DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Git and ARAP2

DIOPT Version :9

Sequence 1:NP_610599.3 Gene:Git / 36122 FlyBaseID:FBgn0033539 Length:731 Species:Drosophila melanogaster
Sequence 2:NP_056045.2 Gene:ARAP2 / 116984 HGNCID:16924 Length:1704 Species:Homo sapiens


Alignment Length:687 Identity:136/687 - (19%)
Similarity:239/687 - (34%) Gaps:179/687 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 CGDCGAGDPSWASINRGILLCADCCSVHRSLGRHISIVKSLRQ--GNWEPSVLNFVNSLNAHGAN 111
            |.||.|.||.|||||..:::|..|...|||||...|.|:||:.  ..|...::.....:....||
Human   700 CADCKAPDPDWASINLCVVICKKCAGQHRSLGPKDSKVRSLKMDASIWSNELIELFIVIGNKRAN 764

  Fly   112 SVWEHHLLDGSTNSTGGKHVPRWRKPTPKDALHPTKSDFIKAKHVNLTFVLKPSLQDDDDGNGSA 176
            ..|.     |:.......|:.   .|..|      :.:||..|:....|  :.:|        .|
Human   765 DFWA-----GNLQKDEELHMD---SPVEK------RKNFITQKYKEGKF--RKTL--------LA 805

  Fly   177 GCLEQELSRQLHASVRTSNLETSLRFLVQGADPNYYHEDKL-STPLHMAAKFGQASQIEMLL--- 237
            ...::||::.|.|:|...::..::..|..|||......|.: |||..:|.|.||:.|:|.|.   
Human   806 SLTKEELNKALCAAVVKPDVLETMALLFSGADVMCATGDPVHSTPYLLAKKAGQSLQMEFLYHNK 870

  Fly   238 --------IYGADVNALDGNGMTPLELARANNHNTIAERLLDAMYDVTDRIITFLGGKKPDHASG 294
                    |:...|            |::.::.:|.   |.|.:|............||....:.
Human   871 FSDFPQHDIHSEGV------------LSQESSQSTF---LCDFLYQAPSAASKLSSEKKLLEETN 920

  Fly   295 RHMIIPDA--------------NGA-DISEQLKIARGK----LQLVPNKMFE------------- 327
            :...:.:.              ||. :|:|.:.:|..|    |...|..:||             
Human   921 KKWCVLEGGFLSYYENDKSTTPNGTININEVICLAIHKEDFYLNTGPIFIFEIYLPSERVFLFGA 985

  Fly   328 --------------------------ELVMDLYDEVDRRECEAI--WSTSTLNADHATVPFLPAN 364
                                      |...||..::..::|.|:  |.......|.:::.|.   
Human   986 ETSQAQRKWTEAIAKHFVPLFAENLTEADYDLIGQLFYKDCHALDQWRKGWFAMDKSSLHFC--- 1047

  Fly   365 PFLSATRNQG-RQKLARFNRAEFT-----GLLTDVLVDAMRRQNMANLRPMDAPVAGHQSLQSLP 423
              |.....|| |..|.|......:     |...|||:...:.:.:.        :.||..|....
Human  1048 --LQMQEVQGDRMHLRRLQELTISTMVQNGEKLDVLLLVEKGRTLY--------IHGHTKLDFTV 1102

  Fly   424 YANNSMLLGSFEQ-GGHDPNLSDDEPIYDPVASDDDYAPVPPMAQQAIVHTPPRS---------- 477
            :..      :.|: .|.|.|...|:.:     |.:|   ||.:....|.......          
Human  1103 WHT------AIEKAAGTDGNALQDQQL-----SKND---VPIIVNSCIAFVTQYGLGCKYIYQKN 1153

  Fly   478 ---ANSHNEMETLRKQLNDYKSEI--NQLKNVVQMLSSENTQLKSKFSSASNNSVYDEPLRIDLS 537
               .:....:|:.:|....:|...  :||::|..:|.|        |.|..::::..:.| ....
Human  1154 GDPLHISELLESFKKDARSFKLRAGKHQLEDVTAVLKS--------FLSDIDDALLTKEL-YPYW 1209

  Fly   538 LSSPDTEHEPLSLPEGGTANGESGSSNDSSNQSTIKRPASMYERRLVPNVAKGNTDIRNTTSMYQ 602
            :|:.||:.:...:.:.|.........|.::..:.|:....:.:...:.::...|..:..::.::|
Human  1210 ISALDTQDDKERIKKYGAFIRSLPGVNRATLAAIIEHLYRVQKCSEINHMNAHNLALVFSSCLFQ 1274

  Fly   603 MAGDGKPFGEEVKVRSDLVTRRLKELIRAMQPVPEDQ 639
            ..|.   ..|||.|..||:...::     :..|.|||
Human  1275 TKGQ---TSEEVNVIEDLINNYVE-----IFEVKEDQ 1303

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
GitNP_610599.3 ArfGap 48..164 CDD:279720 34/116 (29%)
Ank_2 187..279 CDD:289560 25/103 (24%)
ANK <187..270 CDD:238125 22/94 (23%)
ANK repeat 187..213 CDD:293786 7/25 (28%)
ANK repeat 215..247 CDD:293786 13/43 (30%)
ANK repeat 249..279 CDD:293786 5/29 (17%)
GIT_SHD 314..342 CDD:285690 9/70 (13%)
GIT 374..404 CDD:128828 8/35 (23%)
GIT1_C 609..727 CDD:289013 10/31 (32%)
ARAP2NP_056045.2 SAM_Arap1,2,3 6..68 CDD:188889
SAM 13..65 CDD:197735
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 126..161
PH1_ARAP 484..576 CDD:270073
PH 484..574 CDD:278594
PH 588..679 CDD:278594
PH2_ARAP 588..675 CDD:270074
ArfGap 686..801 CDD:279720 34/116 (29%)
PH3_ARAP 892..1002 CDD:270076 16/112 (14%)
PH 921..998 CDD:278594 10/76 (13%)
PH4_ARAP 1015..1110 CDD:270077 21/113 (19%)
RhoGAP_ARAP 1114..1293 CDD:239850 34/198 (17%)
UBQ 1330..1417 CDD:294102
PH5_ARAP 1423..1543 CDD:270079
PH 1436..1537 CDD:278594
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1636..1675
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5347
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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