DRSC/TRiP Functional Genomics Resources

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Protein Alignment Git and ARAP1

DIOPT Version :9

Sequence 1:NP_610599.3 Gene:Git / 36122 FlyBaseID:FBgn0033539 Length:731 Species:Drosophila melanogaster
Sequence 2:NP_001035207.1 Gene:ARAP1 / 116985 HGNCID:16925 Length:1450 Species:Homo sapiens


Alignment Length:817 Identity:171/817 - (20%)
Similarity:286/817 - (35%) Gaps:231/817 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    31 ISTRSKMPRGKSRLQTEVCGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQGN-- 93
            :||.....|..:......|.||||..|.|||||..:::|..|...||.||..:|.|:||:...  
Human   532 LSTSEVAERIWAAAPNRFCADCGAPQPDWASINLCVVICKRCAGEHRGLGAGVSKVRSLKMDRKV 596

  Fly    94 WEPSVLNFVNSLNAHGANSVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNL 158
            |..:::.....|.....|..|             ..:||      |.:||.|:.|...:..|:..
Human   597 WTETLIELFLQLGNGAGNRFW-------------AANVP------PSEALQPSSSPSTRRCHLEA 642

  Fly   159 TF------VLKPSLQDDDDGNGSAGCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHED-K 216
            .:      ...|..     ||      ::||.:.|.|:|.|::|..:...|..||..|.:..| :
Human   643 KYREGKYRRYHPLF-----GN------QEELDKALCAAVTTTDLAETQALLGCGAGINCFSGDPE 696

  Fly   217 LSTPLHMAAKFGQASQIEMLL-IYGADVNALDGNGMTPLELARANNHNTI--------------- 265
            ..|||.:|.:.||..|:|.|. ....:|..||  .|.|||     .|.::               
Human   697 APTPLALAEQAGQTLQMEFLRNNRTTEVPRLD--SMKPLE-----KHYSVVLPTVSHSGFLYKTA 754

  Fly   266 -AERLLD-------------------AMYDVTDRIITFLGGKKPDHASGRHMIIPDANGADISEQ 310
             |.:||.                   ..|...:|.:|..|..:........:..||.:|.:.:.:
Human   755 SAGKLLQDRRAREEFSRRWCVLGDGVLSYFENERAVTPNGEIRASEIVCLAVPPPDTHGFEHTFE 819

  Fly   311 LKIARGKLQLVPNKMFEE-----------LVMDLYDEVDRRECEAI-----------------W- 346
            :.....:|.|...:..|:           .|..|.:::..|:.|.:                 | 
Human   820 VYTEGERLYLFGLESAEQAHEWVKCIAKAFVPPLAEDLLARDFERLGRLPYKAGLSLQRAQEGWF 884

  Fly   347 --STSTLNADHATVPFLPANPFLSATRNQGRQKLARFNRAEFTGLLTDVLVDAMRRQNMANLRPM 409
              |.|.|.|      ..|..|.....:.:..|:|:....:|     ..|||...||:.:.     
Human   885 SLSGSELRA------VFPEGPCEEPLQLRKLQELSIQGDSE-----NQVLVLVERRRTLY----- 933

  Fly   410 DAPVAGHQSLQSLPYANNSMLLGSFEQGG-------HDPNLSD-DEP--IYDPVASDDDYAPVPP 464
               :.|.:.|..:.:      ||:.::..       .:..|.| |.|  :|..|    ||.....
Human   934 ---IQGERRLDFMGW------LGAIQKAAASMGDTLSEQQLGDSDIPVIVYRCV----DYITQCG 985

  Fly   465 MAQQAIVHTPPRSANSHNEMETLRKQLNDYKSEINQLKNVVQMLSSENTQLKSKFSSASNNSVYD 529
            :..:.|.....:::.:...:|:||:   |.:|.  .||...|.:...::.|| :|.....:.::.
Human   986 LTSEGIYRKCGQTSKTQRLLESLRQ---DARSV--HLKEGEQHVDDVSSALK-RFLRDLPDGLFT 1044

  Fly   530 EPLRID-LSLSSPDTEHEPLS--------LPEGGTANGESGSSN-------DSSNQSTIKRPASM 578
            ...|:. |..|..:.|.|.:|        ||....|..::..|:       ..:||..:...|.:
Human  1045 RAQRLTWLEASEIEDEEEKVSRYRELLVRLPPVNRATVKALISHLYCVQCFSDTNQMNVHNLAIV 1109

  Fly   579 YERRLVPNVAKGNTDIRNTTSMYQMAGDGKPFGEEVKVRSDLVT-------------RRLKELIR 630
            :          |.|       ::|..|.....|   :|..||:.             |:.:|.|.
Human  1110 F----------GPT-------LFQTDGQDYKAG---RVVEDLINHYVVVFSVDEEELRKQREEIT 1154

  Fly   631 AMQPVPEDQKQSIAPH-GELI-------RSAVTDLIALYANLPPNASDPSRE-TLKLLTRQNILI 686
            |:..:......|...| |:.|       :.|.|:   .:..:|  ||..:.| ||::|.|:|:.|
Human  1155 AIVKMRVAGTASGTQHAGDFICTVYLEEKKAETE---QHIKVP--ASMTAEELTLEILDRRNVGI 1214

  Fly   687 QHECENLQKAIEADDKQAIQKNTLEVRDCAFHIASAI 723
            :          |.|.....:.|..|..:...|.|..:
Human  1215 R----------EKDYWTCFEVNEREEAERPLHFAEKV 1241

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GitNP_610599.3 ArfGap 48..164 CDD:279720 33/123 (27%)
Ank_2 187..279 CDD:289560 31/128 (24%)
ANK <187..270 CDD:238125 28/100 (28%)
ANK repeat 187..213 CDD:293786 9/25 (36%)
ANK repeat 215..247 CDD:293786 11/33 (33%)
ANK repeat 249..279 CDD:293786 9/64 (14%)
GIT_SHD 314..342 CDD:285690 6/38 (16%)
GIT 374..404 CDD:128828 8/29 (28%)
GIT1_C 609..727 CDD:289013 30/137 (22%)
ARAP1NP_001035207.1 SAM_Arap1,2,3 6..68 CDD:188889
SAM 10..64 CDD:197735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 89..144
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 173..302
PH 328..419 CDD:278594
PH1_ARAP 329..421 CDD:270073
PH2_ARAP 436..525 CDD:270074
ArfGap 535..651 CDD:279720 34/134 (25%)
PH3_ARAP 743..849 CDD:270076 13/105 (12%)
PH 744..848 CDD:278594 13/103 (13%)
PH4_ARAP 862..952 CDD:270077 20/114 (18%)
RhoGAP_ARAP 956..1135 CDD:239850 41/208 (20%)
RA 1172..1261 CDD:279168 20/85 (24%)
PH5_ARAP 1263..1402 CDD:270079
PH 1299..1391 CDD:278594
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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