377
Interactions with HOMER1 and NF2. /evidence=ECO:0000250 180..225
Interaction with PLCG1. /evidence=ECO:0000250 267..390
G domain 405..572
small_GTPase 405..572 CDD:197466
Centaurin_gamma 407..566 CDD:133303
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 582..619
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 634..673
PH_AGAP 674..914 CDD:241281
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 769..854
PH <845..909 CDD:278594
ArfGap 933..1047 CDD:279720 39/115 (34%)
Ank_2 1058..1148 CDD:289560 30/87 (34%)
ANK 1058..>1147 CDD:238125 30/87 (34%)
ANK repeat 1058..1088 CDD:293786 7/29 (24%)
ANK repeat 1090..1121 CDD:293786 14/30 (47%)
ANK 1 1090..1119 13/28 (46%)
ANK 2 1123..1152 8/22 (36%)
ANK repeat 1123..1148 CDD:293786 8/22 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1153..1192
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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